eMedicine Specialties > Pediatrics: General Medicine > Hematology

Anemia, Chronic: Multimedia

Author: Susumu Inoue, MD, Professor of Pediatrics and Human Development, Michigan State University College of Human Medicine; Clinical Professor of Pediatrics, Wayne State University School of Medicine; Director of Pediatric Hematology/Oncology, Associate Director of Pediatric Education, Department of Pediatrics, Hurley Medical Center
Coauthor(s): John T Truman, MD, MPH, Professor of Clinical Pediatrics, Columbia University; Deputy Chair, Department of Pediatrics, Section of Hematology-Oncology, Babies and Children's Hospital of New York; Margaret T Lee, MD, Assistant Professor, Department of Pediatrics, Division of Pediatric Hematology, Children's Hospital of New York, Columbia University
Contributor Information and Disclosures

Updated: Dec 8, 2008

Multimedia

Blood smear from a black male with glucose-6-phos...Media file 1: Blood smear from a black male with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency that resulted in acute hemolysis. Note blister (helmet or bite) cells and very dense spherocytic cells. The blood smear is virtually pathognomic of this disorder.
Blood smear from a black male with glucose-6-phos...

Blood smear from a black male with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency that resulted in acute hemolysis. Note blister (helmet or bite) cells and very dense spherocytic cells. The blood smear is virtually pathognomic of this disorder.

Blood smear of hereditary spherocytosis (HS). Not...Media file 2: Blood smear of hereditary spherocytosis (HS). Note many spherocytic cells. Not all patients with HS are anemic.
Blood smear of hereditary spherocytosis (HS). Not...

Blood smear of hereditary spherocytosis (HS). Note many spherocytic cells. Not all patients with HS are anemic.

Blood smear of hemoglobin C trait. Note numerous ...Media file 3: Blood smear of hemoglobin C trait. Note numerous target cells. Target cells are a characteristic of this hemoglobinopathy. The trait patient has no anemia. Target cells are also seen in patients with iron deficiency anemia, thalassemia, sickle cell disease, and liver disease.
Blood smear of hemoglobin C trait. Note numerous ...

Blood smear of hemoglobin C trait. Note numerous target cells. Target cells are a characteristic of this hemoglobinopathy. The trait patient has no anemia. Target cells are also seen in patients with iron deficiency anemia, thalassemia, sickle cell disease, and liver disease.

Blood smear of a patient with homozygous sickle c...Media file 4: Blood smear of a patient with homozygous sickle cell disease. Note several sickle cells, a nucleated RBC, and a red cell with Howell-Jolly body (indicated by an arrow), evidence of functional asplenia.
Blood smear of a patient with homozygous sickle c...

Blood smear of a patient with homozygous sickle cell disease. Note several sickle cells, a nucleated RBC, and a red cell with Howell-Jolly body (indicated by an arrow), evidence of functional asplenia.

A blood smear showing a few schistocytes. This pa...Media file 5: A blood smear showing a few schistocytes. This patient had Kaposi type hemangioendothelioma with periodic microangiopathic hemolysis and disseminated coagulopathy (Kasabach-Merritt phenomenon).
A blood smear showing a few schistocytes. This pa...

A blood smear showing a few schistocytes. This patient had Kaposi type hemangioendothelioma with periodic microangiopathic hemolysis and disseminated coagulopathy (Kasabach-Merritt phenomenon).

A blood smear of a patient with beta thalassemia ...Media file 6: A blood smear of a patient with beta thalassemia trait. Note red cells pointed by arrows. Multiple bluish dots in the cells are called basophilic stipplings and consist of aggregated ribosomes. They are often present in immature red cells such as reticulocytes.
A blood smear of a patient with beta thalassemia ...

A blood smear of a patient with beta thalassemia trait. Note red cells pointed by arrows. Multiple bluish dots in the cells are called basophilic stipplings and consist of aggregated ribosomes. They are often present in immature red cells such as reticulocytes.

More on Anemia, Chronic

Overview: Anemia, Chronic
Differential Diagnoses & Workup: Anemia, Chronic
Treatment & Medication: Anemia, Chronic
Follow-up: Anemia, Chronic
Multimedia: Anemia, Chronic
References

References

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  2. Guillem F, Lawson S, Kannengiesser C, Westerman M, Beaumont C, Grandchamp B. Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency. Blood. Sep 1 2008;112(5):2089-91. [Medline].

  3. Barth E, Malorgio C, Tamaro P. Allogeneic bone marrow transplantation in hematologic disorders of childhood: new trends and controversies. Haematologica. Nov 2000;85(11 Suppl):2-8. [Medline].

  4. Brill JR, Baumgardner DJ. Normocytic anemia. Am Fam Physician. Nov 15 2000;62(10):2255-64. [Medline].

  5. Carvalho NF, Kenney RD, Carrington PH, Hall DE. Severe nutritional deficiencies in toddlers resulting from health food milk alternatives. Pediatrics. Apr 2001;107(4):E46. [Medline].

  6. Croisille L, Tchernia G, Casadevall N. Autoimmune disorders of erythropoiesis. Curr Opin Hematol. Mar 2001;8(2):68-73. [Medline].

  7. Fitzsimons EJ, Brock JH. The anaemia of chronic disease. BMJ. Apr 7 2001;322(7290):811-2. [Medline].

  8. Giri N, Kang E, Tisdale JF, et al. Clinical and laboratory evidence for a trilineage haematopoietic defect in patients with refractory Diamond-Blackfan anaemia. Br J Haematol. Jan 2000;108(1):167-75. [Medline].

  9. Janka GE, Schneider EM. Modern management of children with haemophagocytic lymphohistiocytosis. Br J Haematol. Jan 2004;124(1):4-14. [Medline].

  10. Novitzky N. Myelodysplastic syndromes in children. A critical review of the clinical manifestations and management. Am J Hematol. Apr 2000;63(4):212-22. [Medline].

  11. Sherry B, Mei Z, Md RY. Continuation of the decline in prevalence of anemia in low-income infants and children in five states. Pediatrics. Apr 2001;107(4):677-82. [Medline].

  12. Yarali N, Duru F, Sipahi T, et al. Parvovirus B19 infection reminiscent of myelodysplastic syndrome in three children with chronic hemolytic anemia. Pediatr Hematol Oncol. Sep 2000;17(6):475-82. [Medline].

Further Reading

Keywords

primary chronic anemia, secondary chronic anemia, iron deficiency, hereditary spherocytosis, HS, sickle cell disease, thalassemia, chronic anemia, anemia, low hemoglobin levels, hemoglobinopathy, osteomyelitis, hookworm, heart failure, syncope, Diamond-Blackfan anemia, cholelithiasis, splenomegaly, constipation, hypothyroidism, chronic pyelonephritis, bacterial endocarditis, osteomyelitis, jaundice, gallstones, Fanconi anemia, thrombocytopenia, collagen vascular disease, hypersplenism, leukemia, myelofibrosis, myeloproliferative disorder, myelodysplastic syndrome, transient erythroblastopenia of childhood, TEC, Hodgkin disease, non-Hodgkin lymphomas, rhabdomyosarcoma, toxoplasmosis, rubella, cytomegalovirus infection, herpes simplex, hemolytic uremic syndrome, HUS, thrombotic thrombocytopenic purpura, TTP, pyruvate kinase deficiency, idiopathic pulmonary hemosiderosis, paroxysmal nocturnal hemoglobinuria, von Willebrand disease

Contributor Information and Disclosures

Author

Susumu Inoue, MD, Professor of Pediatrics and Human Development, Michigan State University College of Human Medicine; Clinical Professor of Pediatrics, Wayne State University School of Medicine; Director of Pediatric Hematology/Oncology, Associate Director of Pediatric Education, Department of Pediatrics, Hurley Medical Center
Susumu Inoue, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Hematology, American Society of Pediatric Hematology/Oncology, International Society for Experimental Hematology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Coauthor(s)

John T Truman, MD, MPH, Professor of Clinical Pediatrics, Columbia University; Deputy Chair, Department of Pediatrics, Section of Hematology-Oncology, Babies and Children's Hospital of New York
John T Truman, MD, MPH is a member of the following medical societies: American Academy of Pediatrics, American Association for the History of Medicine, American Society of Pediatric Nephrology, and New York Academy of Medicine
Disclosure: Nothing to disclose.

Margaret T Lee, MD, Assistant Professor, Department of Pediatrics, Division of Pediatric Hematology, Children's Hospital of New York, Columbia University
Margaret T Lee, MD is a member of the following medical societies: American Society of Hematology
Disclosure: Nothing to disclose.

Medical Editor

J Martin Johnston, MD, Associate Professor of Pediatrics, Mercer University School of Medicine; Director of Pediatric Hematology/Oncology, Backus Children's Hospital; Consulting Oncologist/Hematologist, St Damien's Pediatric Hospital
J Martin Johnston, MD is a member of the following medical societies: American Society of Pediatric Hematology/Oncology
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from broker recommendation; Avanir Pharma Stock Investment from broker recommendation

Managing Editor

Steven K Bergstrom, MD, Assistant to the Chairman, Department of Pediatrics, Division of Hematology-Oncology, Kaiser Permanente Medical Center of Oakland
Steven K Bergstrom, MD is a member of the following medical societies: Alpha Omega Alpha, American Society of Clinical Oncology, American Society of Hematology, American Society of Pediatric Hematology/Oncology, Children's Oncology Group, and International Society for Experimental Hematology
Disclosure: Nothing to disclose.

CME Editor

Samuel Gross, MD, Professor Emeritus, Department of Pediatrics, University of Florida, Clinical Professor, Department of Pediatrics, UNC, Adjunct Professor, Department of Pediatrics, Duke University
Samuel Gross, MD is a member of the following medical societies: American Association for Cancer Research, American Society for Blood and Marrow Transplantation, American Society of Clinical Oncology, American Society of Hematology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Chief Editor

Max J Coppes, MD, PhD, MBA, Executive Director, Center for Cancer and Blood Disorders, Children's National Medical Center; Professor of Medicine, Oncology, and Pediatrics, Georgetown University
Max J Coppes, MD, PhD, MBA is a member of the following medical societies: American Association for Cancer Research, American Society of Pediatric Hematology/Oncology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

 
 
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