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Leukocytosis Follow-up

  • Author: Susumu Inoue, MD; Chief Editor: Robert J Arceci, MD, PhD  more...
Updated: Jul 10, 2015


Prognosis totally depends on the underlying etiologies.

Contributor Information and Disclosures

Susumu Inoue, MD Professor of Pediatrics and Human Development, Michigan State University College of Human Medicine; Clinical Professor of Pediatrics, Wayne State University School of Medicine; Director of Pediatric Hematology/Oncology, Associate Director of Pediatric Education, Department of Pediatrics, Hurley Medical Center

Susumu Inoue, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Clinical Oncology, American Society of Hematology, American Society of Pediatric Hematology/Oncology, Society for Pediatric Research

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Gary D Crouch, MD Associate Professor, Program Director of Pediatric Hematology-Oncology Fellowship, Department of Pediatrics, Uniformed Services University of the Health Sciences

Gary D Crouch, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Hematology

Disclosure: Nothing to disclose.

Chief Editor

Robert J Arceci, MD, PhD Director, Children’s Center for Cancer and Blood Disorders, Department of Hematology/Oncology, Co-Director of the Ron Matricaria Institute of Molecular Medicine, Phoenix Children’s Hospital; Editor-in-Chief, Pediatric Blood and Cancer; Professor, Department of Child Health, University of Arizona College of Medicine

Robert J Arceci, MD, PhD is a member of the following medical societies: American Association for the Advancement of Science, American Association for Cancer Research, American Pediatric Society, American Society of Hematology, American Society of Pediatric Hematology/Oncology

Disclosure: Nothing to disclose.


Gary R Jones, MD Associate Medical Director, Clinical Development, Berlex Laboratories

Gary R Jones, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Pediatric Hematology/Oncology, and Western Society for Pediatric Research

Disclosure: Nothing to disclose.

  1. Cotran RS, Kumar V, Collins T. Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: WB Saunders; 1999. 644-96.

  2. Lee GM, Harper MB. Risk of bacteremia for febrile young children in the post-Haemophilus influenzae type b era. Arch Pediatr Adolesc Med. 1998 Jul. 152(7):624-8. [Medline].

  3. Brown L, Shaw T, Wittlake WA. Does leucocytosis identify bacterial infections in febrile neonates presenting to the emergency department?. Emerg Med J. 2005 Apr. 22(4):256-9. [Medline].

  4. Hsiao AL, Chen L, Baker D. Incidence and predictors of serious bacterial infections among 57- to 180-day-old infants. Pediatrics. May 2006. 117:1695-1701.

  5. Hsiao R, Omar SA. Outcome of extremely low birth weight infants with leukemoid reaction. Pediatrics. 2005 Jul. 116(1):e43-51. [Medline].

  6. Zanardo V, Vedovato S, Trevisanuto DD, Suppiej A, Cosmi E, Fais GF. Histological chorioamnionitis and neonatal leukemoid reaction in low-birth-weight infants. Hum Pathol. 2006 Jan. 37(1):87-91. [Medline].

  7. Arav-Boger R, Baggett HC, Spevak PJ, Willoughby RE. Leukocytosis caused by prostaglandin E1 in neonates. J Pediatr. 2001 Feb. 138(2):263-5. [Medline].

  8. Talosi G, Katona M, Turi S. Side-effects of long-term prostaglandin E(1) treatment in neonates. Pediatr Int. 2007 Jun. 49(3):335-40. [Medline].

  9. Ballin A, Lehman D, Sirota P, Litvinjuk U, Meytes D. Increased number of peripheral blood CD34+ cells in lithium-treated patients. Br J Haematol. 1998 Jan. 100(1):219-21. [Medline].

  10. Zhang S, Condac E, Qiu H, et al. Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice. J Biol Chem. 2012 Feb 17. 287(8):5542-53. [Medline]. [Full Text].

  11. Allam JP, Paus T, Reichel C, Bieber T, Novak N. DRESS syndrome associated with carbamazepine and phenytoin. Eur J Dermatol. 2004 Sep-Oct. 14(5):339-42. [Medline].

  12. Gungor E, Alli N, Comoglu S, Comcuoglu C. Phenytoin hypersensitivity syndrome. Neurol Sci. 2001 Jun. 22(3):261-5. [Medline].

  13. Lupton JR, Figueroa P, Tamjidi P, Berberian BJ, Sulica VI. An infectious mononucleosis-like syndrome induced by minocycline: a third pattern of adverse drug reaction. Cutis. 1999 Aug. 64(2):91-6. [Medline].

  14. Liu F, Mahgoub N, Ferrando S. Leukocytosis associated with clozapine treatment: a case report. Psychosomatics. 2011 Sep-Oct. 52(5):488-91. [Medline].

  15. Shpall RL, Jeffes EW, Hoffman HM. A case of familial cold autoinflammatory syndrome confirmed by the presence of a CIAS1 mutation. Br J Dermatol. 2004 May. 150(5):1029-31. [Medline].

  16. Granger JM, Kontoyiannis DP. Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients: a retrospective, single-institution study. Cancer. 2009 Sep 1. 115(17):3919-23. [Medline].

  17. Alizadeh P, Rahbarimanesh AA, Bahram MG, Salmasian H. Leukocyte adhesion deficiency type 1 presenting as leukemoid reaction. Indian J Pediatr. 2007 Dec. 74(12):1121-3. [Medline].

  18. Rosa JS, Schwindt CD, Oliver SR, Leu SY, Flores RL, Galassetti PR. Exercise leukocyte profiles in healthy, type 1 diabetic, overweight, and asthmatic children. Pediatr Exerc Sci. 2009 Feb. 21(1):19-33. [Medline].

  19. Aydogan M, Aydogan A, Kara B, Basim B, Erdogan S. Transient peripheral leukocytosis in children with afebrile seizures. J Child Neurol. 2007 Jan. 22(1):77-9. [Medline].

  20. Alioglu B, Ozyurek E, Avci Z, Atalay B, Caner H, Ozbek N. Peripheral blood picture following mild head trauma in children. Pediatr Int. 2008 Jun. 50(3):281-3. [Medline].

  21. Furlan JC, Krassioukov AV, Fehlings MG. Hematologicl abnormalities within the first week after acute isolated traumatic cervical spinal cord injury: a case-control cohort study. Spine. Nov/2006. 31:2674-83. [Medline].

  22. Osawa I, Nagamachi S, Suzuki H et al. Leukocytosis and high hematocrit levels during abdominal attacks of hereditary angioedema. BMC Gastroenterology 2013, 13:123. August/2013. 13:123.

  23. Plo I, Zhang Y, Le Couédic JP, Nakatake M, Boulet JM, Itaya M. An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia. J Exp Med. 2009 Aug 3. 206(8):1701-7. [Medline]. [Full Text].

  24. Snyder RL, Stringham DJ. Pegfilgrastim-induced hyperleukocytosis. Ann Pharmacother. 2007 Sep. 41(9):1524-30. [Medline].

  25. Duchin JS, Koster FT, Peters CJ, et al. Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The Hantavirus Study Group. N Engl J Med. 1994 Apr 7. 330(14):949-55. [Medline].

  26. Drago F, Cogorno L, Agnoletti AF, Parodi A. Role of peripheral eosinophilia in adverse cutaneous drug reactions. Eur Rev Med Pharmacol Sci. 2015 Jun. 19 (11):2008-9. [Medline].

  27. Cherfane CE, Gessel L, Cirillo D, Zimmerman MB, Polyak S. Monocytosis and a Low Lymphocyte to Monocyte Ratio Are Effective Biomarkers of Ulcerative Colitis Disease Activity. Inflamm Bowel Dis. 2015 May 19. [Medline].

  28. Arav-Boger R, Baggett HC, Spevak PJ, Willoughby RE. Leukocytosis caused by prostaglandin E1 in neonates. J Pediatr. 2001 Feb. 138(2):263-5. [Medline].

  29. Bonadio WA. Evaluation and management of serious bacterial infections in the febrile young infant. Pediatr Infect Dis J. 1990 Dec. 9(12):905-12. [Medline].

  30. Dinauer MC. The phagocyte system and disorders of granulopoiesis and granulocyte function. Nathan and Oski's Hematology of Infancy and Childhood. 5th ed. Philadelphia, PA: WB Saunders; 1998. Vol 1: 889.

  31. Izbicki G, Rudensky B, Na'amad M, Hershko C, Huerta M, Hersch M. Transfusion-related leukocytosis in critically ill patients. Crit Care Med. 2004 Feb. 32(2):439-42. [Medline].

  32. Lichtman MA, Rowe JM. Hyperleukocytic leukemias: rheological, clinical, and therapeutic considerations. Blood. 1982 Aug. 60(2):279-83. [Medline].

  33. Shah SS, Shofer FS, Seidel JS, Baren JM. Significance of extreme leukocytosis in the evaluation of febrile children. Pediatr Infect Dis J. 2005 Jul. 24(7):627-30. [Medline].

  34. Wang, CW, Lukens JN. Sickle cell anemia and other sickling syndromes. Wintrobe's Clinical Hematology. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1999. Vol 1: 1346-97.

  35. Wright IM, Skinner AM. Post-transfusion white cell count in the sick preterm neonate. J Paediatr Child Health. 2001 Feb. 37(1):44-6. [Medline].

WBC counts.
Table. Normal Leukocyte Counts
  Total Leukocytes* Lymphocytes Neutrophils Monocytes Eosinophils
Age MeanRange MeanRange% MeanRange% Mean% Mean%
Birth ...... 4.22-7.3... 42-6... 0.6... 0.1...
12 h ...... 4.22-7.3... 117.8-14.5... 0.6... 0.1...
24 h ...... 4.22-7.3... 97-12... 0.6... 0.1...
1-4 wk ...... 5.62.9-9.1... 3.61.8-5.4... 0.7... 0.2...
6 mo 11.96-17.5 7.34-13.561 3.81-8.532 0.65 0.33
1 y 11.46-17.5 7.04-10.561 3.51.5-8.531 0.65 0.33
2 y 10.66-17 6.33-9.559 3.51.5-8.533 0.55 0.33
4 y 9.15.5-15.5 4.52-850 3.81.5-8.542 0.55 0.33
6 y 8.55-14.5 3.51.5-742 4.31.5-851 0.45 0.23
8 y 8.34.5-13.5 3.31.5-6.839 4.41.5-853 0.44 0.22
10 y 8.14.5-13.5 3.11.5-6.538 4.41.8-854 0.44 0.22
16 y 7.84.5-13 2.81.2-5.235 4.41.8-857 0.45 0.23
21 y 7.44.5-11 2.51-4.834 4.41.8-7.759 0.34 0.23

* Numbers of leukocytes are in X 109 \L or thousands per μ L; ranges are estimates of 95% confidence limits; and percentages refer to differential counts.

Neutrophils include band cells at all ages and a small number of metamyelocytes and myelocytes in the first few days of life.

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