Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

Pediatric Short Bowel Syndrome

  • Author: Carmen Cuffari, MD; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
 
Updated: Jul 08, 2016
 

Practice Essentials

Short bowel syndrome (SBS) results from the alteration of intestinal digestion and absorption that occurs after extensive bowel resection. It is a complex disorder with nutritional, metabolic, and infectious consequences. Bowel obstruction is a potential complication of SBS (see the image below).

Small-bowel obstruction caused by intussusception Small-bowel obstruction caused by intussusception in a 5-month-old patient is visible on plain radiograph.

Signs and symptoms

Although SBS may rarely be a congenital condition, most patients with SBS have undergone bowel resection for one of the following:

  • A congenital anomaly such as an omphalocele, gastroschisis, or intestinal atresia
  • Necrotizing enterocolitis associated with prematurity[1]
  • Intestinal ischemia from malrotation and volvulus
  • Crohn disease (infrequent with current treatment)

Children with cloacal exstrophy do not have SBS in the classical sense but often have all the signs and symptoms associated with functional intestinal failure.

Patients with SBS may present with any of the following:

  • Nutritional deficiencies
  • Malabsorptive diarrhea
  • Dehydration
  • Vomiting
  • Bloating
  • Gastroesophageal reflux
  • Failure to thrive
  • Drug toxicities
  • Sepsis

See Clinical Presentation for more detail.

Diagnosis

Children with SBS should undergo standard hematologic and biochemical studies, according to institutional guidelines. Studies may include the following:

  • Electrolytes, BUN, creatinine, calcium, magnesium, phosphorous - Biweekly in both the initial phase and the late period or at the time of presentation for instability
  • Comprehensive metabolic panel, CBC, triglycerides, cholesterol - Weekly in both the initial phase and the late period or at the time of presentation for instability
  • Folate, vitamin B-12, vitamin E, copper, zinc, selenium - Monthly in both the initial phase and the late period or at the time of presentation for instability

Carnitine

The workup for suspected sepsis in patients with SBS may include the following:

  • Blood cultures from both the central and peripheral sites
  • Urinalysis and blood culture specifically to search for fungal infection
  • Abdominal ultrasonography to search for fungal balls in the kidney (only in the case of persistent fungal infection)
  • CT scanning of the abdomen to identify persistent sepsis
  • Ultrasonography of Broviac tip

The workup for suspected bowel obstruction in patients with SBS may include the following:

  • Plain radiography of the abdomen
  • Barium imaging of the bowel

Laboratory procedures may include the following:

  • Upper endoscopy to assess for peptic ulcer disease and possible signs of liver disease (eg, esophageal varices, hypertensive gastropathy)
  • Liver biopsy to evaluate for total parenteral nutrition (TPN)-related liver disease (rarely performed unless the presentation is unusual)

See Workup for more detail.

Management

The management of SBS requires an aggressive multidisciplinary approach that is most often tailored to the individual needs of the patient.[2] Features of treatment include the following:

  • The institution of early and aggressive enteral therapy is the most important stimulus for intestinal adaptation and the eventual discontinuation of parenteral therapy
  • Aggressive resuscitation with fluids, parenteral nutrition, or both is often required in the first week after intestinal resection
  • Serum electrolytes and a comprehensive biochemical panel should be monitored daily In the early postoperative period and on a biweekly or triweekly basis once the values have stabilized
  • The hypersecretion noted within the first 12 months postresection is usually treated with H2 blockers or proton pump inhibitors
  • Parenteral fluid replacement needs may be ongoing, depending on the amount of stool or ostomy output
  • Bacterial overgrowth in the proximal small bowel may require antibiotic therapy, including metronidazole alternating with either kanamycin or oral gentamicin
  • Cholestyramine has been used to bind bile salts in patients with choleretic diarrhea
  • A diverting ileostomy can be used to prevent the stagnation of stool in patients with significant dysmotility
  • Small-bowel transplantation is used only if absolutely necessary in patients with associated severe advanced liver disease and those with major vascular access problems
  • Isolated orthotopic liver transplantation without small-bowel transplantation has been demonstrated to be effective

See Treatment and Medication for more detail.

Next

Background

Few conditions in pediatric gastroenterology pose as great a challenge as short bowel syndrome (SBS).[3] Short bowel syndrome is the result of the alteration of intestinal digestion and absorption that occurs following extensive bowel resection. It represents a complex disorder that affects normal intestinal physiology with nutritional, metabolic, and infectious consequences.

Previous
Next

Pathophysiology

The small intestine of the neonate is approximately 250 cm in length. By adulthood, the small intestine grows to approximately 750 cm. As a consequence, the infant and the young child have a favorable long-term prognosis compared to an adult in regards to potential intestinal growth after intestinal resection. Intestinal adaptation may take weeks to months to be achieved; in the interim, children who have had intestinal resection need nutritional support through various therapeutic measures, including parenteral nutrition. The duodenum and jejunum are responsible for the absorption of most dietary constituents except vitamin B-12 and bile acids.

The jejunum is characterized by long villi and a large absorptive area. The tight junctions are relatively large, rendering the epithelium more porous to larger molecules and the free and rapid flux of water and electrolytes. In comparison, the ileum has shorter villi and a less absorptive surface area than the jejunum. Furthermore, the tight junctions are tighter, permitting less flux of water and electrolytes from the vascular space into the intestinal lumen, and, consequently, the ileum is more efficient in the absorption of water. Although nutrients are less well absorbed in the ileum, it has site-specific receptors for the absorption of bile acids and vitamin B12. Moreover, many GI hormones that affect intestinal motility, including enteroglucagon and peptide YY, are produced in the ileum. The small intestinal sites of nutrient absorption are as follows:

  • Duodenum - Iron
  • Jejunum - Carbohydrates, proteins, fat, vitamins
  • Ileum - Bile acids, vitamin B-12

In general, virtually all digestion and absorption is completed within the first 100-150 cm of jejunum in a healthy individual. In the absence of an intact colon, the minimum length of healthy bowel necessary to avoid parenteral nutrition is approximately 100 cm. Patients who have less than 100 cm of jejunum exhibit significant malabsorption. Although the ileum is limited in its capacity to form chylomicrons compared to the jejunum, studies have shown that the ileum has greater adaptive function as far as improving its absorptive function in the presence of short bowel syndrome. Similarly, studies in animals have shown that intestinal transit time is more likely to improve (ie, increase) in patients with proximal small-bowel resection as opposed to patients with distal small-bowel resection.

The jejunum cannot develop site-specific carriers for the transportation of vitamin B12 and bile salts, and, consequently, these are malabsorbed permanently in patients, following ileal resection. Furthermore, the loss of enteroglucagon and peptide YY cannot be underscored in the regulation of small-bowel motility.

Previous
Next

Epidemiology

Mortality/Morbidity

The leading causes of death in infants with short bowel syndrome who are being treated with parenteral nutrition are central line sepsis and liver failure with the prolonged use of parenteral nutrition.

Previous
 
 
Contributor Information and Disclosures
Author

Carmen Cuffari, MD Associate Professor, Department of Pediatrics, Division of Gastroenterology/Nutrition, Johns Hopkins University School of Medicine

Carmen Cuffari, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Royal College of Physicians and Surgeons of Canada

Disclosure: Received honoraria from Prometheus Laboratories for speaking and teaching; Received honoraria from Abbott Nutritionals for speaking and teaching.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

David A Piccoli, MD Chief of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia; Professor, University of Pennsylvania School of Medicine

David A Piccoli, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American Gastroenterological Association, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

Disclosure: Nothing to disclose.

Chief Editor

Jatinder Bhatia, MBBS, FAAP Professor of Pediatrics, Medical College of Georgia, Georgia Regents University; Chief, Division of Neonatology, Director, Fellowship Program in Neonatal-Perinatal Medicine, Director, Transport/ECMO/Nutrition, Vice Chair, Clinical Research, Department of Pediatrics, Children's Hospital of Georgia

Jatinder Bhatia, MBBS, FAAP is a member of the following medical societies: American Academy of Pediatrics, American Association for the Advancement of Science, American Pediatric Society, American Society for Nutrition, American Society for Parenteral and Enteral Nutrition, Academy of Nutrition and Dietetics, Society for Pediatric Research, Southern Society for Pediatric Research

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Gerber.

Additional Contributors

Jorge H Vargas, MD Professor of Pediatrics and Clinical Professor of Pediatric Gastroenterology, University of California, Los Angeles, David Geffen School of Medicine; Consulting Physician, Department of Pediatrics, University of California at Los Angeles Health System

Jorge H Vargas, MD is a member of the following medical societies: American Liver Foundation, Latin American Society of Pediatric Gastroenterology, Hepatology & Nutrition, American Society for Gastrointestinal Endoscopy, American Society for Parenteral and Enteral Nutrition, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

Disclosure: Nothing to disclose.

References
  1. Cole CR, Hansen NI, Higgins RD, Ziegler TR, Stoll BJ. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months. Pediatrics. 2008 Sep. 122(3):e573-82. [Medline]. [Full Text].

  2. Weih S, Kessler M, Fonouni H, Golriz M, Hafezi M, Mehrabi A, et al. Current practice and future perspectives in the treatment of short bowel syndrome in children-a systematic review. Langenbecks Arch Surg. 2011 Nov 22. [Medline].

  3. Goday PS. Short bowel syndrome: how short is too short?. Clin Perinatol. 2009 Mar. 36(1):101-10. [Medline].

  4. Seres D, Sacks GS, Pedersen CA, et al. Parenteral nutrition safe practices: results of the 2003 American Society for Parenteral and Enteral Nutrition survey. JPEN J Parenter Enteral Nutr. 2006 May-Jun. 30(3):259-65. [Medline].

  5. Goulet OJ, Revillon Y, Jan D, et al. Neonatal short bowel syndrome. J Pediatr. 1991 Jul. 119(1 ( Pt 1)):18-23. [Medline].

  6. Novak B. Long-term teduglutide frees some short bowel patients from parenteral support. Medscape Medical News. January 27, 2014. [Full Text].

  7. Jeppesen PB. Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome. Therap Adv Gastroenterol. 2012 May. 5(3):159-71. [Medline].

  8. Jeppesen PB, Staun M, Tjellesen L, Mortensen PB. Effect of intravenous ranitidine and omeprazole on intestinal absorption of water, sodium, and macronutrients in patients with intestinal resection. Gut. 1998 Dec. 43(6):763-9. [Medline].

  9. Guo M, Li Y, Li J. Role of Growth Hormone, Glutamine and Enteral Nutrition in Pediatric Short Bowel Syndrome: A Pilot Follow-Up Study. Eur J Pediatr Surg. 2011 Dec 7. [Medline].

  10. Greenberg RG, Moran C, Ulshen M, Smith PB, Benjamin DK Jr, Cohen-Wolkowiez M. Outcomes of catheter-associated infections in pediatric patients with short bowel syndrome. J Pediatr Gastroenterol Nutr. 2010 Apr. 50(4):460-2. [Medline]. [Full Text].

  11. Chung PH, Wong KK, Wong RM, Tsoi NS, Chan KL, Tam PK. Clinical experience in managing pediatric patients with ultra-short bowel syndrome using omega-3 fatty acid. Eur J Pediatr Surg. 2010 Mar. 20(2):139-42. [Medline].

  12. Park KT, Nespor C, Kerner J Jr. The use of Omegaven in treating parenteral nutrition-associated liver disease. J Perinatol. 2011 Apr. 31 Suppl 1:S57-60. [Medline].

  13. Ascher DP, Shoupe BA, Maybee D, Fischer GW. Persistent catheter-related bacteremia: clearance with antibiotics and urokinase. J Pediatr Surg. 1993 Apr. 28(4):627-9. [Medline].

  14. Bernard DK, Shaw MJ. Principles of nutrition therapy for short-bowel syndrome. Nutr Clin Pract. 1993 Aug. 8(4):153-62. [Medline].

  15. Bloom SR. Gut hormones in adaptation. Gut. 1987. 28 Suppl:31-5. [Medline].

  16. Buchman AL. The clinical management of short bowel syndrome: steps to avoid parenteral nutrition. Nutrition. 1997 Oct. 13(10):907-13. [Medline].

  17. Byrne TA, Persinger RL, Young LS, et al. A new treatment for patients with short-bowel syndrome. Growth hormone, glutamine, and a modified diet. Ann Surg. 1995 Sep. 222(3):243-54; discussion 254-5. [Medline].

  18. Capron JP, Gineston JL, Herve MA, Braillon A. Metronidazole in prevention of cholestasis associated with total parenteral nutrition. Lancet. 1983 Feb 26. 1(8322):446-7. [Medline].

  19. Cole CR, Ziegler TR. Small bowel bacterial overgrowth: a negative factor in gut adaptation in pediatric SBS. Curr Gastroenterol Rep. 2007 Dec. 9(6):456-62. [Medline].

  20. Cosnes L, Carbonnel F, Beaugerie L. Functional adaptation after extensive small bowel resection in humans. Eur J Gastroenterol Hepatol. 1994. 6:197.

  21. Cummings JH. Colonic absorption: the importance of short chain fatty acids in man. Scand J Gastroenterol Suppl. 1984. 93:89-99. [Medline].

  22. Dudrick SJ, Latifi R, Fosnocht DE. Management of the short-bowel syndrome. Surg Clin North Am. 1991 Jun. 71(3):625-43. [Medline].

  23. Fine H, Levine GM, Shiau YF. Effects of cholecystokinin and secretin on intestinal structure and function. Am J Physiol. 1983 Sep. 245(3):G358-63. [Medline].

  24. Fordtran JS, Dietschy JM. Water and electrolyte movement in the intestine. Gastroenterology. 1966 Feb. 50(2):263-85. [Medline].

  25. Gazet JC, Kopp J. The surgical significance of the ileocecal junction. Surgery. 1964. 56:565-73.

  26. Grant D. Current results of intestinal transplantation. The International Intestinal Transplant Registry. Lancet. 1996 Jun 29. 347(9018):1801-3. [Medline].

  27. Grosfeld JL, Rescorla FJ, West KW. Short bowel syndrome in infancy and childhood. Analysis of survival in 60 patients. Am J Surg. 1986 Jan. 151(1):41-6. [Medline].

  28. Hays TL, Saavedra JM, Mattis LE. The use of high-fat low-carbohydrate diets for advancement of enteral feedings in children with short bowel syndrome. Top Clin Nutr. 1995. 10(4):35-41.

  29. Hofmann AF, Poley JR. Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride. Gastroenterology. 1972 May. 62(5):918-34. [Medline].

  30. Hwang TL, O'Dwyer ST, Smith RJ. Preservation of small bowel mucosa using glutamine enriched parenteral nutrition. Surg Forum. 1986. 37:56-8.

  31. Hylander E, Ladefoged K, Jarnum S. Calcium absorption after intestinal resection. The importance of a preserved colon. Scand J Gastroenterol. 1990 Jul. 25(7):705-10. [Medline].

  32. Hyman PE, Everett SL, Harada T. Gastric acid hypersecretion in short bowel syndrome in infants: association with extent of resection and enteral feeding. J Pediatr Gastroenterol Nutr. 1986 Mar-Apr. 5(2):191-7. [Medline].

  33. Infantino BJ, Mercer DF, Hobson BD, Fischer RT, Gerhardt BK, Grant WJ, et al. Successful Rehabilitation in Pediatric Ultrashort Small Bowel Syndrome. J Pediatr. 2013 Jul 15. [Medline].

  34. Jeejeebhoy KN. Therapy of the short-gut syndrome. Lancet. 1983 Jun 25. 1(8339):1427-30. [Medline].

  35. Klish WJ, Putnam TC. The short gut. Am J Dis Child. 1981 Nov. 135(11):1056-61. [Medline].

  36. Langnas AN, Shaw BW Jr, Antonson DL, et al. Preliminary experience with intestinal transplantation in infants and children. Pediatrics. 1996 Apr. 97(4):443-8. [Medline].

  37. Levine GM, Deren JJ, Yezdimir E. Small-bowel resection. Oral intake is the stimulus for hyperplasia. Am J Dig Dis. 1976 Jul. 21(7):542-6. [Medline].

  38. Lowry SF, Brennan MF. Abnormal liver function during parenteral nutrition: Relation to infusion excess. J Surg Res. 1979. 26:300-7.

  39. Marotta RB, Floch MH. Dietary therapy of steatorrhea. Gastroenterol Clin North Am. 1989 Sep. 18(3):485-512. [Medline].

  40. Messing B, Pigot F, Rongier M, et al. Intestinal absorption of free oral hyperalimentation in the very short bowel syndrome. Gastroenterology. 1991 Jun. 100(6):1502-8. [Medline].

  41. Nightingale JM, Kamm MA, van der Sijp JR, et al. Disturbed gastric emptying in the short bowel syndrome. Evidence for a 'colonic brake'. Gut. 1993 Sep. 34(9):1171-6. [Medline].

  42. Nordgaard I, Hansen BS, Mortensen PB. Importance of colonic support for energy absorption as small-bowel failure proceeds. Am J Clin Nutr. 1996 Aug. 64(2):222-31. [Medline].

  43. Parker P, Stroop S, Greene H. A controlled comparison of continuous versus intermittent feeding in the treatment of infants with intestinal disease. J Pediatr. 1981 Sep. 99(3):360-4. [Medline].

  44. Purdum PP 3d, Kirby DF. Short-bowel syndrome: a review of the role of nutrition support. JPEN J Parenter Enteral Nutr. 1991 Jan-Feb. 15(1):93-101. [Medline].

  45. Reyes J, Todo S, Bueno J, et al. Intestinal transplantation in children: five-year experience. Transplant Proc. 1996 Oct. 28(5):2755-6. [Medline].

  46. Scolapio JS, Camilleri M, Fleming CR, et al. Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study. Gastroenterology. 1997 Oct. 113(4):1074-81. [Medline].

  47. Sheldon GF, Peterson SR, Sanders R. Hepatic dysfunction during hyperalimentation. Arch Surg. 1978 Apr. 113(4):504-8. [Medline].

  48. Sial S, Koussayer T, Klein S. Nutritional management of a patient with short-bowel syndrome and large-volume jejunostomy output. Nutrition. 1994 Jan-Feb. 10(1):37-40; discussion 40-1. [Medline].

  49. Spagnuolo MI, Iorio R, Vegnente A, Guarino A. Ursodeoxycholic acid for treatment of cholestasis in children on long-term total parenteral nutrition: a pilot study. Gastroenterology. 1996 Sep. 111(3):716-9. [Medline].

  50. Thompson JS. Surgical management of short bowel syndrome. Surgery. 1993 Jan. 113(1):4-7. [Medline].

  51. Thompson JS, Rikkers LF. Surgical alternatives for the short bowel syndrome. Am J Gastroenterol. 1987 Feb. 82(2):97-106. [Medline].

  52. Todo S, Tzakis AG, Abu-Elmagd K, et al. Cadaveric small bowel and small bowel-liver transplantation in humans. Transplantation. 1992 Feb. 53(2):369-76. [Medline].

  53. Treem WR. Short bowel syndrome. Wyllie R, Hyams JS, eds. Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management. Philadelphia, PA: WB Saunders; 1993. 573-603.

  54. Vileisis RA, Inwood RJ, Hunt CE. Prospective controlled study of parenteral nutrition-associated cholestatic jaundice: effect of protein intake. J Pediatr. 1980 May. 96(5):893-7. [Medline].

  55. Woolf GM, Miller C, Kurian R, Jeejeebhoy KN. Diet for patients with a short bowel: high fat or high carbohydrate?. Gastroenterology. 1983 Apr. 84(4):823-8. [Medline].

  56. Zahavi I, Shaffer EA, Gall DG. Total parenteral nutrition-associated cholestasis: acute studies in infant and adult rabbits. J Pediatr Gastroenterol Nutr. 1985 Aug. 4(4):622-7. [Medline].

  57. Zurier RB, Campbell RG, Hashim SA, Van Itallie TB. Use of medium-chain triglyceride in management of patients with massive resection of the small intestine. N Engl J Med. 1966 Mar 3. 274(9):490-3. [Medline].

Previous
Next
 
Small-bowel obstruction caused by intussusception in a 5-month-old patient is visible on plain radiograph.
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.