Laboratory Studies
Laboratory studies are usually not indicated in colic unless the physician suspects another condition, such as gastroesophageal reflux.
If the patient's stools are excessively watery, testing them for excess reducing substances (Clinitest) may be worthwhile. If results are positive, this may be an indication of an underlying GI problem, such as acquired (postinfectious) lactose intolerance. Stool may be tested for occult blood to rule out cow's milk allergy (CMA).
Irritability and crying may be associated with gastroesophageal reflux disease because of the pain associated with esophagitis.
Wessel MA, Cobb JC, Jackson EB. Paroxysmal fussing in infancy, sometimes called "colic". Pediatr. 1954;14:721.
Sondergaard C, Olsen J, Friis-Hasche. Psychological distress during pregnancy and the risk of infantile colic:a follo-up study. Acta Paediatrica. 2003;92(7):811-816. [Medline].
Cohen-Silver J, Ratnapalan S. Management of infantile colic: a review. Clin Pediatr (Phila). Jan 2009;48(1):14-7. [Medline].
Canivet CA, Ostergren PO, Jakobsson IL, Dejin-Karlsson E, Hagander BM. Infantile colic, maternal smoking and infant feeding at 5 weeks of age. Scand J Public Health. May 2008;36(3):284-91. [Medline].
Heine RG. Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Curr Opin Allergy Clin Immunol. Jun 2006;6(3):220-5. [Medline].
Taubman B. Parental counseling compared with elimination of cow's milk or soy milk protein for the treatment of infant colic syndrome: a randomized trial. Pediatrics. Jun 1988;81(6):756-61. [Medline].
Sondergaard C, Skajaa E, Henriksen T B. Fetal Growth and Infantile Colic. Arch Dis Child Fetal Neonatal Ed. 2000;83:F44-F47.
[Best Evidence] Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. Jan 2007;119(1):e124-30. [Medline].
Savino F, Cresi F, Pautasso S, et al. Intestinal microflora in breastfed colicky and non-colicky infants. Acta Paediatr. Jun 2004;93(6):825-9. [Medline].
Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics. Sep 2010;126(3):e526-33. [Medline].
Akcam M, Yilmaz A. Oral hypertonic glucose solution in the treatment of infantile colic. Pediatr Int. Apr 2006;48(2):125-7. [Medline].
Olafsdottir E, Forshei S, Fluge G, Markestad T. Randomised controlled trial of infantile colic treated with chiropractic spinal manipulation. Arch Dis Child. Feb 2001;84(2):138-41. [Medline].
Wiberg JM, Nordsteen J, Nilsson N. The short-term effect of spinal manipulation in the treatment of infantile colic: a randomized controlled clinical trial with a blinded observer. J Manipulative Physiol Ther. Oct 1999;22(8):517-22. [Medline].
Perry R, Hunt K, Ernst E. Nutritional supplements and other complementary medicines for infantile colic: a systematic review. Pediatrics. Apr 2011;127(4):720-33. [Medline].
Balon AJ. Management of infantile colic. Am Fam Physician. Jan 1997;55(1):235-42, 245-6. [Medline].
Barr RG. The 'Colic' enigma: Prolonged episodes of a normal predisposition to cry. Infant Mental Health Journal. 11:340.
Bergeson PS. Herbal teas for infantile colic. J Pediatr. Oct 1993;123(4):670; author reply 670-1. [Medline].
Berkowitz D, Naveh Y, Berant M. "Infantile colic" as the sole manifestation of gastroesophageal reflux. J Pediatr Gastroenterol Nutr. Feb 1997;24(2):231-3. [Medline].
Forsyth BW, McCarthy PL, Leventhal JM. Problems of early infancy, formula changes, and mothers' beliefs about their infants. J Pediatr. Jun 1985;106(6):1012-7. [Medline].
Frodi A. When Empathy Fails: Aversive Infant Crying and Child Abuse. New York, NY: Plenum Publishers; 1985:263.
[Best Evidence] Hill DJ, Roy N, Heine RG, et al. Effect of a low-allergen maternal diet on colic among breastfed infants: a randomized, controlled trial. Pediatrics. Nov 2005;116(5):e709-15. [Medline].
Kurtoglu S, Uzum K, Hallac IK. 5-Hydoxy-3-indole acetic acid levels in infantile colic:Is serotoninergic tonus responsible for this problem?. Acta paediatrica. 1997;86:764-765. [Medline].
Loethe L, Lindberg T, Jakobsson I. Macromolecular Absorption in Infants with Infantile Colic. Acta Paediatr Scand. 1990;79:417-21. [Medline].
Lucassen PL, Assendelft WJ, Gubbels JW. Effectiveness of treatments for infantile colic: systematic review. BMJ. May 23 1998;316(7144):1563-9. [Medline].
Miller AR, Barr RG. Infantile colic. Is it a gut issue?. Pediatr Clin North Am. Dec 1991;38(6):1407-23. [Medline].
[Guideline] National Collaborating Centre for Primary Care. Postnatal care. Routine postnatal care of women and their babies. London (England): Royal College of General Practitioners; 2006 Jul. [Full Text].
O'Donovan JC, Bradstock AS Jr. The failure of conventional drug therapy in the management of infantile colic. Am J Dis Child. Oct 1979;133(10):999-1001. [Medline].
Pinyerd BJ. Strategies for consoling the infant with colic: fact or fiction?. J Pediatr Nurs. Dec 1992;7(6):403-11. [Medline].
Raiha H, Lehtonen L, Korhonen T. Family life 1 year after infantile colic. Arch Pediatr Adolesc Med. Oct 1996;150(10):1032-6. [Medline].
Rao MR, Brenner RA, Schisterman EF, Vik T, Mills JL. Long term cognitive development in children with prolonged crying. Arch Dis Child. Nov 2004;89(11):989-92. [Medline].
Ruiz-Contreras J, Urquia L, Bastero R. Persistent crying as predominant manifestation of sepsis in infants and newborns. Pediatr Emerg Care. Apr 1999;15(2):113-5. [Medline].
Savino F, Castagno E, Bretto R. A prospective 10-yaer study on children who had severe infantile colic. Acta Paediatrica. 2005;94 ( S 449):129-132. [Medline].
Shenassa E D, Brown Mary-Jean. Maternal Smoking and Infantile Gastrointestinal Dysregulation:The Case of Colic. Pediatr. 2004;114(4):e497-e505.
St James-Roberts I. What is distinct about infants' "colic" cries?. Arch Dis Child. Jan 1999;80(1):56-61; discussion 62. [Medline].
Weissbluth M. Colic. In: Gellis and Kagan's current pediatric therapy. 14th ed. Philadelphia, Pa: WB Saunders.
Weizman Z, Alkrinawi S, Goldfarb D. Efficacy of herbal tea preparation in infantile colic. J Pediatr. Apr 1993;122(4):650-2. [Medline].

