Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

Pediatric Aspergillosis Differential Diagnoses

  • Author: Vandana Batra, MD; Chief Editor: Russell W Steele, MD  more...
 
Updated: Aug 16, 2016
 
 

Diagnostic Considerations

See the list below:

  • Sinusitis: Evaluate patients whose chronic sinusitis does not respond to broad-spectrum antibacterial antibiotics for the possibility of invasive aspergillosis (IA).
  • Infection in patients with granulocytopenia: Consider aspergillosis in patients with granulocytopenia who develop signs and symptoms of infection.

Differential Diagnoses

 
 
Contributor Information and Disclosures
Author

Vandana Batra, MD Fellow, Department of Pediatric Hematology Oncology, Children's Hospital of Philadelphia

Vandana Batra, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Coauthor(s)

Jocelyn Y Ang, MD, FAAP, FIDSA Associate Professor, Department of Pediatrics, Wayne State University School of Medicine; Consulting Staff, Division of Infectious Diseases, Children's Hospital of Michigan

Jocelyn Y Ang, MD, FAAP, FIDSA is a member of the following medical societies: American Academy of Pediatrics, Infectious Diseases Society of America, Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Basim Asmar, MD Director, Department of Pediatrics, Division of Infectious Diseases, Children's Hospital of Michigan; Professor, Department of Pediatrics, Wayne State University School of Medicine

Basim Asmar, MD is a member of the following medical societies: American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Mark R Schleiss, MD Minnesota American Legion and Auxiliary Heart Research Foundation Chair of Pediatrics, Professor of Pediatrics, Division Director, Division of Infectious Diseases and Immunology, Department of Pediatrics, University of Minnesota Medical School

Mark R Schleiss, MD is a member of the following medical societies: American Pediatric Society, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Russell W Steele, MD Clinical Professor, Tulane University School of Medicine; Staff Physician, Ochsner Clinic Foundation

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, Southern Medical Association

Disclosure: Nothing to disclose.

Additional Contributors

Itzhak Brook, MD, MSc Professor, Department of Pediatrics, Georgetown University School of Medicine

Itzhak Brook, MD, MSc is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians-American Society of Internal Medicine, American Medical Association, American Society for Microbiology, Association of Military Surgeons of the US, Infectious Diseases Society of America, International Immunocompromised Host Society, International Society for Infectious Diseases, Medical Society of the District of Columbia, New York Academy of Sciences, Pediatric Infectious Diseases Society, Society for Experimental Biology and Medicine, Society for Pediatric Research, Southern Medical Association, Society for Ear, Nose and Throat Advances in Children, American Federation for Clinical Research, Surgical Infection Society, Armed Forces Infectious Diseases Society

Disclosure: Nothing to disclose.

References
  1. Tragiannidis A, Roilides E, Walsh TJ, Groll AH. Invasive Aspergillosis in Children With Acquired Immunodeficiencies. Clin Infect Dis. 2011 Nov 10. [Medline].

  2. Greenberger PA, Patterson R. Diagnosis and management of allergic bronchopulmonary aspergillosis. Ann Allergy. 1986 Jun. 56(6):444-8. [Medline].

  3. Fisher BT, Zaoutis TE, Park JR, Bleakley M, Englund JA, Kane C, et al. Galactomannan Antigen Testing for Diagnosis of Invasive Aspergillosis in Pediatric Hematology Patients. J Pediatric Infect Dis Soc. 2012 Jun. 1(2):103-111. [Medline]. [Full Text].

  4. Pickering JW, Sant HW, Bowles CA, Roberts WL, Woods GL. Evaluation of a (1->3)-beta-D-glucan assay for diagnosis of invasive fungal infections. J Clin Microbiol. 2005 Dec. 43(12):5957-62. [Medline]. [Full Text].

  5. Desmet S, Van Wijngaerden E, Maertens J, et al. Serum (1-3)-beta-D-glucan as a tool for diagnosis of Pneumocystis jirovecii pneumonia in patients with human immunodeficiency virus infection or hematological malignancy. J Clin Microbiol. 2009 Dec. 47(12):3871-4. [Medline]. [Full Text].

  6. Aquino VR, Goldani LZ, Pasqualotto AC. Update on the contribution of galactomannan for the diagnosis of invasive aspergillosis. Mycopathologia. 2007 Apr. 163(4):191-202. [Medline].

  7. Pfeiffer CD, Fine JP, Safdar N. Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis. Clin Infect Dis. 2006 May 15. 42(10):1417-727. [Medline].

  8. Francesconi A, Kasai M, Petraitiene R, et al. Characterization and comparison of galactomannan enzyme immunoassay and quantitative real-time PCR assay for detection of Aspergillus fumigatus in bronchoalveolar lavage fluid from experimental invasive pulmonary aspergillosis. J Clin Microbiol. 2006 Jul. 44(7):2475-80. [Medline].

  9. Choi SH, Kang ES, Eo H, Yoo SY, Kim JH, Yoo KH, et al. Aspergillus galactomannan antigen assay and invasive aspergillosis in pediatric cancer patients and hematopoietic stem cell transplant recipients. Pediatr Blood Cancer. 2013 Feb. 60(2):316-22. [Medline].

  10. Koo S, Thomas HR, Daniels SD, Lynch RC, Fortier SM, Shea MM, et al. A breath fungal secondary metabolite signature to diagnose invasive aspergillosis. Clin Infect Dis. 2014 Dec 15. 59 (12):1733-40. [Medline].

  11. Skwarecki B. Breath Test May Diagnose Fungal Pneumonia. Medscape Medical News. Available at http://www.medscape.com/viewarticle/834035. October 29, 2014; Accessed: December 29, 2015.

  12. de Benedictis FM, Bush A. Corticosteroids in Respiratory Diseases in Children. Am J Respir Crit Care Med. 2011 Sep 15. [Medline].

  13. Jat KR, Walia DK, Khairwa A. Anti-IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis. Cochrane Database Syst Rev. 2013 Sep 17. 9:CD010288. [Medline].

  14. Patterson TF, Thompson GR 3rd, Denning DW, Fishman JA, Hadley S, Herbrecht R, et al. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Aug 15. 63 (4):e1-e60. [Medline].

  15. Parry NM. New Guidelines for the Management of Aspergillosi. Medscape Medical News. Available at http://www.medscape.com/viewarticle/865689. July 05, 2016; Accessed: August 16, 2016.

  16. Kamalaporn H, Leung K, Nagel M, Kittanakom S, Calvieri B, Reithmeier RA, et al. Aerosolized liposomal amphotericin B: A potential prophylaxis of invasive pulmonary aspergillosis in immunocompromised patients. Pediatr Pulmonol. 2013 Jul 10. [Medline].

  17. Abbasi S, Shenep JL, Hughes WT, Flynn PM. Aspergillosis in children with cancer: A 34-year experience. Clin Infect Dis. 1999 Nov. 29(5):1210-9. [Medline].

  18. Blum MD, Weidermann BL. Aspergillus infections. Feigin RD, Cherry JD, eds. Textbook of Pediatric Infectious Diseases. 5th ed. W B Saunders and Co; 2004. Vol 2: 2288-96.

  19. Denning DW. Invasive aspergillosis. Clin Infect Dis. 1998 Apr. 26(4):781-803; quiz 804-5. [Medline].

  20. Dismukes WE. Antifungal therapy: lessons learned over the past 27 years. Clin Infect Dis. 2006 May 1. 42(9):1289-96. [Medline].

  21. Hetherington S. Etiologic agents of infectious disease. Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 1st ed. Churchill Livingstone; 1997. 1326-32.

  22. Kuhlman JE, Fishman EK, Burch PA, et al. Invasive pulmonary aspergillosis in acute leukemia. The contribution of CT to early diagnosis and aggressive management. Chest. 1987 Jul. 92(1):95-9. [Medline].

  23. Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev. 1999 Apr. 12(2):310-50. [Medline].

  24. McWhinney PH, Kibbler CC, Hamon MD, et al. Progress in the diagnosis and management of aspergillosis in bone marrow transplantation: 13 years' experience. Clin Infect Dis. 1993 Sep. 17(3):397-404. [Medline].

  25. Patterson TF. Aspergillus species. Mandell GL, Benett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 6th ed. Churchill Livingstone; 2005. Vol 2: 2958-70.

  26. Pickering LK. Aspergillosis. Pickering LK, ed. 2003 Red Book: Report of the Committee on Infectious Diseases. 26th ed. Elk Grove, IL: American Academy of Pediatrics; 2003. 208-10,725.

  27. Segal BH, Walsh TJ. Current approaches to diagnosis and treatment of invasive aspergillosis. Am J Respir Crit Care Med. 2006 Apr 1. 173(7):707-17. [Medline].

  28. Steinbach WJ. Antifungal agents in children. Pediatr Clin North Am. 2005 Jun. 52(3):895-915, viii. [Medline].

  29. Steinbach WJ. Pediatric aspergillosis: disease and treatment differences in children. Pediatr Infect Dis J. 2005 Apr. 24(4):358-64. [Medline].

  30. Stevens DA, Kan VL, Judson MA, et al. Practice guidelines for diseases caused by Aspergillus. Infectious Diseases Society of America. Clin Infect Dis. 2000 Apr. 30(4):696-709. [Medline].

  31. Walmsley S, Devi S, King S, et al. Invasive Aspergillus infections in a pediatric hospital: a ten-year review. Pediatr Infect Dis J. 1993 Aug. 12(8):673-82. [Medline].

  32. Walsh TJ, Hiemenz JW, Seibel NL, et al. Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases. Clin Infect Dis. 1998 Jun. 26(6):1383-96. [Medline].

  33. White PL, Linton CJ, Perry MD, et al. The evolution and evaluation of a whole blood polymerase chain reaction assay for the detection of invasive aspergillosis in hematology patients in a routine clinical setting. Clin Infect Dis. 2006 Feb 15. 42(4):479-86. [Medline].

  34. Zaoutis TE, Heydon K, Chu JH, et al. Epidemiology, outcomes, and costs of invasive aspergillosis in immunocompromised children in the United States, 2000. Pediatrics. 2006 Apr. 117(4):e711-6. [Medline].

Previous
Next
 
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.