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Thoracic Outlet Syndrome Clinical Presentation

  • Author: Daryl A Rosenbaum, MD; Chief Editor: Sherwin SW Ho, MD  more...
Updated: Sep 13, 2015


The initial presentation of thoracic outlet syndrome is dependent on whether the compression is primarily vascular, neurogenic, or a combination of both. It is also dependent on the underlying continuum of histopathologic changes noted with chronic nerve compression, ranging from intermittent to constant debilitating symptoms.[15] Three symptomatic patterns emerge; these are vascular, true neurogenic, and disputed or nonspecific-type thoracic outlet syndrome.

Vascular thoracic outlet syndrome is rare and can involve the subclavian artery or vein. Both forms of vascular thoracic outlet syndrome tend to occur in young patients who perform vigorous overhead arm activity such as throwing. With venous obstruction (if secondary to thrombosis, Paget-von Schrötter syndrome), patients may present with upper extremity swelling, venous distention, or diffuse arm or hand pain (including the forearm).[15, 16]

With arterial obstruction, patients may report color changes of their affected upper extremity, claudication, or diffuse arm or hand pain (including the forearm). Because of arterial collateral blood flow, the initial symptoms tend to be mild, with arm ache and fatigue, particularly after overhead activity. Patients typically seek medical evaluation after ischemic events (eg, ulceration, gangrene, absent pulses) occur.[15]

Neurogenic thoracic outlet syndrome involves compression of the brachial plexus. Similar to vascular thoracic outlet syndrome, a pure neurogenic presentation is also rare. Patients present with painless atrophy of the intrinsic muscles of the hand, and athletes may report difficulty grasping a racket or ball as a result of intrinsic muscle weakness. They may also report sensory loss or paresthesias. Pain is often reported but is not as dramatic as in the nonspecific-type thoracic outlet syndrome.[10] Again, neurogenic thoracic outlet syndrome tends to affect individuals who perform overhead arm activities.

The disputed or nonspecific-type thoracic outlet syndrome refers to a large group of patients with unexplained pain in the arm, scapular region, and cervical region. Typically, their symptoms begin after a traumatic event (eg, motor vehicle accident). Much debate surrounds this diagnosis, with certain providers believing the disorder is underdiagnosed.[7] and others believing it is overdiagnosed.[8]



The examination should begin with an assessment of the patient’s posture. A slumped posture of the shoulders and upper back and a “poked-forward” position of the head and neck are comfortable but potentially damaging for the scapular and neck muscles and are thought to contribute to the susceptibility for thoracic outlet syndrome.[15]

The symmetry of both arms should be evaluated. Cervical active range-of-motion assessment and the Spurling test (ie, patient’s head is placed in extension and lateral flexion, with axial compression applied by the examiner to the patient’s head in an effort to recreate radicular pain) should be performed. Active and passive range of motion of both shoulders should be examined. A careful neurovascular examination of both upper extremities is needed, taking care to remember that the muscles and nerves supplied by the lower brachial plexus are most commonly affected.

Vascular thoracic outlet syndrome has different examination signs depending on whether the venous or arterial vessels are affected. With venous compression, patients often present with edema and cyanosis of the upper extremity. They may also have distended veins in the shoulder or chest. With arterial compression, patients often present with pallor, a weak or absent pulse, and coolness of the upper extremity. Decreased blood pressure greater than 20 mm Hg in the affected arm compared with the contralateral arm is sometimes noted and is a reliable indicator of arterial involvement.[10] Rarely, small infarcts are noted in the hands and fingers, which are due to embolization.

The classic finding in a person with neurogenic thoracic outlet syndrome is the Gilliatt-Sumner hand. This physical examination finding includes atrophy of the abductor pollicis brevis with lesser involvement of the interossei and hypothenar muscles.[10] Patients may also have decreased sensation that follows the ulnar nerve distribution because the lower trunks of the brachial plexus are usually more involved than the upper trunks.

Patients with disputed or nonspecific-type thoracic outlet syndrome tend to have diffuse upper extremity pain with guarding. Examination tends to be difficult and findings nonfocal. Weakness and decreased sensation tend to be unreliable signs that are difficult to quantify.

Because of the variability of the structures involved in thoracic outlet syndrome, many provocative maneuvers have been described to aid in diagnosis. They include the Adson maneuver, Wright test, and Roos stress test.[11, 15] Note, however, that these tests have high rates of false-positive and false-negative results.[15]

The Adson maneuver is performed by positioning the tested shoulder in slight abduction and extension. Then, the patient extends his or her neck and turns the head toward this affected shoulder. The patient inhales while the examiner simultaneously palpates the ipsilateral radial pulse. If the pulse diminishes or the patient has paresthesias, the test result is considered positive as long as this maneuver does not cause symptoms on the asymptomatic contralateral side.

The Wright test is performed by progressively hyperabducting and externally rotating the patient’s affected arm while assessing the ipsilateral radial pulse. Again, the test result is considered positive if the pulse diminishes or paresthesias develop.[11]

The Roos stress test is performed with the patient positioning both of his or her shoulders in abduction and external rotation of 90° with elbow flexion at 90°. The patient then opens and closes his or her hands for several minutes. Reproduction of symptoms or a sensation of heaviness or fatigue is considered a positive test result.[11]



Causes of thoracic outlet syndrome can be divided into bony and soft-tissue factors. Bony factors include abnormalities such as anomalous cervical ribs, hypoplastic first thoracic ribs, and exostoses of the first rib or clavicle.[17, 18] The rate of anomalous cervical ribs is considered to be 0.17-0.74% in the general population, and the rate of rudimentary first ribs is 0.29-0.76%.[15]

Soft-tissue factors include congenital anomalies such as anomalous fibrous muscular bands near the brachial plexus and hypertrophic muscles in athletes and weight lifters.[18, 19] Space-occupying lesions (eg, tumors, cysts) and inflammatory processes also occur in the soft tissues and can cause thoracic outlet syndrome.

Trauma or mechanical stress to the neck, shoulders, or upper extremities can lead to thoracic outlet syndrome. In fact, a combination of neck trauma and anatomic predisposition (ie, cervical rib) is considered the main etiology of thoracic outlet syndrome. Posttraumatic conditions such as hematoma, myositis ossificans, and scar formation can be important variables, as can a droopy shoulder secondary to trapezius muscle weakness.[20] Thoracic outlet syndrome can be secondary to malunion of a clavicle fracture.[21]

Interestingly, multiple points of compression may be present as the peripheral nerves descend from the thoracic outlet to the hand (simultaneous thoracic outlet syndrome and ulnar nerve compression at the elbow or carpal tunnel syndrome in the wrist). This has been referred to as double-[22] or multiple-crush syndrome.[23]

Contributor Information and Disclosures

Daryl A Rosenbaum, MD Associate Professor, Director of Sports Medicine Fellowship, Department of Family and Community Medicine, Wake Forest University School of Medicine

Daryl A Rosenbaum, MD is a member of the following medical societies: American Academy of Family Physicians, American Medical Society for Sports Medicine, North Carolina Medical Society

Disclosure: Nothing to disclose.


Matt Thornburg, MD Staff Physician, Department of Family and Community Medicine, University of Missouri Health Care at Columbia

Matt Thornburg, MD is a member of the following medical societies: American Academy of Family Physicians, American Medical Association

Disclosure: Nothing to disclose.

Matthew L Silvis, MD Assistant Professor, Departments of Family and Community Medicine and Orthopedics and Rehabilitation, Pennsylvania State University College of Medicine

Matthew L Silvis, MD is a member of the following medical societies: American Academy of Family Physicians, American Medical Society for Sports Medicine

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Russell D White, MD Clinical Professor of Medicine, Clinical Professor of Orthopedic Surgery, Department of Community and Family Medicine, University of Missouri-Kansas City School of Medicine, Truman Medical Center-Lakewood

Russell D White, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Family Physicians, American Association of Clinical Endocrinologists, American College of Sports Medicine, American Diabetes Association, American Medical Society for Sports Medicine

Disclosure: Nothing to disclose.

Chief Editor

Sherwin SW Ho, MD Associate Professor, Department of Surgery, Section of Orthopedic Surgery and Rehabilitation Medicine, University of Chicago Division of the Biological Sciences, The Pritzker School of Medicine

Sherwin SW Ho, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, Arthroscopy Association of North America, Herodicus Society, American Orthopaedic Society for Sports Medicine

Disclosure: Received consulting fee from Biomet, Inc. for speaking and teaching; Received grant/research funds from Smith and Nephew for fellowship funding; Received grant/research funds from DJ Ortho for course funding; Received grant/research funds from Athletico Physical Therapy for course, research funding; Received royalty from Biomet, Inc. for consulting.

Additional Contributors

Craig C Young, MD Professor, Departments of Orthopedic Surgery and Community and Family Medicine, Medical Director of Sports Medicine, Medical College of Wisconsin

Craig C Young, MD is a member of the following medical societies: American Academy of Family Physicians, American College of Sports Medicine, American Medical Society for Sports Medicine, Phi Beta Kappa

Disclosure: Nothing to disclose.


Ajay Kalra, MD Consulting Surgeon, Surgical Specialists

Ajay Kalra, MD is a member of the following medical societies: Missouri State Medical Association

Disclosure: Nothing to disclose.

Donald Spadone, MD Assistant Professor, Department of Surgery, Division of Vascular Surgery, University of Missouri Health Sciences Center

Donald Spadone, MD is a member of the following medical societies: American College of Surgeons, American Institute of Ultrasound in Medicine, Association for Academic Surgery, Association for Surgical Education, and Society of Critical Care Medicine

Disclosure: Nothing to disclose.

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Thoracic outlet syndrome in a 16-year-old volleyball player with a stenotic right subclavian vein (arrow) secondary to fibrosis.
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