eMedicine Specialties > Pediatrics: General Medicine > Hematology
Transient Erythroblastopenia of Childhood: Treatment & Medication
Updated: Sep 4, 2009
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
Treatment
Medical Care
- Packed red cell transfusions are required in patients with severe transient erythroblastopenia of childhood (TEC) when signs of clinical decompensation are evident. Conditions in which transfusion may be necessary include hemodynamic instability, exercise intolerance, or altered mental status.
- Refractory incidents of transient erythroblastopenia of childhood may be associated with a failure to thrive and also may require packed red cell transfusion.
- Perform nonemergent transfusions in consultation with a pediatric hematologist.
Consultations
- Consultation with a pediatric hematologist is recommended in nonclassic presentations of transient erythroblastopenia of childhood or if the patient with transient erythroblastopenia of childhood has severe anemia that requires transfusion.
Diet
- No special dietary requirements are necessary.
Medication
- Treatment with corticosteroids and erythropoietin is unnecessary. Difficulty in distinguishing Diamond-Blackfan anemia (a corticosteroid-responsive condition) from transient erythroblastopenia of childhood (TEC) has led to corticosteroid treatment and subsequent resolution in some individuals with transient erythroblastopenia of childhood.
- Whether these isolated reports are true incidents of corticosteroid-responsive transient erythroblastopenia of childhood or whether the anemia can resolve independently of corticosteroid treatment is unclear.
More on Transient Erythroblastopenia of Childhood |
| Overview: Transient Erythroblastopenia of Childhood |
| Differential Diagnoses & Workup: Transient Erythroblastopenia of Childhood |
Treatment & Medication: Transient Erythroblastopenia of Childhood |
| Follow-up: Transient Erythroblastopenia of Childhood |
| References |
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References
Prassouli A, Papadakis V, Tsakris A, et al. Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. J Pediatr Hematol Oncol. Jun 2005;27(6):333-6. [Medline].
Geetha D, Zachary JB, Baldado HM, et al. Pure red cell aplasia caused by Parvovirus B19 infection in solid organ transplant recipients: a case report and review of literature. Clin Transplant. Dec 2000;14(6):586-91. [Medline].
Skeppner G, Kreuger A, Elinder G. Transient erythroblastopenia of childhood: prospective study of 10patients with special reference to viral infections. J Pediatr Hematol Oncol. May 2002;24(4):294-8. [Medline].
Shaw J, Meeder R. Transient erythroblastopenia of childhood in siblings: case report and review of the literature. J Pediatr Hematol Oncol. Sep 2007;29(9):659-60. [Medline].
Chabali R. Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. Pediatr Emerg Care. Oct 1994;10(5):278-80. [Medline].
Martinez Barrio A, Eriksson O, Badhai J, et al. Targeted resequencing and analysis of the Diamond-Blackfan anemia disease locus RPS19. PLoS One. Jul 9 2009;4(7):e6172. [Medline].
Chan GC, Kanwar VS, Wilimas J. Transient erythroblastopenia of childhood associated with transient neurologic deficit: report of a case and review of the literature. J Paediatr Child Health. Jun 1998;34(3):299-301. [Medline].
Cherrick I, Karayalcin G, Lanzkowsky P. Transient erythroblastopenia of childhood. Prospective study of fifty patients. Am J Pediatr Hematol Oncol. Nov 1994;16(4):320-4. [Medline].
Freedman MH. 'Recurrent' erythroblastopenia of childhood. An IgM-mediated RBC aplasia. Am J Dis Child. May 1983;137(5):458-60. [Medline].
Gussetis ES, Peristeri J, Kitra V, et al. Clinical value of bone marrow cultures in childhood pure red cell aplasia. J Pediatr Hematol Oncol. Mar-Apr 1998;20(2):120-4. [Medline].
Gustavsson P, Klar J, Matsson H, et al. Familial transient erythroblastopenia of childhood is associated with thechromosome 19q13.2 region but not caused by mutations in coding sequencesof the ribosomal protein S19 (RPS19) gene. Br J Haematol. Oct 2002;119(1):261-4. [Medline].
Krijanovski OI, Sieff CA. Diamond-Blackfan anemia. Hematol Oncol Clin North Am. Dec 1997;11(6):1061-77. [Medline].
Miller R, Berman B. Transient erythroblastopenia of childhood in infants < 6 months of age. Am J Pediatr Hematol Oncol. Aug 1994;16(3):246-8. [Medline].
Mupanomunda OK, Alter BP. Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia. J Pediatr Hematol Oncol. Mar-Apr 1997;19(2):165-7. [Medline].
Tam DA, Rash FC. Breath-holding spells in a patient with transient erythroblastopenia of childhood. J Pediatr. Apr 1997;130(4):651-3. [Medline].
Walters MC, Abelson HT. Interpretation of the complete blood count. Pediatr Clin North Am. Jun 1996;43(3):599-622. [Medline].
Further Reading
Keywords
transient erythroblastopenia of childhood, TEC, anemia, pallor, pure red cell aplasia, human parvovirus B19, Diamond-Blackfan anemia, aplastic crises, hyperhemolytic crises, hemoglobinopathy, sickle cell disease, hereditary spherocytosis, splenomegaly, icterus, hemolytic-associated anemia, sequestration-associated anemia, aplastic anemia
Treatment & Medication: Transient Erythroblastopenia of Childhood