Hypogonadism Differential Diagnoses

  • Author: Stephen Kemp, MD, PhD; Chief Editor: Bruce Buehler, MD   more...
 
Updated: Apr 21, 2010
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Stephen Kemp, MD, PhD  Professor, Department of Pediatrics, Section of Pediatric Endocrinology, University of Arkansas and Arkansas Children's Hospital

Stephen Kemp, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, American Pediatric Society, Endocrine Society, Phi Beta Kappa, Southern Medical Association, and Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Specialty Editor Board

Phyllis W Speiser, MD  Chief, Division of Pediatric Endocrinology, The Children's Hospital, North Shore LIJ Health System; Professor of Pediatrics, New York University School of Medicine

Phyllis W Speiser, MD is a member of the following medical societies: American Association of Clinical Endocrinologists, Endocrine Society, Lawson-Wilkins Pediatric Endocrine Society, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Pharmacy Editor, eMedicine

Disclosure: Nothing to disclose.

Barry B Bercu, MD  Professor, Departments of Pediatrics, Molecular Pharmacology and Physiology, University of South Florida College of Medicine, All Children's Hospital

Barry B Bercu, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, American Federation for Clinical Research, American Medical Association, American Pediatric Society, Association of Clinical Scientists, Endocrine Society, Florida Medical Association, Lawson-Wilkins Pediatric Endocrine Society, Pituitary Society, Society for Pediatric Research, Society for the Study of Reproduction, and Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Merrily P M Poth, MD  Professor, Department of Pediatrics and Neuroscience, Uniformed Services University of the Health Sciences

Merrily P M Poth, MD is a member of the following medical societies: American Academy of Pediatrics, Endocrine Society, and Lawson-Wilkins Pediatric Endocrine Society

Disclosure: Nothing to disclose.

Chief Editor

Bruce Buehler, MD  Professor, Department of Pediatrics and Genetics, Director RSA, University of Nebraska Medical Center

Bruce Buehler, MD is a member of the following medical societies: American Academy for Cerebral Palsy and Developmental Medicine, American Academy of Pediatrics, American Association on Mental Retardation, American College of Medical Genetics, American College of Physician Executives, American Medical Association, and Nebraska Medical Association

Disclosure: Nothing to disclose.

References

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  3. Silveira LG, Noel SD, Silveira-Neto AP, et al. Mutations of the KISS1 Gene in Disorders of Puberty. J Clin Endocrinol Metab. Mar 17 2010;[Medline].

  4. [Guideline] Tekgul S, Riedmiller H, Gerharz E, et al. Micropenis. Guidelines on paediatric urology. Mar 2009;[Full Text].

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  6. Achermann JC, Gu WX, Kotlar TJ, et al. Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. J Clin Endocrinol Metab. Dec 1999;84(12):4497-500. [Medline].

  7. Bhagavath B, Podolsky RH, Ozata M, et al. Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism. Fertil Steril. Mar 2006;85(3):706-13. [Medline].

  8. Bouvattier C, Tauber M, Jouret B, et al. Gonadotropin treatment of hypogonadotropic hypogonadal adolescents. J Pediatr Endocrinol Metab. Apr 1999;12 Suppl 1:339-44. [Medline].

  9. Carey PO, Howards SS, Vance ML. Transdermal testosterone treatment of hypogonadal men. J Urol. Jul 1988;140(1):76-9. [Medline].

  10. Kaneko N, Kawagoe S, Hiroi M. Turner's syndrome--review of the literature with reference to a successful pregnancy outcome. Gynecol Obstet Invest. 1990;29(2):81-7. [Medline].

  11. Lamberts SW, de Jong FH, Birkenhager JC. Evaluation of a therapeutic regimen in Cushing's disease. The predictability of the result of unilateral adrenalectomy followed by external pituitary irradiation. Acta Endocrinol (Copenh). Sep 1977;86(1):146-55. [Medline].

  12. Lee PA. Disorders of puberty. In: Lifshitz F, ed. Pediatric Endocrinology. 3rd ed. Marcel Dekker; 1996:175-95.

  13. Mazer N, Bell D, Wu J, et al. Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men. J Sex Med. Mar 2005;2(2):213-26. [Medline].

  14. Muscatelli F, Strom TM, Walker AP, et al. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature. Dec 15 1994;372(6507):672-6. [Medline].

  15. Navot D, Laufer N, Kopolovic J, et al. Artificially induced endometrial cycles and establishment of pregnancies in the absence of ovaries. N Engl J Med. Mar 27 1986;314(13):806-11. [Medline].

  16. Pozo J, Argente J. Ascertainment and treatment of delayed puberty. Horm Res. 2003;60 Suppl 3:35-48. [Medline].

  17. Rogol AD. Pubertal androgen therapy in boys. Pediatr Endocrinol Rev. Mar 2005;2(3):383-90. [Medline].

  18. Rosenbloom AL, Almonte AS, Brown MR, et al. Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene. J Clin Endocrinol Metab. Jan 1999;84(1):50-7. [Medline].

  19. Saenger P. Clinical review 48: The current status of diagnosis and therapeutic intervention in Turner's syndrome. J Clin Endocrinol Metab. Aug 1993;77(2):297-301. [Medline].

  20. Seminara SB, Oliveira LM, Beranova M, et al. Genetics of hypogonadotropic hypogonadism. J Endocrinol Invest. Oct 2000;23(9):560-5. [Medline].

  21. Snyder PJ, Lawrence DA. Treatment of male hypogonadism with testosterone enanthate. J Clin Endocrinol Metab. Dec 1980;51(6):1335-9. [Medline].

  22. Thomas PQ, Dattani MT, Brickman JM, et al. Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia. Hum Mol Genet. Jan 1 2001;10(1):39-45. [Medline].

 
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Types of idiopathic hypogonadotropic hypogonadism.
 
 
 
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