Pediatric Rectal Prolapse Workup
- Author: Jaime Shalkow, MD; Chief Editor: Carmen Cuffari, MD more...
Approach Considerations
The primary care physician should initially approach rectal prolapse as a symptom rather than a specific disease entity and should always search for an underlying disorder. Anatomic causes, such as Hirschsprung disease and previous imperforate anus, should be ruled out. Constipation, diarrhea, parasitic infections, polyps, and anal stenosis.
In particular, cystic fibrosis is an important cause of rectal prolapse in children and should be considered in certain patients who present with rectal prolapse. Clinical clues to cystic fibrosis include oily, malodorous, or floating stool; poor growth pattern; wheezing or other respiratory symptoms; and the presence of digital clubbing. The absence of respiratory symptoms and normal findings upon physical examination do not exclude this possibility. Results of sweat chloride testing and genetic testing confirm the diagnosis.
Over the past decade, there have been considerable advances in several imaging techniques. High-resolution ultrasonography and magnetic resonance imaging (MRI) not only provide superior depiction of the pelvic anatomy but also help to illustrate pathology and document functional changes. Barium enema, proctosigmoidoscopy, video defecography, anal manometry, electromyography, and anal endosonography may be useful.
Internal rectal prolapse (IRP) refers to a full-thickness intussusception of the rectum during defecation. Radiographically, different grades have been proposed, from low-grade (recto-rectal intussusception) to high-grade (rectoanal intussusception) rectal prolapse. This kind of prolapse may lead to outlet obstruction and/or fecal incontinence. IRP plays an important role in the pathophysiology of obstructive defecation (OD), which refers to the inability to empty the rectum satisfactorily during defecation, and is more specifically defined in the Rome III criteria.
For decades, there has been debate about the clinical significance of IRP. However, there appears to be a renewed interest in the clinical relevance and treatment of IRP. The long-disputed progression into external rectal prolapse (ERP) has been made more plausible by data published by Wijffels et al.[30] on the natural history of IRP. Moreover, various other publications on new surgical techniques have shown improved functional outcome after prolapse correction compared with historical surgical series. Patient selection remains critical.
Surgical correction for IRP is possible via a transabdominal or transanal approach. Currently, the most commonly performed procedures are laparoscopic ventral rectopexy (LVR) and stapled transanal rectal resection (STARR). LVR corrects the intussusception of the rectum and reinforces the rectovaginal septum with mesh, which suspends the rectum and vaginal vault to the sacral promontory. During the STARR procedure, a stapled resection of the redundant rectal wall is performed. Most recent publications on IRP and OD are divided between proponents of these 2 techniques. There are, however, no comparative studies, making it difficult to select the optimal treatment for each individual patient.[31]
Laboratory Tests
Sweat chloride test
Because of the potentially disastrous consequences of missing the diagnosis of cystic fibrosis and because of the improved prognosis associated with early diagnosis and institution of treatment, the sweat chloride test is indicated in all patients who present without an underlying anatomic abnormality.
Although cystic fibrosis is not a likely diagnosis in patients who present with rectal prolapse, the estimated incidence of rectal prolapse in patients with cystic fibrosis ranges from 11-23% (20% in patients with cystic fibrosis who are aged 6 months to 3 years). Accordingly, cystic fibrosis should be ruled out in patients who present with rectal prolapse, even if no other signs of the disease are present.
Stool evaluation for ova and parasites
Rectal prolapse has been associated with Escherichia coli 0157:H7; antibiotic-associated colitis; Entamoeba histolytica; and Giardia, Salmonella, Shigella, and Trichuris species. Consider workup for other associated illnesses in the appropriate setting as clinically indicated.
Magnetic Resonance Imaging
MRI can be used both for a multicompartmental dynamic assessment of the pelvic floor—referred to as dynamic MRI defecography—and for the anatomic analysis of the internal anal sphincter (IAS) and the external anal sphincter (EAS)—referred to as static MRI. The enormous potential of MRI in this setting underscores the importance of the radiologist as part of the multidisciplinary team, a part that is needed for an integrated evaluation of pelvic floor disorders.[32]
Barium Enema
Sigmoid intussusception rarely presents as rectal prolapse in pediatric patients. In 1990, Ashcraft et al highlighted the importance of preoperative diagnosis for prevention of inappropriate initial treatment and postoperative recurrence.[33] In their series of 46 patients, 2 required subsequent sigmoid resection. Preoperative barium enema with a defecating view revealed a coiled-spring appearance typical of sigmoid intussusception.
A contrast enema study may be needed to look for polyps or other leading points.
Video Defecography
Video defecography (ie, videofluoroscopy of the barium-filled rectum during defecation) can be used to identify rectal prolapse or intussusception. This study can demonstrate prolapse through the anus, but it is unnecessary for full-thickness rectal prolapse. The anorectal angle is often obtuse in patients with rectal prolapse, especially in those with coexisting fecal incontinence.[34]
Proctosigmoidoscopy
Children with symptoms that suggest rectal polyps should undergo proctosigmoidoscopy to confirm the diagnosis, to obtain biopsy samples when applicable, and to rule out a leading point in the case of intussusception.
Patients with recurring rectal prolapse with no apparent cause or a history of rectal bleeding should undergo proctosigmoidoscopy to rule out polyps.
Other Tests
Anal manometry
The clinical and cost benefits of routine preoperative anal manometry, pudendal nerve motor latency, colonic transit, and defecography are unclear. Anal manometry shows low resting pressure; patients with coexisting fecal incontinence also have low squeezing pressures. However, after surgery, the resting pressure or sphincter length may not change or improve. Squeeze pressure may improve.[34]
Electromyography
Electromyography has provided insights into the pathogenesis of fecal incontinence; however, it has no place in the clinical workup for this entity, and hardly any research has been done so far. Abnormalities can be found in patients with a rectal prolapse, but these results do not predict continence after rectopexy.[34]
Anal endosonography
Anal endosonography may show asymmetry and thickening of the internal anal sphincter and submucosa. Demonstration of a sphincter defect might be useful if a sphincter reconstruction is being considered.[34]
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