eMedicine Specialties > Pediatrics: General Medicine > Endocrinology

Glucocorticoid Therapy and Cushing Syndrome: Multimedia

Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London), Professor and Chair, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, Greece
Coauthor(s): Antony Lafferty, MB ChB, FRACP, Senior Lecturer of Pediatric Endocrinology, Monash University Department of Pediatrics, National Institutes of Health, Bethesda, MD, and Princess Margaret Hospital for Children, Perth, Western Australia
Contributor Information and Disclosures

Updated: Mar 11, 2009

Multimedia

Pathophysiology of Cushing syndrome.Media file 1: Pathophysiology of Cushing syndrome.
Pathophysiology of Cushing syndrome.

Pathophysiology of Cushing syndrome.

Glucocorticoid equivalencies. Printer-friendly ve...Media file 2: Glucocorticoid equivalencies. Printer-friendly version of Table 1 (PDF).
Glucocorticoid equivalencies. Printer-friendly ve...

Glucocorticoid equivalencies. Printer-friendly version of Table 1 (PDF).

Effects of glucocorticoids during long-term thera...Media file 3: Effects of glucocorticoids during long-term therapy. Printer-friendly version of Table 2 (PDF).
Effects of glucocorticoids during long-term thera...

Effects of glucocorticoids during long-term therapy. Printer-friendly version of Table 2 (PDF).

Genetic causes of Cushing syndrome. Printer-frien...Media file 4: Genetic causes of Cushing syndrome. Printer-friendly version of Table 3 (PDF).
Genetic causes of Cushing syndrome. Printer-frien...

Genetic causes of Cushing syndrome. Printer-friendly version of Table 3 (PDF).

Glucocorticoids and other drugs.Media file 5: Glucocorticoids and other drugs.
Glucocorticoids and other drugs.

Glucocorticoids and other drugs.

Diagnosis of Cushing syndrome.Media file 6: Diagnosis of Cushing syndrome.
Diagnosis of Cushing syndrome.

Diagnosis of Cushing syndrome.

Etiology of Cushing syndrome.Media file 7: Etiology of Cushing syndrome.
Etiology of Cushing syndrome.

Etiology of Cushing syndrome.

Physical findings in Cushing syndrome.Media file 8: Physical findings in Cushing syndrome.
Physical findings in Cushing syndrome.

Physical findings in Cushing syndrome.

More on Glucocorticoid Therapy and Cushing Syndrome

Overview: Glucocorticoid Therapy and Cushing Syndrome
Differential Diagnoses & Workup: Glucocorticoid Therapy and Cushing Syndrome
Treatment & Medication: Glucocorticoid Therapy and Cushing Syndrome
Follow-up: Glucocorticoid Therapy and Cushing Syndrome
Multimedia: Glucocorticoid Therapy and Cushing Syndrome
References

References

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  21. Magiakou MA, Chrousos GP. Corticosteroid Therapy, Nonendocrine Disease, and Corticosteroid Withdrawal. In: Bardin CW, ed. Current Therapy in Endocrinology and Metabolism. 6th ed. St. Louis, Mo: Mosby; 1997:138-142.

  22. Magiakou MA, Mastorakos G, Chrousos GP. Cushing Syndrome: Differential Diagnosis and Treatment. In: Wierman ME, ed. Diseases of the Pituitary: Diagnosis and Treatment. Totowa, NJ: Humana Press; 1997:179-202.

  23. Magiakou MA, Smyrnaki P, Chrousos GP. Hypertension in Cushing's syndrome. Best Pract Res Clin Endocrinol Metab. Sep 2006;20(3):467-82. [Medline].

  24. Merke DP, Giedd JN, Keil MF, et al. Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome. J Clin Endocrinol Metab. May 2005;90(5):2531-6. [Medline][Full Text].

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  27. Orth DN, Kovacs WJ. The Adrenal Cortex. In: Wilson JD, Foster DW, Kronenberg H, Larsen PR, eds. Williams Textbook of Endocrinology. 9th ed. Philadelphia, Pa: WB Saunders; 1998:517-665.

  28. Papanicolaou DA, Chrousos GP. Cushing's Syndrome. In: Rakel RE, ed. Rakel's Current Therapy. Philadelphia, Pa: WB Saunders; 1999:631-637.

  29. Ruiz-Maldonado R, Zapata G, Lourdes T, Robles C. Cushing's syndrome after topical application of corticosteroids. Am J Dis Child. Mar 1982;136(3):274-5. [Medline].

  30. Shepherd FA, Hoffert B, Evans WK, Emery G, Trachtenberg J. Ketoconazole. Use in the treatment of ectopic adrenocorticotropic hormone production and Cushing's syndrome in small-cell lung cancer. Arch Intern Med. May 1985;145(5):863-4. [Medline].

  31. Tsai M-J, Clark JH, Schrader WT. Mechanisms of action of Hormones that Act as Transcription-Regulatory factors. In: Williams Textbook of Endocrinology. Philadelphia, Pa: WB Saunders; 1998:55-95.

  32. Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK. Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states. JAMA. May 5 1993;269(17):2232-8. [Medline].

Further Reading

Keywords

glucocorticoid therapy, Cushing syndrome, Cushing's syndrome, CS, Cushing disease, Cushing's disease, CD, hypercortisolism, treatment, diagnosis, adrenalectomy, Nelson syndrome, multiple endocrine neoplasia type 1, MEN1, pheochromocytoma, primary pigmented nodular adrenal disease, PPNAD, McCune-Albright syndrome, adrenal cortical carcinoma, growth failure, hyperinsulinemia, insulin resistance, diabetes mellitus, peptic ulcer, pancreatitis, lymphopenia, eosinopenia, monocytopenia, sleep disturbances, insomnia, hypertension, hypokalemia, metabolic alkalosis, obesity, pubertal delay, hirsutism, hyperandrogenemia, acne, poor wound healing, cataracts, hypercalciuria, juvenile rheumatoid arthritis, JRA, anxiety, precocious puberty, lipoma, acanthosis, skin tags, tuberculosis, hypothyroidism, pseudohypoparathyroidism, Laurence-Moon syndrome, Bardet-Biedl syndrome, Smith-Magenis syndrome, Alstrom syndrome, cherubism, Prader-Willi syndrome

Contributor Information and Disclosures

Author

George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London), Professor and Chair, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, Greece
George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London) is a member of the following medical societies: American Academy of Pediatrics, American College of Endocrinology, American College of Physicians, American Pediatric Society, American Society for Clinical Investigation, Association of American Physicians, Endocrine Society, Lawson-Wilkins Pediatric Endocrine Society, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Coauthor(s)

Antony Lafferty, MB ChB, FRACP, Senior Lecturer of Pediatric Endocrinology, Monash University Department of Pediatrics, National Institutes of Health, Bethesda, MD, and Princess Margaret Hospital for Children, Perth, Western Australia
Antony Lafferty, MB ChB, FRACP is a member of the following medical societies: Endocrine Society
Disclosure: Nothing to disclose.

Medical Editor

Thomas A Wilson, MD, Professor of Clinical Pediatrics, Department of Pediatrics; Director of Pediatric Endocrinology, Division of Pediatric Endocrinology, Department of Pediatrics, State University of New York at Stony Brook
Thomas A Wilson, MD is a member of the following medical societies: Endocrine Society, Lawson-Wilkins Pediatric Endocrine Society, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

Lynne Lipton Levitsky, MD, Chief, Pediatric Endocrine Unit, Massachusetts General Hospital; Associate Professor, Department of Pediatrics, Harvard University Medical School
Lynne Lipton Levitsky, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Diabetes Association, American Pediatric Society, Endocrine Society, Lawson-Wilkins Pediatric Endocrine Society, and Society for Pediatric Research
Disclosure: Pfizer Grant/research funds P.I.; Tercica Grant/research funds PI, also occasional consultant

CME Editor

Merrily P M Poth, MD, Professor, Department of Pediatrics and Neuroscience, Uniformed Services University of the Health Sciences
Merrily P M Poth, MD is a member of the following medical societies: American Academy of Pediatrics, Endocrine Society, and Lawson-Wilkins Pediatric Endocrine Society
Disclosure: Nothing to disclose.

Chief Editor

Stephen Kemp, MD, PhD, Professor, Department of Pediatrics, Section of Pediatric Endocrinology, University of Arkansas and Arkansas Children's Hospital
Stephen Kemp, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, American Pediatric Society, Endocrine Society, Phi Beta Kappa, Southern Medical Association, and Southern Society for Pediatric Research
Disclosure: Genentech, Inc. Honoraria Speaking and teaching; Pfizer, Inc. Honoraria Consulting

 
 
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