Pars Interarticularis Injury Medication
- Author: Gerard A Malanga, MD; Chief Editor: Craig C Young, MD more...
Medication Summary
Medications recommended for the treatment of pain in spondylolysis include nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and muscle relaxants. Before prescribing these medications, review the contraindications, adverse side effects, and mode of action.
Nonsteroidal Anti-inflammatory Drugs
Class Summary
NSAIDs have analgesic, anti-inflammatory, and antipyretic activities. The mechanism of action of these agents is not known, but NSAIDs may inhibit cyclooxygenase activity and prostaglandin synthesis. Other mechanisms may include leukotriene synthesis inhibition, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation and various cell membrane functions.
Ibuprofen (Ibuprin, Motrin)
DOC for patients with mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis. The anti-inflammatory dose is higher than the analgesic dose. Newer generation NSAIDs have a lower risk of gastrointestinal risk because they selectively interact with COX–2 receptors. Prolonged use of the medication is generally not recommended.
Celecoxib (Celebrex)
Inhibits primarily COX-2. COX-2 is considered an inducible isoenzyme, induced by pain and inflammatory stimuli. Inhibition of COX-1 may contribute to NSAID GI toxicity. At therapeutic concentrations, COX-1 isoenzyme is not inhibited, thus, GI toxicity may be decreased. Seek the lowest dose of celecoxib for each patient.
Naproxen (Naprosyn, Naprelan, Anaprox)
For relief of mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing the activity of COX, which is responsible for prostaglandin synthesis.
Muscle Relaxants
Class Summary
Muscle relaxants help to relax tight muscles and can be used in conjunction with NSAIDs.
Cyclobenzaprine (Flexeril)
Muscle relaxants may be helpful in some patients with LBP and seem to have additional benefits when used in conjunction with NSAIDs. Muscle relaxants can be used as short-term adjunctive medications and should be taken hs to take advantage of their sedating side effects.
Analgesics
Class Summary
Pain control is essential to quality patient care. Analgesics ensure patient comfort and have sedating properties, which are beneficial for patients who have sustained trauma or who have sustained injuries.
Acetaminophen (Tylenol, Feverall, Tempra)
Offers pain relief without the increased risk of bleeding for patients with contraindications to the use of NSAIDs.
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| Plain Radiograph | SPECT Scan | Interpretation | Management |
| Negative | Negative | Pathology other than pars defect should be suspected | Further investigation of cause of back pain should be performed (eg, MRI) |
| Negative | Positive | Early pars interarticularis fracture | Conservative management in form of rest, +/– bracing |
| Positive | Healing | Spondylolysis | Conservative management in the form of rest and bracing |
| Positive | Negative | Pseudoarthrosis or old unhealed fracture | Consider surgical intervention for stabilization to prevent spondylolisthesis and to relieve pain. Consider further investigation to rule out alternative pathology. |

