- Author: Adam C Alder, MD; Chief Editor: Carmen Cuffari, MD more...
Acute appendicitis is acute inflammation and infection of the vermiform appendix, which is most commonly referred to simply as the appendix. The appendix is a blind-ending structure arising from the cecum. Acute appendicitis is one of the most common causes of abdominal pain and is the most frequent condition leading to emergent abdominal surgery in children. The appendix may be involved in other infectious, inflammatory, or chronic processes that can lead to appendectomy; however, this article focuses on acute appendicitis. Appendicitis and acute appendicitis are used interchangeably. (See Anatomy, as well as Pathophysiology.)
Images of pediatric appendicitis are provided below.
See Appendicitis: Avoiding Pitfalls in Diagnosis, a Critical Images slideshow, to help make an accurate diagnosis.
Also see the 12 Can't-Miss Findings on Pediatric Imaging Studies slideshow to help correctly evaluate abnormal findings in imaging studies for pediatric patients.
Common symptoms of acute appendicitis include abdominal pain, fever, and vomiting. The diagnosis of appendicitis can be difficult in children because the classic symptoms are often not present. (See Clinical Presentation.)
A delay in the diagnosis of appendicitis is associated with rupture and associated complications, especially in young children. Improvements in rupture rates have been made with advanced radiologic imaging. Appendicitis is a clinical diagnosis with imaging used to confirm equivocal cases. (See Workup.)
The definitive treatment for appendicitis is currently appendectomy. Initiation of antibiotics upon diagnosis is critical to initiate treatment, slow the infectious process and prevent progression of a nonperforated appendix. Key to any evaluation and treatment plan are the following: relieve the patient's pain and discomfort early and consistently; communicate with the patient and family about the plans; repeat the examination often; adjust the differential diagnosis as appropriate; and keep the patient for observation if a firm diagnosis is not made. (See Treatment and Management.)
The most widely used antibiotic regimen is a penecillin based regimen such as piperacillin/tazobactam or ampicillin/clavulanic acid or the combination of ampicillin, clindamycin (or metronidazole), and gentamicin. If a penicillin allergy exists, regimens incluidng cephalosporins, aminoglycosides and clindamycin may be used. (See Medication.)
The vermiform appendix is generally 5-10 cm in length. It arises from the cecum, which in most children is located in the right lower quadrant of the abdomen.
Although the base of the appendix is fixed to the cecum, the tip can be located in the pelvis, retrocecum, or extraperitoneum. Note that the anatomic position of the appendix determines the symptoms and the site of tenderness when the appendix becomes inflamed. Because the visceral nerve fibers associated with the appendix typically become inflamed first, there is often vague and referred symptoms to the periumbilical region through the T10 dermatome. As the somatic sensory fibers of the peritoneal lining become involved in the inflammatory process, the pain will frequently shift to the right lower abdomen and tenderness is focused at the site of inflammation.
The appendix is lined by typical colonic epithelium. The submucosa contains lymphoid follicles, which are very few at birth. This number gradually increases to a peak of about 200 follicles at age 10-20 years and then subsequently declines. In persons older than 30 years, less than half that number is present, and the number continues to decrease throughout adulthood. The appendix may act as a reservoir for the flora of the gut which may aid in recovery from intestinal infections. However, this function is not vital for life and removal of the appendix is well tolerated.
Tradition holds that once the appendix becomes obstructed, bacteria trapped within the appendiceal lumen begin to multiply, and the appendix becomes distended. The increased intraluminal pressure obstructs venous drainage, and the appendix becomes congested and ischemic.
The combination of bacterial infection and ischemia produce inflammation, which progresses to necrosis and gangrene. When the appendix becomes gangrenous, it may perforate. The progression from obstruction to perforation usually takes place over 72 hours.
One study noted that appendiceal perforation is more common in children, specifically younger children, than in adults. A substantial risk of perforation within 24 hours of onset was noted (7.7%) and was found to increase with duration of symptoms. While perforation was directly related to the duration of symptoms before surgery, the risk was associated more with prehospital delay than with in-hospital delay.
During the initial stage of appendicitis, the patient may feel only periumbilical pain due to the T10 innervation of the appendix. As the inflammation worsens, an exudate forms on the appendiceal serosal surface. When the exudate touches the parietal peritoneum, a more intense and localized pain develops.
Perforation results in the release of inflammatory fluid and bacteria into the abdominal cavity. This further inflames the peritoneal surface, and peritonitis develops. The location and extent of peritonitis (diffuse or localized) depends on the degree to which the omentum and adjacent bowel loops can contain the spillage of luminal contents.
If the contents become walled off and form an abscess, the pain and tenderness may be localized to the abscess site. If the contents are not walled off and the fluid is able to travel throughout the peritoneum, the pain and tenderness become generalized.
Acute appendicitis is a complex disease with quite a bit of variability in presentation and pathophysiology. Several theories have been promoted to explain the etiology, epidemiology and natural history of the disease. Many contend that appendicitis is due to obstruction of the blind ending appendix, resulting in a closed loop. In children, obstruction usually results from lymphoid hyperplasia of the submucosal follicles. The cause of this hyperplasia is controversial, but dehydration and viral infection have been proposed. Another common cause of obstruction of the appendix is a fecalith.
Rare causes include foreign bodies, parasitic infections (eg, nematodes), and inflammatory strictures.
The obstructive theory of appendicitis is widely taught but may not explain all the data regarding providers' experience with this common disease. Outbreaks and clusters of appendicitis have been reported making a true infectious etiology a possible etiologic agent. Appendicitis seems to run in families with first degree relatives of those who have had appendicitis being at a much higher risk of developing the condition which suggests an role of the host genetics. Finally, perforated and non-perforated appendicitis, which should be linked by the progression from early to late appendicitis, appear to act epidemiologically as two separate disease processes. Even though appendicitis is very common, much is not understood about the etiology or pathophysiology of this disease process.
Appendicitis has an incidence of 70,000 pediatric cases per year in the United States. The incidence between birth and age 4 years is 1-2 cases per 10,000 children per year. The incidence increases to 25 cases per 10,000 children per year between 10 and 17 years of age. Overall, 7% of people in the United States have their appendix removed during their lifetime. The male-to-female ratio is approximately 2:1.
Appendicitis is much more common in developed countries. Although the reason for this discrepancy is unknown, potential risk factors include a diet low in fiber and high in sugar, family history, and infection. Gut flora and exposure to gastrointestinal infections have also been proposed as a hygiene theory of appendicitis. There may also be a role of the genetics of the host and the microbiome of the gut in the development of appendicitis and, possibly, with the risk of perforated appendicitis.
Appendicitis occurs in all age groups but is rare in infants. Appendicitis is most common in the second decade of life (age 10-19 y), occurring at a rate of 23.3 cases per 10,000 per year. Thereafter, the incidence continues to decline, although appendicitis occurs in adulthood and into old age.
Interestingly, non-perforated appendicitis and perforated appendicitis are not linked when the epidemiology of the diseases is explored. The incidence for these two diagnoses differs over time suggesting that they are potentially unrelated to each other and may represent different pathologic processes. Similarities have been shown to other diseases such as diverticulitis and even hospital admissions for influenza.
Generally, the prognosis is excellent. At the time of diagnosis, the rate of appendiceal perforation is 20-35%. The rate of perforation is 80-100% for children younger than 3 years, compared with 10-20% in children 10-17 years old. Children with ruptured appendicitis are at risk for intra-abdominal abscess formation and small bowel obstruction, and they can have a prolonged hospital stay (several weeks or more). The mortality rate for children with appendicitis is 0.1-1%.
Initiation of antibiotics represents the single most critical step in the treatment of acute appendicitis. Multiple studies in children report safety and no increase in rates of perforation once antibiotics are initiated even if the appendectomy is delay to the next morning. Commonly, the most advanced cases of acute appendicitis are managed exclusively with antibiotics with the appendectomy delayed for several weeks to months, the so-called interval appendectomy. Data is mounting to expand this approach of using just antibiotics for the acute episode of appendicitis to all types of appendicitis. Many centers are pursuing this approach in ongoing research trials.
Death from appendicitis is most common in neonates and infants for the following 2 reasons:
Appendicitis is rare in this age group; thus, unless the physician’s index of suspicion is high, appendicitis is often low on the list of suspected differential diagnoses.
Very young patients are unable to communicate the location and nature of their pain. Some neonates may not even become febrile. Often, the patient’s only symptom is irritability or inconsolability.
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