eMedicine Specialties > Pediatrics: General Medicine > Hematology

Donath-Landsteiner Hemolytic Anemia: Multimedia

Author: M Monica Gramatges, MD, Fellow in Pediatric Hematology/Oncology, Stanford University
Coauthor(s): Michael R Jeng, MD, Associate Professor, Department of Pediatrics, Division of Hematology/Oncology, Stanford University School of Medicine
Contributor Information and Disclosures

Updated: May 19, 2009

Multimedia

Blood smear showing spherocytosis, polychromatoph...Media file 1: Blood smear showing spherocytosis, polychromatophilia, and erythrophagocytosis by neutrophils.
Blood smear showing spherocytosis, polychromatoph...

Blood smear showing spherocytosis, polychromatophilia, and erythrophagocytosis by neutrophils.

Blood smear showing spherocytosis, polychromatoph...Media file 2: Blood smear showing spherocytosis, polychromatophilia, and erythrophagocytosis by neutrophils.
Blood smear showing spherocytosis, polychromatoph...

Blood smear showing spherocytosis, polychromatophilia, and erythrophagocytosis by neutrophils.

More on Donath-Landsteiner Hemolytic Anemia

Overview: Donath-Landsteiner Hemolytic Anemia
Differential Diagnoses & Workup: Donath-Landsteiner Hemolytic Anemia
Treatment & Medication: Donath-Landsteiner Hemolytic Anemia
Follow-up: Donath-Landsteiner Hemolytic Anemia
Multimedia: Donath-Landsteiner Hemolytic Anemia
References

References

  1. Donath J LK. Uber paroxysmale Hamoglobinurie. Munchener Medizinische Wochenschrift. 1904;51:1590-3.

  2. Bird GW. Paroxysmal cold haemoglobinuria. Br J Haematol. Oct 1977;37(2):167-71. [Medline].

  3. Gehrs BC, Friedberg RC. Autoimmune hemolytic anemia. Am J Hematol. Apr 2002;69(4):258-71. [Medline].

  4. Petz LD. Cold antibody autoimmune hemolytic anemias. Blood Rev. Jan 2008;22(1):1-15. [Medline].

  5. Sokol RJ, Hewitt S, Stamps BK. Autoimmune haemolysis associated with Donath-Landsteiner antibodies. Acta Haematol. 1982;68(4):268-77. [Medline].

  6. Gottsche B, Salama A, Mueller-Eckhardt C. Donath-Landsteiner autoimmune hemolytic anemia in children. A study of 22 cases. Vox Sang. 1990;58(4):281-6. [Medline].

  7. Sokol RJ, Booker DJ, Stamps R. Erythropoiesis: Paroxysmal Cold Haemoglobinuria: A Clinico-Pathological Study of Patients with a Positive Donath-Landsteiner Test. Hematology. 1999;4(2):137-164. [Medline].

  8. Heddle NM. Acute paroxysmal cold hemoglobinuria. Transfus Med Rev. Jul 1989;3(3):219-29. [Medline].

  9. Sivakumaran M, Murphy PT, Booker DJ, Wood JK, Stamps R, Sokol RJ. Paroxysmal cold haemoglobinuria caused by non-Hodgkin's lymphoma. Br J Haematol. Apr 1999;105(1):278-9. [Medline].

  10. Sharara AI, Hillsley RE, Wax TD, Rosse WF. Paroxysmal cold hemoglobinuria associated with non-Hodgkin's lymphoma. South Med J. Mar 1994;87(3):397-9. [Medline].

  11. Lippman SM, Winn L, Grumet FC, Levitt LJ. Evans' syndrome as a presenting manifestation of atypical paroxysmal cold hemoglobinuria. Am J Med. May 1987;82(5):1065-72. [Medline].

  12. Hernandez JA, Steane SM. Erythrophagocytosis by segmented neutrophils in paroxysmal cold hemoglobinuria. Am J Clin Pathol. Jun 1984;81(6):787-9. [Medline].

  13. Win N, Stamps R, Knight R. Paroxysmal cold haemoglobinuria/Donath-Landsteiner test. Transfus Med. Jun 2005;15(3):254. [Medline].

  14. Gertz MA. Management of cold haemolytic syndrome. Br J Haematol. Aug 2007;138(4):422-9. [Medline].

  15. [Guideline] Gibson BE, Todd A, Roberts I, et al. Transfusion guidelines for neonates and older children. Br J Haematol. Feb 2004;124(4):433-53. [Medline][Full Text].

  16. Roy-Burman A, Glader BE. Resolution of severe Donath-Landsteiner autoimmune hemolytic anemia temporally associated with institution of plasmapheresis. Crit Care Med. Apr 2002;30(4):931-4. [Medline].

  17. Koppel A, Lim S, Osby M, Garratty G, Goldfinger D. Rituximab as successful therapy in a patient with refractory paroxysmal cold hemoglobinuria. Transfusion. Oct 2007;47(10):1902-4. [Medline].

  18. Taylor CJ, Neilson JR, Chandra D, Ibrahim Z. Recurrent paroxysmal cold haemoglobinuria in a 3-year-old child: a case report. Transfus Med. Oct 2003;13(5):319-21. [Medline].

  19. Wolach B, Heddle N, Barr RD, Zipursky A, Pai KR, Blajchman MA. Transient Donath-Landsteiner haemolytic anaemia. Br J Haematol. Jul 1981;48(3):425-34. [Medline].

Further Reading

Keywords

Donath-Landsteiner hemolytic anemia, Donath-Landsteiner syndrome, paroxysmal cold hemoglobinuria, PCH, cryopathic hemolytic syndrome, cold-induced immune hemolytic anemia, autoimmune hemolytic anemia, AIHA, intravascular hemolysis, anemia, biphasic hemolysin, cold hemolytic syndrome, hemolytic anemia, cold agglutinin disease, hepatosplenomegaly, Raynaud phenomenon, cold urticaria, cyanosis, measles, mumps, Epstein-Barr virus, EBV, cytomegalovirus, CMV, varicella zoster virus, adenovirus, coxsackie A9, parvovirus, influenza A, Mycoplasma pneumoniae, Haemophilus influenza, Klebsiella pneumoniae, Escherichia coli, treatment, diagnosis

Contributor Information and Disclosures

Author

M Monica Gramatges, MD, Fellow in Pediatric Hematology/Oncology, Stanford University
M Monica Gramatges, MD is a member of the following medical societies: American Association for Cancer Research, American Society of Clinical Oncology, American Society of Hematology, and American Society of Pediatric Hematology/Oncology
Disclosure: Nothing to disclose.

Coauthor(s)

Michael R Jeng, MD, Associate Professor, Department of Pediatrics, Division of Hematology/Oncology, Stanford University School of Medicine
Michael R Jeng, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Hematology, and American Society of Pediatric Hematology/Oncology
Disclosure: Nothing to disclose.

Medical Editor

Gary R Jones, MD, Associate Medical Director, Clinical Development, Berlex Laboratories
Gary R Jones, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Pediatric Hematology/Oncology, and Western Society for Pediatric Research
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

Gary D Crouch, MD, Program Director of Pediatric Hematology-Oncology Fellowship, Department of Pediatrics, Associate Professor, Uniformed Services University of the Health Sciences
Gary D Crouch, MD is a member of the following medical societies: American Academy of Pediatrics and American Society of Hematology
Disclosure: Nothing to disclose.

CME Editor

Samuel Gross, MD, Professor Emeritus, Department of Pediatrics, University of Florida; Clinical Professor, Department of Pediatrics, University of North Carolina; Adjunct Professor, Department of Pediatrics, Duke University
Samuel Gross, MD is a member of the following medical societies: American Association for Cancer Research, American Society for Blood and Marrow Transplantation, American Society of Clinical Oncology, American Society of Hematology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Chief Editor

Max J Coppes, MD, PhD, MBA, Senior Vice President, Children's National Medical Center (Center for Cancer and Blood Disorders); Director, Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center; Professor of Medicine, Oncology, and Pediatrics, Georgetown University
Max J Coppes, MD, PhD, MBA is a member of the following medical societies: American Association for Cancer Research, American Society of Pediatric Hematology/Oncology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

 
 
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