eMedicine Specialties > Pediatrics: General Medicine > Endocrinology

Syndrome of Inappropriate Antidiuretic Hormone Secretion: Multimedia

Author: Robert J Ferry Jr, MD,, Chief, Division of Pediatric Endocrinology and Metabolism, Le Bonheur Children's Medical Center, University of Tennessee Health Science Center at Memphis, and St. Jude Children's Research Hospital; Brigade Surgeon, 36th Sustainment Brigade, 13th Expeditionary Sustainment Command, U.S. Army
Coauthor(s): Jose F Pascual-y-Baralt, MD, Chief, Division of Pediatric Nephrology, San Antonio Military Pediatric Center; Clinical Professor, Department of Pediatrics, University of Texas Health Science Campus
Contributor Information and Disclosures

Updated: Oct 22, 2009

Multimedia

Disorders associated with syndrome of inappropria...Media file 1: Disorders associated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
Disorders associated with syndrome of inappropria...

Disorders associated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

Drugs that impair water excretion.Media file 2: Drugs that impair water excretion.
Drugs that impair water excretion.

Drugs that impair water excretion.

Cerebral salt-wasting syndrome (CSWS) versus synd...Media file 3: Cerebral salt-wasting syndrome (CSWS) versus syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
Cerebral salt-wasting syndrome (CSWS) versus synd...

Cerebral salt-wasting syndrome (CSWS) versus syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

More on Syndrome of Inappropriate Antidiuretic Hormone Secretion

Overview: Syndrome of Inappropriate Antidiuretic Hormone Secretion
Differential Diagnoses & Workup: Syndrome of Inappropriate Antidiuretic Hormone Secretion
Treatment & Medication: Syndrome of Inappropriate Antidiuretic Hormone Secretion
Follow-up: Syndrome of Inappropriate Antidiuretic Hormone Secretion
Multimedia: Syndrome of Inappropriate Antidiuretic Hormone Secretion
References

References

  1. Kaplan SL, Feigin RD. The syndrome of inappropriate secretion of antidiuretic hormone in children with bacterial meningitis. J Pediatr. May 1978;92(5):758-61. [Medline].

  2. Bartter FC, Schwartz WB. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. May 1967;DA - 19670701(5):790-806. [Medline].

  3. Rianthavorn P, Cain JP, Turman MA. Use of conivaptan to allow aggressive hydration to prevent tumor lysis syndrome in a pediatric patient with large-cell lymphoma and SIADH. Pediatr Nephrol. Apr 24 2008;[Medline].

  4. Al-Mufti H, Arieff AI. Hyponatremia due to cerebral salt-wasting syndrome. Combined cerebral and distal tubular lesion. Am J Med. Oct 1984;77(4):740-6. [Medline].

  5. Arieff AI. Central nervous system manifestations of disordered sodium metabolism. Clin Endocrinol Metab. Jul 1984;13(2):269-94. [Medline].

  6. Arieff AI. Hyponatremia, convulsions, respiratory arrest, and permanent brain damage after elective surgery in healthy women. N Engl J Med. Jun 12 1986;314(24):1529-35. [Medline].

  7. Arieff AI, Ayus JC, Fraser CL. Hyponatremia and death or permanent brain damage in healthy children. BMJ. May 9 1992;304(6836):1218-22. [Medline].

  8. Ayus JC, Wheeler JM, Arieff AI. Postoperative hyponatremic encephalopathy in menstruant women. Ann Intern Med. Dec 1 1992;117(11):891-7. [Medline].

  9. Beck LH. Hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med. 1979;301:528-30. [Medline].

  10. Benson H, Akbarian M, Adler LN. Hemodynamic effects of pneumonia. I. Normal and hypodynamic responses. J Clin Invest. Apr 1970;49(4):791-8. [Medline].

  11. Braden GL, Geheb MA, Shook A. Demeclocycline-induced natriuresis and renal insufficiency: in vivo and in vitro studies. Am J Kidney Dis. May 1985;5(5):270-7. [Medline].

  12. Brewerton TD, Jackson CW. Prophylaxis of carbamazepine-induced hyponatremia by demeclocycline in six patients. J Clin Psychiatry. 1994;55:249-51. [Medline].

  13. Burrows FA, Shutack JG, Crone RK. Inappropriate secretion of antidiuretic hormone in a postsurgical pediatric population. Crit Care Med. Jul 1983;11(7):527-31. [Medline].

  14. Cogan E, Debieve MF, Pepersack T. Natriuresis and atrial natriuretic factor secretion during inappropriate antidiuresis. Am J Med. Mar 1988;84(3 Pt 1):409-18. [Medline].

  15. David R, Ellis D, Gartner JC. Water intoxication in normal infants: role of antidiuretic hormone in pathogenesis. Pediatrics. Sep 1981;68(3):349-53. [Medline].

  16. De Troyer A, Demanet JC. Correction of antidiuresis by demeclocycline. N Engl J Med. Oct 30 1975;293(18):915-8. [Medline].

  17. Decaux G, Musch W. Clinical laboratory evaluation of the syndrome of inappropriate secretion of antidiuretic hormone. Clin J Am Soc Nephrol. Apr 23 2008;[Medline].

  18. Decaux G, Waterlot Y, Genette F. Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with furosemide. N Engl J Med. Feb 5 1981;304(6):329-30. [Medline].

  19. Dubovsky SL, Grabon S, Berl T. Syndrome of inappropriate secretion of antidiuretic hormone with exacerbated psychosis. Ann Intern Med. Oct 1973;79(4):551-4. [Medline].

  20. Feigin RD. Interaction of nutrition and infection: plans for future research. Am J Clin Nutr. Sep 1977;30(9):1553-63. [Medline].

  21. Ferry RJ Jr, Kesavulu V, Kelly A, Levitt Katz LE, Moshang T Jr. Hyponatremia and polyuria in children with central diabetes insipidus: challenges in diagnosis and management. J Pediatr. 2001;138:744-7. [Medline].

  22. Friedman AL, Segar WE. Antidiuretic hormone excess. J Pediatr. 1979;94:521-526. [Medline].

  23. Ganong CA, Kappy MS. Cerebral salt wasting in children. The need for recognition and treatment [published erratum appears in Am J Dis Child 1993 Apr;147(4):369]. Am J Dis Child. Feb 1993;147(2):167-9. [Medline].

  24. Glassock RJ, Cohen AH, Danovitch G. Human immunodeficiency virus (HIV) infection and the kidney [published erratum appears in Ann Intern Med 1990 Mar 15;112(6):476]. Ann Intern Med. Jan 1 1990;112(1):35-49. [Medline].

  25. Hantman D, Rossier B, Zohlman R. Rapid correction of hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone. An alternative treatment to hypertonic saline. Ann Intern Med. Jun 1973;78(6):870-5. [Medline].

  26. Harrigan MR. Cerebral salt wasting syndrome: a review. Neurosurgery. Jan 1996;38:152-60. [Medline].

  27. Haycock GB. The syndrome of inappropriate secretion of antidiuretic hormone. Pediatr Nephrol. Jun 1995;9:375-81. [Medline].

  28. Huang EA, Feldman BJ, Schwartz ID, et al. Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. J Pediatr. Jan 2006;148(1):128-31. [Medline].

  29. Ishikawa S, Schrier RW. Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats. Kidney Int. Dec 1982;22(6):587-93. [Medline].

  30. Janss AJ, Heller G, Grimberg A, Ferry RJ Jr. Neuro-oncology-endocrinology interface: a patient who earned her salt. Med Pediatr Oncol. Oct 1999;33(4):413-7. [Medline].

  31. Kamoi K, Ebe T, Kobayashi O. Atrial natriuretic peptide in patients with the syndrome of inappropriate antidiuretic hormone secretion and with diabetes insipidus. J Clin Endocrinol Metab. May 1990;70(5):1385-90. [Medline].

  32. Laureno R. Central pontine myelinolysis following rapid correction of hyponatremia. Ann Neurol. 1983;13:232-234. [Medline].

  33. Linas SL, Berl T, Robertson GL. Role of vasopressin in the impaired water excretion of glucocorticoid deficiency. Kidney Int. Jul 1980;18(1):58-67. [Medline].

  34. Liskin B, Walsh BT, Roose SP. Imipramine-induced inappropriate ADH secretion. J Clin Psychopharmacol. Jun 1984;4(3):146-7. [Medline].

  35. Lowance DC, Garfinkel HB, Mattern WD. The effect of chronic hypotonic volume expansion on the renal regulation of acid-base equilibrium. J Clin Invest. Nov 1972;51(11):2928-40. [Medline].

  36. Manoogian C, Pandian M, Ehrlich L. Plasma atrial natriuretic hormone levels in patients with the syndrome of inappropriate antidiuretic hormone secretion. J Clin Endocrinol Metab. Sep 1988;67(3):571-5. [Medline].

  37. Maramattom BV. Duloxetine-induced syndrome of inappropriate antidiuretic hormone secretion and seizures. Neurology. Mar 14 2006;66(5):773-4. [Medline].

  38. McDade G. Disorders of sodium balance: hyponatraemia and drug use (and abuse). BMJ. Apr 8 2006;332(7545):853. [Medline].

  39. Mendoza SA. Syndrome of inappropriate antidiuretic hormone secretion (SIADH). Pediatr Clin North Am. Nov 1976;DA - 19770125(4):681-90. [Medline].

  40. Mor J, Ben-Galim E, Abrahamov A. Inappropriate antidiuretic hormone secretion in an infant with severe pneumonia. Am J Dis Child. Jan 1975;129(1):133-5. [Medline].

  41. Moylan FM, Herrin JT, Krishnamoorthy K. Inappropriate antidiuretic hormone secretion in premature infants with cerebral injury. Am J Dis Child. Apr 1978;132(4):399-402. [Medline].

  42. Neville KA, Verge CF, O'Meara MW, Walker JL. High antidiuretic hormone levels and hyponatremia in children with gastroenteritis. Pediatrics. Dec 2005;116(6):1401-7. [Medline].

  43. Nolph KD, Schrier RW. Sodium, potassium and water metabolism in the syndrome of inappropriate antidiuretic hormone secretion. Am J Med. Oct 1970;49(4):534-45. [Medline].

  44. Norlela S, Azmi KN, Khalid BA. Syndrome of inappropriate antidiuretic hormone caused by continuous lumbar spinal fluid drainage after transphenoidal surgery. Singapore Med J. Jan 2006;47(1):75-6. [Medline].

  45. Passamonte PM. Hypouricemia, inappropriate secretion of antidiuretic hormone, and small cell carcinoma of the lung. Arch Intern Med. Aug 1984;144(8):1569-70. [Medline].

  46. Paxson CL Jr, Stoerner JW, Denson SE. Syndrome of inappropriate antidiuretic hormone secretion in neonates with pneumothorax or atelectasis. J Pediatr. Sep 1977;91(3):459-63. [Medline].

  47. Powell KR, Sugarman LI, Eskenazi AE. Normalization of plasma arginine vasopressin concentrations when children with meningitis are given maintenance plus replacement fluid therapy. J Pediatr. Oct 1990;117(4):515-22. [Medline].

  48. Rascher W, Tulassay T, Lang RE. Atrial natriuretic peptide in plasma of volume-overloaded children with chronic renal failure. Lancet. Aug 10 1985;2(8450):303-5. [Medline].

  49. Raskind M, Barnes F. Water metabolism in psychiatric disorders. Sem Nephrol. 1984;4:316.

  50. Robertson GL. Physiology of ADH secretion. Kidney Int Suppl. Aug 1987;21:S20-6. [Medline].

  51. Robertson GL, Shelton RL, Athar S. The osmoregulation of vasopressin. Kidney Int. 1976;10:25-37. [Medline].

  52. Rose BD. New approach to disturbances in the plasma sodium concentration. Am J Med. Dec 1986;81(6):1033-40. [Medline].

  53. Schrier RW, Bichet DG. Osmotic and nonosmotic control of vasopressin release and the pathogenesis of impaired water excretion in adrenal, thyroid, and edematous disorders. J Lab Clin Med. Jul 1981;DA - 19810915(1):1-15. [Medline].

  54. Schwartz WB, Bennett W, Curelop S. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med. 1957;23:529-42.

  55. Sklar C, Fertig A, David R. Chronic syndrome of inappropriate secretion of antidiuretic hormone in childhood. Am J Dis Child. Jul 1985;139(7):733-5. [Medline].

  56. Sordillo P, Sagransky DM, Mercado RM. Carbamazepine-induced syndrome of inappropriate antidiuretic hormone secretion. Reversal by concomitant phenytoin therapy. Arch Intern Med. Feb 1978;138(2):299-301. [Medline].

  57. Streefkerk JO, van Zwieten PA. Vasopressin receptor antagonists: pharmacological tools and potential therapeutic agents. Auton Autacoid Pharmacol. Apr 2006;26(2):141-8. [Medline].

  58. Tho LM, Ferry DR. Is the paraneoplastic syndrome of inappropriate antidiuretic hormone secretion in lung cancer always attributable to the small cell variety?. Postgrad Med J. Nov 2005;81(961):e17. [Medline].

  59. Ting S, Eshaghpour E. Inappropriate secretion of antidiuretic hormone after open heart surgery. Am J Dis Child. 1980;134:873-4. [Medline].

  60. Tisdall M, Crocker M, Watkiss J, Smith M. Disturbances of sodium in critically ill adult neurologic patients: a clinical review. J Neurosurg Anesthesiol. Jan 2006;18(1):57-63. [Medline].

  61. Verbalis JG. An experimental model of syndrome of inappropriate antidiuretic hormone secretion in the rat. Am J Physiol. Oct 1984;247(4 Pt 1):E540-53. [Medline].

  62. Weinberg MS, Donohue JF. Hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone: Rapid correction with osmotic agents. South Med J. 1984;78:348-351. [Medline].

  63. Weizman Z, Goitein K, Amit Y, et al. Combined treatment of severe hyponatremia due to inappropriate antidiuretic hormone secretion. Pediatrics. May 1982;69(5):610-2. [Medline].

  64. Zerbe R, Stropes L, Robertson G. Vasopressin function in the syndrome of inappropriate antidiuresis. Annu Rev Med. 1980;31:315-27. [Medline].

Further Reading

Keywords

syndrome of inappropriate antidiuretic hormone secretion, SIADH, euvolemic hyponatremia, arginine vasopressin, vasopressin secretion, osmoregulatory defect, hypervolemia, hypotonic normovolemic hyponatremia, cerebral edema, hyponatremic encephalopathy, brain injury, treatment, diagnosis

Contributor Information and Disclosures

Author

Robert J Ferry Jr, MD,, Chief, Division of Pediatric Endocrinology and Metabolism, Le Bonheur Children's Medical Center, University of Tennessee Health Science Center at Memphis, and St. Jude Children's Research Hospital; Brigade Surgeon, 36th Sustainment Brigade, 13th Expeditionary Sustainment Command, U.S. Army
Robert J Ferry Jr, MD, is a member of the following medical societies: American Academy of Pediatrics, American Diabetes Association, American Medical Association, Endocrine Society, Lawson-Wilkins Pediatric Endocrine Society, Society for Pediatric Research, and Texas Pediatric Society
Disclosure: Nutropin Speakers Bureau Honoraria Speaking and teaching; Genotropin Speakers Bureau Honoraria Speaking and teaching; Eli Lilly & Co. Grant/research funds Independent contractor; MacroGenics, Inc. Grant/research funds Independent contractor; Ipsen, S.A. (formerly Tercica, Inc.) Grant/research funds Independent contractor

Coauthor(s)

Jose F Pascual-y-Baralt, MD, Chief, Division of Pediatric Nephrology, San Antonio Military Pediatric Center; Clinical Professor, Department of Pediatrics, University of Texas Health Science Campus
Jose F Pascual-y-Baralt, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, American Society of Pediatric Nephrology, Association of Military Surgeons of the US, and International Society of Nephrology
Disclosure: Nothing to disclose.

Medical Editor

Arlan L Rosenbloom, MD, Adjunct Distinguished Service Professor Emeritus of Pediatrics, University of Florida; Fellow of the American Academy of Pediatrics; Fellow of the American College of Epidemiology
Arlan L Rosenbloom, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Epidemiology, American Pediatric Society, Endocrine Society, Florida Pediatric Society, Lawson-Wilkins Pediatric Endocrine Society, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

Lynne Lipton Levitsky, MD, Chief, Pediatric Endocrine Unit, Massachusetts General Hospital; Associate Professor, Department of Pediatrics, Harvard University Medical School
Lynne Lipton Levitsky, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Diabetes Association, American Pediatric Society, Endocrine Society, Lawson-Wilkins Pediatric Endocrine Society, and Society for Pediatric Research
Disclosure: Pfizer Grant/research funds P.I.; Tercica Grant/research funds PI, also occasional consultant

CME Editor

Merrily P M Poth, MD, Professor, Department of Pediatrics and Neuroscience, Uniformed Services University of the Health Sciences
Merrily P M Poth, MD is a member of the following medical societies: American Academy of Pediatrics, Endocrine Society, and Lawson-Wilkins Pediatric Endocrine Society
Disclosure: Nothing to disclose.

Chief Editor

Stephen Kemp, MD, PhD, Professor, Department of Pediatrics, Section of Pediatric Endocrinology, University of Arkansas and Arkansas Children's Hospital
Stephen Kemp, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, American Pediatric Society, Endocrine Society, Phi Beta Kappa, Southern Medical Association, and Southern Society for Pediatric Research
Disclosure: Genentech, Inc. Honoraria Speaking and teaching; Pfizer, Inc. Honoraria Consulting

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.