Pediatric Growth Hormone Deficiency Differential Diagnoses

  • Author: Stephen Kemp, MD, PhD; Chief Editor: Bruce Buehler, MD   more...
 
Updated: Apr 17, 2012
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Stephen Kemp, MD, PhD  Professor, Department of Pediatrics, Section of Pediatric Endocrinology, University of Arkansas for Medical Sciences College of Medicine, Arkansas Children's Hospital

Stephen Kemp, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, American Pediatric Society, Endocrine Society, Phi Beta Kappa, Southern Medical Association, and Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Specialty Editor Board

Arlan L Rosenbloom, MD  Adjunct Distinguished Service Professor Emeritus of Pediatrics, University of Florida College of Medicine; Fellow of the American Academy of Pediatrics; Fellow of the American College of Epidemiology

Arlan L Rosenbloom, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Epidemiology, American Pediatric Society, Endocrine Society, Florida Pediatric Society, Pediatric Endocrine Society, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Barry B Bercu, MD  Professor, Departments of Pediatrics, Molecular Pharmacology and Physiology, University of South Florida College of Medicine, All Children's Hospital

Barry B Bercu, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, American Federation for Clinical Research, American Medical Association, American Pediatric Society, Association of Clinical Scientists, Endocrine Society, Florida Medical Association, Pediatric Endocrine Society, Pituitary Society, Society for Pediatric Research, Society for the Study of Reproduction, and Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Merrily P M Poth, MD  Professor, Department of Pediatrics and Neuroscience, Uniformed Services University of the Health Sciences

Merrily P M Poth, MD is a member of the following medical societies: American Academy of Pediatrics, Endocrine Society, and Pediatric Endocrine Society

Disclosure: Nothing to disclose.

Chief Editor

Bruce Buehler, MD  Professor, Department of Pediatrics and Genetics, Director RSA, University of Nebraska Medical Center

Bruce Buehler, MD is a member of the following medical societies: American Academy for Cerebral Palsy and Developmental Medicine, American Academy of Pediatrics, American Association on Mental Retardation, American College of Medical Genetics, American College of Physician Executives, American Medical Association, and Nebraska Medical Association

Disclosure: Nothing to disclose.

References

  1. Mills JL, Schonberger LB, Wysowski DK. Long-term mortality in the United States cohort of pituitary-derived growth hormone recipients. J Pediatr. Apr 2004;144(4):430-6. [Medline].

  2. Rainbow LA, Rees SA, Shaikh MG. Mutation analysis of POUF-1, PROP-1 and HESX-1 show low frequency of mutations in children with sporadic forms of combined pituitary hormone deficiency and septo-optic dysplasia. Clin Endocrinol (Oxf). Feb 2005;62(2):163-8. [Medline].

  3. Blethen SL, Allen DB, Graves D. Safety of recombinant deoxyribonucleic acid-derived growth hormone: The National Cooperative Growth Study experience. J Clin Endocrinol Metab. May 1996;81(5):1704-10. [Medline].

  4. Frindik JP, Baptista J. Adult height in growth hormone deficiency: historical perspective and examples from the national cooperative growth study. Pediatrics. Oct 1999;104(4 Pt 2):1000-4. [Medline].

  5. Root AW, Kemp SF, Rundle AC. Effect of long-term recombinant growth hormone therapy in children--the National Cooperative Growth Study. J Pediatr Endocrinol Metab. 1998;11:403-12.

  6. Carel JC, Ecosse E, Landier F, et al. Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study. J Clin Endocrinol Metab. Feb 2012;97(2):416-25. [Medline].

  7. Sävendahl L, Maes M, Albertsson-Wikland K, et al. Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study. J Clin Endocrinol Metab. Feb 2012;97(2):E213-7. [Medline].

  8. Lindsay R, Feldkamp M, Harris D. Utah Growth Study: growth standards and the prevalence of growth hormone deficiency. J Pediatr. Jul 1994;125(1):29-35. [Medline].

  9. Cuttler L, Silvers JB, Singh J, Marrero U, Finkelstein B, Tannin G, et al. Short stature and growth hormone therapy. A national study of physician recommendation patterns. JAMA. Aug 21 1996;276(7):531-7. [Medline].

  10. Grimberg A, Stewart E, Wajnrajch MP. Gender of pediatric recombinant human growth hormone recipients in the United States and globally. J Clin Endocrinol Metab. Jun 2008;93(6):2050-6. [Medline].

  11. Mayer M, Schmitt K, Kapelari K, Frisch H, Köstl G, Voigt M. Spontaneous Growth in Growth Hormone Deficiency from Birth until 7 Years of Age: Development of Disease-Specific Growth Curves. Horm Res Paediatr. Apr 29 2010;[Medline].

  12. Tanner JM, Whitehouse RH, Hughes PC. Effect of human growth hormone treatment for 1 to 7 years on growth of 100 children, with growth hormone deficiency, low birthweight, inherited smallness, Turner's syndrome, and other complaints. Arch Dis Child. Dec 1971;46(250):745-82. [Medline].

  13. Wilson DM, Baker B, Hintz RL, Rosenfeld RG. Subcutaneous versus intramuscular growth hormone therapy: growth and acute somatomedin response. Pediatrics. Sep 1985;76(3):361-4. [Medline].

  14. Milner RD, Russell-Fraser T, Brook CG, Cotes PM, Farquhar JW, Parkin JM, et al. Experience with human growth hormone in Great Britain: the report of the MRC Working Party. Clin Endocrinol (Oxf). Jul 1979;11(1):15-38. [Medline].

  15. Albertsson-Wikland K, Westphal O, Westgren U. Daily subcutaneous administration of human growth hormone in growth hormone deficient children. Acta Paediatr Scand. Jan 1986;75(1):89-97. [Medline].

  16. Jørgensen JO, Moler N, Lauritzen T, Alberti KG, Orskov H, Christiansen JS. Evening versus morning injections of growth hormone (GH) in GH-deficient patients: effects on 24-hour patterns of circulating hormones and metabolites. J Clin Endocrinol Metab. Jan 1990;70(1):207-14. [Medline].

  17. Kastrup KW, Christiansen JS, Andersen JK, Orskov H. Increased growth rate following transfer to daily sc administration from three weekly im injections of hGH in growth hormone deficient children. Acta Endocrinol (Copenh). Oct 1983;104(2):148-52. [Medline].

  18. MacGillivray MH, Baptista J, Johanson A. Outcome of a four-year randomized study of daily versus three times weekly somatropin treatment in prepubertal naive growth hormone-deficient children. Genentech Study Group. J Clin Endocrinol Metab. May 1996;81(5):1806-9. [Medline].

  19. Sas TC, de Ridder MA, Wit JM, et al. Adult Height in Children with Growth Hormone Deficiency: A Randomized, Controlled, Growth Hormone Dose-Response Trial. Horm Res Paediatr. Apr 24 2010;[Medline].

  20. Blethen SL, Compton P, Lippe BM. Factors predicting the response to growth hormone (GH) therapy in prepubertal children with GH deficiency. J Clin Endocrinol Metab. Mar 1993;76(3):574-9. [Medline].

  21. Cheng JC, Leung SS, Lau J. Anthropometric measurements and body proportions among Chinese children. Clin Orthop. Feb 1996;(323):22-30. [Medline].

  22. Frasier SD. A preview of growth hormone stimulation tests in children. Pediatrics. Jun 1974;53(6):929-37. [Medline].

  23. Frasier SD, Costin G, Lippe BM. A dose-response curve for human growth hormone. J Clin Endocrinol Metab. Dec 1981;53(6):1213-7. [Medline].

  24. Frindik JP, Kemp SF, Pihoker C. Effective use of magnetic resonance imaging in the assessment of children with possible growth hormone deficiency. Endocrine Practice. 1996;2:8-12.

  25. Hintz RL. The prismatic case of Creutzfeldt-Jakob disease associated with pituitary growth hormone treatment. J Clin Endocrinol Metab. Aug 1995;80(8):2298-301. [Medline].

  26. Kemp SF. Growth hormone therapeutic practice: dosing issues. The Endocrinologist. 1996;6:231-7.

  27. Mayer M, Schmitt K, Kapelari K, et al. Spontaneous Growth in Growth Hormone Deficiency from Birth until 7 Years of Age: Development of Disease-Specific Growth Curves. Horm Res Paediatr. Apr 29 2010;[Medline].

  28. Rabin MS. Treatment of a pituitary dwarf with human growth hormone. J Clin Endrocrinol Metab. 1958;18:901-3.

  29. Reiter EO, Martha PM Jr. Pharmacological testing of growth hormone secretion. Horm Res. 1990;33(2-4):121-6; discussion 126-7. [Medline].

  30. Rosenbloom AL, Knuth C, Shulman D. Growth hormone therapy by daily injection in patients previously treated for growth hormone deficiency. South Med J. 1980;83:653-5.

  31. Rosenfeld RG, Albertsson-Wikland K, Cassorla F. Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab. May 1995;80(5):1532-40. [Medline].

  32. Rosenfeld RG, Wilson DM, Lee PD. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr. Sep 1986;109(3):428-33. [Medline].

  33. Siklar Z, Tuna C, Dallar Y, Tanyer G. Zinc deficiency: a contributing factor of short stature in growth hormone deficient children. J Trop Pediatr. Jun 2003;49(3):187-8. [Medline].

 
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