Soy Protein Intolerance Treatment & Management

  • Author: Stefano Guandalini, MD; Chief Editor: Carmen Cuffari, MD   more...
 
Updated: Aug 3, 2011
 

Medical Care

Children affected by soy protein intolerance respond quickly to elimination of soy formula and introduction of a hydrolyzed protein formula.

Numerous therapeutic strategies have become to be invetigated targeting foods that most frequently provoke severe IgE-mediated anaphylactic reactions (peanut, tree nuts, and shellfish) or are most common in children, such as cow's milk, soy, and egg. Approaches being pursued are both food allergen–specific and nonspecific. The former include oral, sublingual, and epicutaneous immunotherapy (desensitization).[21]

Proceed to Medication
 
 
Contributor Information and Disclosures
Author

Stefano Guandalini, MD  Director, University of Chicago Celiac Disease Program, Section Chief of Gastroenterology, Hepatology and Nutrition; Professor, Department of Pediatrics, University of Chicago Comer Children's Hospital

Stefano Guandalini, MD is a member of the following medical societies: American Gastroenterological Association, European Society for Paediatric Gastroenterology, Hepatology & Nutrition, and North American Society for Pediatric Gastroenterology and Nutrition

Disclosure: Nothing to disclose.

Coauthor(s)

Agostino Nocerino, MD, PhD  Chief of Pediatric Oncology, Department of Pediatrics, University of Udine, Italy

Agostino Nocerino, MD, PhD is a member of the following medical societies: American Society of Pediatric Hematology/Oncology

Disclosure: Nothing to disclose.

Specialty Editor Board

Jorge H Vargas, MD  Professor of Pediatrics and Clinical Professor of Pediatric Gastroenterology, University of California, Los Angeles, David Geffen School of Medicine; Consulting Physician, Department of Pediatrics, University of California at Los Angeles Health System

Jorge H Vargas, MD is a member of the following medical societies: American Liver Foundation, American Society for Gastrointestinal Endoscopy, American Society for Parenteral and Enteral Nutrition, Latin American Society of Pediatric Gastroenterology, Hepatology & Nutrition, and North American Society for Pediatric Gastroenterology and Nutrition

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

David A Piccoli, MD  Chief of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia; Professor, University of Pennsylvania School of Medicine

David A Piccoli, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American Gastroenterological Association, and North American Society for Pediatric Gastroenterology and Nutrition

Disclosure: Nothing to disclose.

Steven M Schwarz, MD, FAAP, FACN, AGAF  Professor of Pediatrics, Children's Hospital at Downstate, State University of New York Downstate Medical Center

Steven M Schwarz, MD, FAAP, FACN, AGAF is a member of the following medical societies: American Academy of Pediatrics, American College of Nutrition, American College of Physician Executives, American Gastroenterological Association, American Pediatric Society, Gastroenterology Research Group, New York Academy of Medicine, North American Society for Pediatric Gastroenterology and Nutrition, and Society for Pediatric Research

Disclosure: Curemark, LLC Consulting fee Board membership; Centocor, Inc. Grant/research funds Independent contractor; Johnson & Johnson, Inc. Grant/research funds Independent contractor

Chief Editor

Carmen Cuffari, MD  Associate Professor, Department of Pediatrics, Division of Gastroenterology/Nutrition, Johns Hopkins University School of Medicine

Carmen Cuffari, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, and Royal College of Physicians and Surgeons of Canada

Disclosure: Nothing to disclose.

References
  1. [Guideline] American Academy of Pediatrics Committee on Nutrition. Soy protein-based formulas: recommendations for use in infant feeding. Pediatrics. Jan 1998;101(1 Pt 1):148-53. [Medline].

  2. ESPGHAN Committee on Nutrition. Soy Protein Infant Formulae and Follow-On Formulae: A Commentary by the ESPGHAN Committee on Nutrition. J. Ped. Gastroenterol. Nutr. Apr 2006;42 (4):352-361. [Medline]. [Full Text].

  3. [Best Evidence] Osborn DA, Sinn J. Soy formula for prevention of allergy and food intolerance in infants. Cochrane Database Syst Rev. 2006;(4):CD003741. [Medline].

  4. Giampietro PG, Ragno V, Daniele S. Soy hypersensitivity in children with food allergy. Ann Allergy. Aug 1992;69(2):143-6. [Medline].

  5. Johnstone DE, Roghmann KJ. Recommendations for soy infant formula: a review of the literature and a survey of pediatric allergists. Pediatr Asthma Allergy Immunol. 1993;7:77-88.

  6. Halpern SR, Sellars WA, Johnson RB, Anderson RB, Saperstein S, Reisch JS. Development of childhood allergy in infants fed breast, soy, or cow milk. Allergy Clin Immunol. 1973;51:139-151.

  7. Bruno G, Giampietro PG, Del Guercio MJ. Soy allergy is not common in atopic children: a multicenter study. Pediatr Allergy Immunol. Nov 1997;8(4):190-3. [Medline].

  8. Sampson HA. Jerome Glaser lectureship. The role of food allergy and mediator release in atopic dermatitis. J Allergy Clin Immunol. Apr 1988;81(4):635-45. [Medline].

  9. Zeiger RS, Sampson HA, Bock SA, et al. Soy allergy in infants and children with IgE-associated cow's milk allergy. J Pediatr. May 1999;134(5):614-22. [Medline].

  10. Mehr S, Kakakios A, Frith K, Kemp AS. Food protein-induced enterocolitis syndrome: 16-year experience. Pediatrics. Mar 2009;123(3):e459-64. [Medline].

  11. Zoppi G, Guandalini S. The story of soy formula feeding in infants: a road paved with good intentions. J Pediatr Gastroenterol Nutr. May 1999;28(5):541-3. [Medline].

  12. Iyngkaran N, Yadav M, Looi LM. Effect of soy protein on the small bowel mucosa of young infants recovering from acute gastroenteritis. J Pediatr Gastroenterol Nutr. Jan-Feb 1988;7(1):68-75. [Medline].

  13. Foucard T, Malmheden Yman I. A study on severe food reactions in Sweden--is soy protein an underestimated cause of food anaphylaxis?. Allergy. Mar 1999;54(3):261-5. [Medline].

  14. Ballmer-Weber BK, Holzhauser T, Scibilia J et al. Clinical characteristics of soybean Clinical characteristics of soybean allergy in Europe: A double-blind, placebo-controlled food challenge study. J Allergy Clin Immunol. Jun 2007;119 (6):1489-96. [Medline]. [Full Text].

  15. Katz Y, Goldberg MR, Rajuan N, Cohen A, Leshno M. The prevalence and natural course of food protein-induced enterocolitis syndrome to cow's milk: a large-scale, prospective population-based study. J Allergy Clin Immunol. Mar 2011;127(3):647-53.e1-3. [Medline].

  16. Lucarelli S, Di Nardo G, Lastrucci G, D'Alfonso Y, Marcheggiano A, Federici T, et al. Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation. BMC Gastroenterol. Jul 16 2011;11(1):82. [Medline].

  17. Masilamani K, Jolles S, Huddart S, Tuthill DP. Successful dietary treatment of recurrent intussusception. Arch Dis Child. Mar 2009;94(3):248-9. [Medline].

  18. Syrigou EI, Pitsios C, Panagiotou I, Chouliaras G, Kitsiou S, Kanariou M, et al. Food allergy-related paediatric constipation: the usefulness of atopy patch test. Eur J Pediatr. Feb 25 2011;[Medline].

  19. Duenas-Laita A, Pineda F, Armentia A. Hypersensitivity to generic drugs with soybean oil. N Engl J Med. Sep 24 2009;361(13):1317-8. [Medline].

  20. Savage JH, Kaeding AJ, Matsui EC, Wood RA. The natural history of soy allergy. J Allergy Clin Immunol. Mar 2010;125(3):683-6. [Medline].

  21. Nowak-Wegrzyn A, Sampson HA. Future therapies for food allergies. J Allergy Clin Immunol. Mar 2011;127(3):558-73; quiz 574-5. [Medline]. [Full Text].

  22. Aggett PJ, Haschke F, Heine W. Comment on antigen-reduced infant formulae. ESPGAN Committee on Nutrition. Acta Paediatr. Mar 1993;82(3):314-9. [Medline].

  23. American Academy of Pediatrics: Committee on Nutrition. Hypoallergenic infant formulas. Pediatrics. Aug 2000;106 (2 Pt1):346-9. [Medline]. [Full Text].

  24. Businco L, Bruno G, Giampietro PG. Soy protein for the prevention and treatment of children with cow-milk allergy. Am J Clin Nutr. Dec 1998;68(6 Suppl):1447S-1452S. [Medline].

  25. Businco L, Dreborg S, Einarsson R, et al. Hydrolysed cow's milk formulae. Allergenicity and use in treatment and prevention. An ESPACI position paper. European Society of Pediatric Allergy and Clinical Immunology. Pediatr Allergy Immunol. Aug 1993;4(3):101-11. [Medline].

  26. Eastham EJ, Lichauco T, Pang K, Walker WA. Antigenicity of infant formulas and the induction of systemic immunological tolerance by oral feeding: cow's milk versus soy milk. J Pediatr Gastroenterol Nutr. 1982;1(1):23-8. [Medline].

  27. Franck P, Moneret Vautrin DA, Dousset B, et al. The allergenicity of soybean-based products is modified by food technologies. Int Arch Allergy Immunol. Jul 2002;128(3):212-9. [Medline].

  28. Halpin TC, Byrne WJ, Ament ME. Colitis, persistent diarrhea, and soy protein intolerance. J Pediatr. Sep 1977;91(3):404-7. [Medline].

  29. Herian AM, Bush RK, Taylor SL. Protein and allergen content of commercial skin test extracts for soybeans. Clin Exp Allergy. Apr 1992;22(4):461-8. [Medline].

  30. Perkkio M, Savilahti E, Kuitunen P. Morphometric and immunohistochemical study of jejunal biopsies from children with intestinal soy allergy. Eur J Pediatr. Sep 1981;137(1):63-9. [Medline].

  31. Poley JR, Klein AW. Scanning electron microscopy of soy protein-induced damage of small bowel mucosa in infants. J Pediatr Gastroenterol Nutr. May 1983;2(2):271-87. [Medline].

  32. Setchell KD. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr. Dec 1998;68(6 Suppl):1333S-1346S. [Medline].

  33. Setchell KD, Zimmer-Nechemias L, Cai J. Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet. Jul 5 1997;350(9070):23-7. [Medline].

Previous
Next
 
Typical atopic dermatitis on the face of an infant.
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.