eMedicine Specialties > Pediatrics: General Medicine > Endocrinology

Hypomagnesemia: Multimedia

Author: James E Springate, MD, Associate Professor of Pediatrics, State University of New York at Buffalo; Attending Physician, Department of Pediatrics, Division of Pediatric Nephrology, Women & Children's Hospital of Buffalo
Coauthor(s): Gunjeet K Kala, MD, Clinical Instructor, Division of Pediatric Nephrology, University of Buffalo State University of New York School of Medicine and Biomedical Sciences, Women and Children's Hospital of Buffalo
Contributor Information and Disclosures

Updated: Sep 18, 2009

Multimedia

(A) Magnesium reabsorption in the thick ascending...Media file 1: (A) Magnesium reabsorption in the thick ascending limb of the loop of Henle. The driving force for the reabsorption against a concentration gradient is a lumen-positive voltage gradient generated by the reabsorption of NaCl. FHHNC = Familial hypomagnesemia with hypercalciuria and nephrocalcinosis. ADH = autosomal dominant hypocalcemia. FHH/NSHPT = Familial hypomagnesemia/neonatal severe hyperparathyroidism. (B) Magnesium reabsorption in the distal convoluted tubule. Active transcellular transport is mediated by an apical entry through a magnesium channel and a basolateral exit, presumably via a Na+/Mg2+ exchange mechanism. HSH = Hypomagnesemia with secondary hypocalcemia. GS = Gitelman syndrome. IDH = Isolated dominant hypomagnesemia. Source: Konrad M, Schlingmann KP, Gudermann T: Insights into the molecular nature of magnesium homeostasis. Am J Physiol Renal Physiol 2004; 286: F599-F605.
(A) Magnesium reabsorption in the thick ascending...

(A) Magnesium reabsorption in the thick ascending limb of the loop of Henle. The driving force for the reabsorption against a concentration gradient is a lumen-positive voltage gradient generated by the reabsorption of NaCl. FHHNC = Familial hypomagnesemia with hypercalciuria and nephrocalcinosis. ADH = autosomal dominant hypocalcemia. FHH/NSHPT = Familial hypomagnesemia/neonatal severe hyperparathyroidism. (B) Magnesium reabsorption in the distal convoluted tubule. Active transcellular transport is mediated by an apical entry through a magnesium channel and a basolateral exit, presumably via a Na+/Mg2+ exchange mechanism. HSH = Hypomagnesemia with secondary hypocalcemia. GS = Gitelman syndrome. IDH = Isolated dominant hypomagnesemia. Source: Konrad M, Schlingmann KP, Gudermann T: Insights into the molecular nature of magnesium homeostasis. Am J Physiol Renal Physiol 2004; 286: F599-F605.

More on Hypomagnesemia

Overview: Hypomagnesemia
Differential Diagnoses & Workup: Hypomagnesemia
Treatment & Medication: Hypomagnesemia
Follow-up: Hypomagnesemia
Multimedia: Hypomagnesemia
References
Further Reading

References

  1. Tong GM, Rude RK. Magnesium deficiency in critical illness. J Intensive Care Med. Jan-Feb 2005;20(1):3-17. [Medline].

  2. Curiel-Garcia JA, Rodriguez-Moran M, Guerrero-Romero F. Hypomagnesemia and mortality in patients with type 2 diabetes. Magnes Res. Sep 2008;21(3):163-6. [Medline].

  3. Guerrera MP, Volpe SL, Mao JJ. Therapeutic uses of magnesium. Am Fam Physician. Jul 15 2009;80(2):157-62. [Medline].

  4. Naderi AS, Reilly RF Jr. Hereditary etiologies of hypomagnesemia. Nat Clin Pract Nephrol. Feb 2008;4(2):80-9. [Medline].

  5. Agus ZS. Hypomagnesemia. J Am Soc Nephrol. Jul 1999;10(7):1616-22. [Medline].

  6. Konrad M. Disorders of magnesium metabolism. In: Geary D, Shaefer F. Comprehensive Pediatric Nephrology. Philadelphia PA: Mosby Elsevier; 2008:461-475.

  7. Martin KJ, Gonzalez EA, Slatopolsky E. Clinical Consequences and Management of Hypomagnesemia. J Am Soc Nephrol. Jan 30 2008;[Medline][Full Text].

  8. [Best Evidence] Mouw DR, Latessa RA, Hickner J. Clinical inquiries. What are the causes of hypomagnesemia?. J Fam Pract. Feb 2005;54(2):174-6. [Medline][Full Text].

  9. Rodriguez-Hernandez H, Gonzalez JL, Rodriguez-Moran M, Guerrero-Romero F. Hypomagnesemia, insulin resistance, and non-alcoholic steatohepatitis in obese subjects. Arch Med Res. Jul-Aug 2005;36(4):362-6. [Medline].

  10. Topf JM, Murray PT. Hypomagnesemia and hypermagnesemia. Rev Endocr Metab Disord. May 2003;4(2):195-206. [Medline].

Keywords

hypomagnesemia, magnesium, Mg, infectious diarrhea, steatorrhea, inflammatory bowel disease, GI neoplasms, diabetic ketoacidosis, irritability, disorientation, depression, psychosis, treatment, diagnosis, low magnesium levels, treatment, diagnosis

Contributor Information and Disclosures

Author

James E Springate, MD, Associate Professor of Pediatrics, State University of New York at Buffalo; Attending Physician, Department of Pediatrics, Division of Pediatric Nephrology, Women & Children's Hospital of Buffalo
James E Springate, MD is a member of the following medical societies: American Academy of Pediatrics, American Physiological Society, American Society of Pediatric Nephrology, International Pediatric Transplant Association, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Coauthor(s)

Gunjeet K Kala, MD, Clinical Instructor, Division of Pediatric Nephrology, University of Buffalo State University of New York School of Medicine and Biomedical Sciences, Women and Children's Hospital of Buffalo
Gunjeet K Kala, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Pediatric Nephrology, and American Society of Pediatric Nephrology
Disclosure: Nothing to disclose.

Medical Editor

Karl S Roth, MD, Professor and Chair, Department of Pediatrics, Creighton University School of Medicine
Karl S Roth, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American College of Nutrition, American Pediatric Society, American Society for Clinical Nutrition, American Society of Nephrology, Association of American Medical Colleges, Medical Society of Virginia, New York Academy of Sciences, Sigma Xi, Society for Pediatric Research, and Southern Society for Pediatric Research
Disclosure: MDS Pharma Salary Employment

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London), Professor and Chair, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, Greece
George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London) is a member of the following medical societies: American Academy of Pediatrics, American College of Endocrinology, American College of Physicians, American Pediatric Society, American Society for Clinical Investigation, Association of American Physicians, Endocrine Society, Lawson-Wilkins Pediatric Endocrine Society, and Society for Pediatric Research
Disclosure: Nothing to disclose.

CME Editor

David Pallares, MD, Clinical Assistant Professor, Department of Pediatrics, Division of Allergy and Immunology, University of Louisville
David Pallares, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology
Disclosure: Nothing to disclose.

Chief Editor

Stephen Kemp, MD, PhD, Professor, Department of Pediatrics, Section of Pediatric Endocrinology, University of Arkansas and Arkansas Children's Hospital
Stephen Kemp, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, American Pediatric Society, Endocrine Society, Phi Beta Kappa, Southern Medical Association, and Southern Society for Pediatric Research
Disclosure: Genentech, Inc. Honoraria Speaking and teaching; Pfizer, Inc. Honoraria Consulting

 
 
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