Pediatric Panic Disorder Differential Diagnoses

  • Author: Jeffrey S Forrest, MD; Chief Editor: Caroly Pataki, MD   more...
 
Updated: Dec 16, 2011
 
 

Diagnostic Considerations

Currently, no consistent physiologic findings have been identified as diagnostic for panic disorder. However, adults with panic disorder have been found to differ from adults without the disorder. For example, panic disorder sometimes is associated with signs of compensated respiratory alkalosis. An increased frequency of panic attack response in reaction to sodium lactate infusion or carbon dioxide inhalation has been reported in research settings.[1]

Panic attacks and agoraphobia can occur with several anxiety disorders.

Although panic disorder is more frequent in older adolescents and adults, it does occur in children. It is an important disorder to consider because unrecognized and untreated panic disorder can have a devastating impact on a child's life and can interfere with normal development, schoolwork, and relationships.

Because literature describes the risk of suicide in patients with comorbid depression and because risks are associated with unwarranted diagnostic procedures, consideration of this diagnosis is important when a child presents with the symptoms described earlier.

In the event that further nonpsychiatric medical evaluation is warranted, early mental health professional consultation is important to obtain assistance in excluding this diagnosis.

The initial assessment of symptoms of mental health problems such as panic disorder is commonly performed by a primary care physician. In recent times, mental health screening has been called for as a routine component of pediatric health care.[5]

The family context of a patient presenting with panic disorder symptoms should also be understood, as it may influence the presentation of the patient.[6]

Conditions to consider in the differential diagnosis of panic disorder include the following:

  • Anxiety disorder caused by a general medical condition
  • Substance-induced anxiety disorder
  • Delusional disorder
  • Psychotic disorder

Panic disorder may be and frequently is comorbid with other anxiety disorders, including the listed differential diagnoses.[7] Despite the broad differential diagnosis, panic disorder may be identified in children when a systematic assessment is used.[7]

Go to Pediatric Generalized Anxiety Disorder and Pediatric Obsessive-Compulsive Disorder for complete information on these topics.

Differential Diagnoses

Proceed to Workup
 
 
Contributor Information and Disclosures
Author

Jeffrey S Forrest, MD 

Disclosure: Nothing to disclose.

Coauthor(s)

Nirupama Natarajan, MD  Fellow in Child and Adolescent Psychiatry, Carilion Clinic, Virginia Tech Carilion School of Medicine

Nirupama Natarajan, MD is a member of the following medical societies: Academy of Psychosomatic Medicine, American Academy of Child and Adolescent Psychiatry, American Academy of Psychiatry and the Law, American Association for Emergency Psychiatry, American Association of Physicians of Indian Origin, American Medical Association, American Psychiatric Association, American Society for Adolescent Psychiatry, American Society of Clinical Psychopharmacology, Association for Academic Psychiatry, Association of Clinical Research Professionals, and Medical Society of Virginia

Disclosure: Nothing to disclose.

Chief Editor

Caroly Pataki, MD  Professor of Clinical Psychiatry and Behavioral Sciences, Department of Psychiatry, Division Chair, Child and Adolescent Psychiatry, Keck School of Medicine of the University of Southern California

Caroly Pataki, MD is a member of the following medical societies: American Academy of Child and Adolescent Psychiatry, New York Academy of Sciences, and Physicians for Social Responsibility

Disclosure: Nothing to disclose.

Additional Contributors

Chet Johnson, MD Medical Director, Child Development Unit, Department of Pediatrics, Professor, University of Kansas Medical Center

Chet Johnson, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Lene Holm Larsen, PhD Instructor, Department of Child and Adolescent Psychiatry, Children's Memorial Hospital of Chicago

Disclosure: Nothing to disclose.

Carrie Sylvester, MD, MPH Senior Child and Adolescent Psychiatrist, Sound Mental Health

Carrie Sylvester, MD, MPH is a member of the following medical societies: American Academy of Child and Adolescent Psychiatry

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

References
  1. Meuret AE, Rosenfield D, Hofmann SG, Suvak MK, Roth WT. Changes in respiration mediate changes in fear of bodily sensations in panic disorder. J Psychiatr Res. Mar 2009;43(6):634-41. [Medline].

  2. Hayward C, Killen JD, Kraemer HC. Predictors of panic attacks in adolescents. J Am Acad Child Adolesc Psychiatry. Feb 2000;39(2):207-14. [Medline].

  3. Ost L, Treffers PD. Onset, course, and outcome for anxiety disorders in children. In: Silverman W, Treffers PD, eds. Anxiety Disorders in Children & Adolescent. 2001:293-312.

  4. Last CG, Perrin S, Hersen M, Kazdin AE. A prospective study of childhood anxiety disorders. J Am Acad Child Adolesc Psychiatry. Nov 1996;35(11):1502-10. [Medline].

  5. Queen AH, Ehrenreich-May J, Hershorin ER. Preliminary Validation of a Screening Tool for Adolescent Panic Disorder in Pediatric Primary Care Clinics. Child Psychiatry Hum Dev. Sep 22 2011;[Medline].

  6. Agency for Healthcare Research and Quality. Guideline summary: Practice parameter for the psychiatric assessment and management of physically ill children and adolescents. Accessed December 7, 2011. National Guideline Clearinghouse (NGC). [Full Text].

  7. Doerfler LA, Connor DF, Volungis AM, Toscano PF Jr. Panic disorder in clinically referred children and adolescents. Child Psychiatry Hum Dev. Jun 2007;38(1):57-71. [Medline].

  8. Agency for Healthcare Research and Quality (AHRQ). Guideline summary: Practice guideline for the treatment of patients with panic disorder. Accessed December 7, 2011. National Guideline Clearinghouse (NGC). [Full Text].

  9. March JS, Parker JD, Sullivan K, et al. The Multidimensional Anxiety Scale for Children (MASC): factor structure, reliability, and validity. J Am Acad Child Adolesc Psychiatry. Apr 1997;36(4):554-65. [Medline].

  10. Birmaher B, Brent DA, Chiappetta L, et al. Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. J Am Acad Child Adolesc Psychiatry. Oct 1999;38(10):1230-6. [Medline].

  11. Barrett PM, Rapee RM, Dadds MM, Ryan SM. Family enhancement of cognitive style in anxious and aggressive children. J Abnorm Child Psychol. Apr 1996;24(2):187-203. [Medline].

  12. Kendall PC. Treating anxiety disorders in children: results of a randomized clinical trial. J Consult Clin Psychol. Feb 1994;62(1):100-10. [Medline].

  13. Kendall PC, Sugarman A. Attrition in the treatment of childhood anxiety disorders. J Consult Clin Psychol. Oct 1997;65(5):883-8. [Medline].

  14. Chavira DA, Stein MB, Golinelli D, Sherbourne CD, Craske MG, Sullivan G, et al. Predictors of clinical improvement in a randomized effectiveness trial for primary care patients with panic disorder. J Nerv Ment Dis. Oct 2009;197(10):715-21. [Medline].

  15. Teachman BA, Marker CD, Smith-Janik SB. Automatic associations and panic disorder: trajectories of change over the course of treatment. J Consult Clin Psychol. Dec 2008;76(6):988-1002. [Medline].

  16. Masi G, Toni C, Mucci M, Millepiedi S, Mata B, Perugi G. Paroxetine in child and adolescent outpatients with panic disorder. J Child Adolesc Psychopharmacol. Summer 2001;11(2):151-7. [Medline].

  17. Lepola UM, Wade AG, Leinonen EV, et al. A controlled, prospective, 1-year trial of citalopram in the treatment of panic disorder. J Clin Psychiatry. Oct 1998;59(10):528-34. [Medline].

  18. Simon GE, Savarino J, Operskalski B, Wang PS. Suicide risk during antidepressant treatment. Am J Psychiatry. Jan 2006;163(1):41-7. [Medline]. [Full Text].

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