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Hyposomatotropism Differential Diagnoses

  • Author: Sunil Sinha, MD; Chief Editor: Stephen Kemp, MD, PhD  more...
Updated: Oct 30, 2015

Diagnostic Considerations

For primary growth disorders, include the following:

  • Osteochondrodysplasias - Group of disorders characterized by intrinsic abnormalities of cartilage and/or bone
  • Chromosomal abnormalities - Aberrations of autosomes and sex chromosomes
  • Intrauterine growth retardation - Infections, syndromes, placental abnormalities, and maternal disorders
  • Genetic short stature
  • Constitutional delay of growth and maturation

For secondary growth disorders, include the following:

  • Chronic diseases - GI, renal, cardiovascular, and autoimmune
  • Endocrine disorders - Hypothyroidism, Cushing syndrome, pseudohypoparathyroidism, growth hormone (GH) insensitivity, and insulinlike growth factor (IGF) deficiency
  • Rickets

Differential Diagnoses

Contributor Information and Disclosures

Sunil Sinha, MD Assistant Professor, Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, University of Tennessee Health Science Center

Sunil Sinha, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, Endocrine Society, Pediatric Endocrine Society

Disclosure: Nothing to disclose.


Sherry L Franklin, MD, FAAP Medical Director, Pediatric Endocrinology of San Diego Medical Group, Inc; Assistant Clinical Professor, University of California, San Diego, School of Medicine

Sherry L Franklin, MD, FAAP is a member of the following medical societies: American Academy of Pediatrics, Pediatric Endocrine Society, American Diabetes Association, American Medical Association, Endocrine Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London) Professor and Chair, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, Greece; UNESCO Chair on Adolescent Health Care, University of Athens, Greece

George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London) is a member of the following medical societies: American Academy of Pediatrics, American College of Physicians, American Pediatric Society, American Society for Clinical Investigation, Association of American Physicians, Endocrine Society, Pediatric Endocrine Society, Society for Pediatric Research, American College of Endocrinology

Disclosure: Nothing to disclose.

Chief Editor

Stephen Kemp, MD, PhD Former Professor, Department of Pediatrics, Section of Pediatric Endocrinology, University of Arkansas for Medical Sciences College of Medicine, Arkansas Children's Hospital

Stephen Kemp, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, American Pediatric Society, Endocrine Society, Phi Beta Kappa, Southern Medical Association, Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Additional Contributors

Phyllis W Speiser, MD Chief, Division of Pediatric Endocrinology, Steven and Alexandra Cohen Children's Medical Center of New York; Professor of Pediatrics, Hofstra-North Shore LIJ School of Medicine at Hofstra University

Phyllis W Speiser, MD is a member of the following medical societies: American Association of Clinical Endocrinologists, Endocrine Society, Pediatric Endocrine Society, Society for Pediatric Research

Disclosure: Nothing to disclose.


Robert J Ferry Jr, MD Le Bonheur Chair of Excellence in Endocrinology, Professor and Chief, Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, University of Tennessee Health Science Center

Robert J Ferry Jr, MD is a member of the following medical societies: American Academy of Pediatrics, American Diabetes Association, American Medical Association, Endocrine Society, Pediatric Endocrine Society, Society for Pediatric Research, and Texas Pediatric Society

Disclosure: Eli Lilly & Co Grant/research funds Investigator; MacroGenics, Inc Grant/research funds Investigator; Ipsen, SA (formerly Tercica, Inc) Grant/research funds Investigator; NovoNordisk SA Grant/research funds Investigator; Diamyd Grant/research funds Investigator; Bristol-Myers-Squibb Grant/research funds Other; Amylin Other; Pfizer Grant/research funds Other; Takeda Grant/research funds Other


The authors thank Gloria Matthews, Nora Eblen, and Debra Tate of the Division of Pediatric Endocrinology, University of Texas Health Science Center at San Antonio, for their administrative assistance. This work was supported in part by National Institutes of Health (NIH) grant K08 DK02876.

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T1-weighted sagittal MRI through the pituitary fossa shows a normal pituitary gland.
Table. Characteristics of the Pubertal Peak of Growth Velocity in Girls and Boys
Mean age at peak height velocity, y11.513
Magnitude, cm/y8.59.5
Duration, y56
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