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Pediatric Hantavirus Pulmonary Syndrome Medication

  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: Russell W Steele, MD  more...
 
Updated: Nov 26, 2014
 
 

Medication Summary

Drug therapy is not currently a component of the standard of care for this infection. No specific therapy has been found to be of benefit. Ribavirin therapy has proved inconclusive in the open-label studies. A controlled trial of ribavirin in Hantavirus pulmonary syndrome is underway.[10]

 
 
Contributor Information and Disclosures
Author

Vinod K Dhawan, MD, FACP, FRCPC, FIDSA Professor, Department of Clinical Medicine, University of California, Los Angeles, David Geffen School of Medicine; Chief, Division of Infectious Diseases, Rancho Los Amigos National Rehabilitation Center

Vinod K Dhawan, MD, FACP, FRCPC, FIDSA is a member of the following medical societies: American College of Physicians, American Medical Association, American Society for Microbiology, Infectious Diseases Society of America, Royal College of Physicians and Surgeons of Canada

Disclosure: Received honoraria from Pfizer Inc for speaking and teaching.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Mark R Schleiss, MD Minnesota American Legion and Auxiliary Heart Research Foundation Chair of Pediatrics, Professor of Pediatrics, Division Director, Division of Infectious Diseases and Immunology, Department of Pediatrics, University of Minnesota Medical School

Mark R Schleiss, MD is a member of the following medical societies: American Pediatric Society, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Russell W Steele, MD Clinical Professor, Tulane University School of Medicine; Staff Physician, Ochsner Clinic Foundation

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, Southern Medical Association

Disclosure: Nothing to disclose.

Acknowledgements

Maria A Horga, MD Assistant Professor, Department of Pediatric Infectious Diseases, Bristol-Myers Squibb

Disclosure: Nothing to disclose.

Rosemary Johann-Liang, MD Medical Officer, Infectious Diseases and Pediatrics, Division of Special Pathogens and Immunological Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration

Rosemary Johann-Liang, MD is a member of the following medical societies: American Academy of Pediatrics, American Medical Association, and Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Veronica A Mas Casullo, MD Assistant Professor, Department of Pediatric Infectious Diseases, Mount Sinai School of Medicine

Disclosure: Nothing to disclose.

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Deer mouse, Peromyscus maniculatus. Courtesy of the Centers for Disease Control and Prevention.
Transmission electron micrograph of Sin Nombre virus. Courtesy of the Centers for Disease Control and Prevention.
Centers for Disease Control and Prevention: Cumulative case count of Hantavirus pulmonary syndrome in the United States per state, valid as of December 31, 2013. Courtesy of the Centers for Disease Control and Prevention.
Characteristics of 465 Hantavirus pulmonary syndrome cases in the United States, March 26, 2007. Courtesy of the Centers for Disease Control and Prevention.
Histopathology of the lung in Hantavirus pulmonary syndrome. Courtesy of the Centers for Disease Control and Prevention.
Table 1. Hantaviruses That Cause HFRS, Rodent Hosts and Geographic Distribution
Hantavirus TypeRodent HostGeographic Distribution
HantaanApodemus agrarius (striped field mouse)Far East, Russia, Northern Asia, Balkans
DobravaApodemus flavicollis (yellow-necked field mouse)Balkans
SeoulRattus norvegicus (urban rats)Worldwide
PuumalaClathrionomys glariolus (bank vole)Europe, Scandinavia, Western Russia
Table 2. Hantavirus Pulmonary Syndrome Virus Types, Rodent Hosts, and Distribution in the United States
Hantavirus TypeRodent HostGeographic Distribution of the Rodent Host in the United States
Sin Nombre virus, monongahela virusDeer mouse, P maniculatusThroughout the United States, except the Southeast and Atlantic seaboard
Bayou virusRice rat, Oryzomys palustrisSoutheastern United States
Black Creek Canal virusCotton rat, Sigmodon hispidusSoutheastern United States
New York-1 virusWhite-footed mouse, Peromyscus leucopusSouthern New England, mid-Atlantic states, Southern states, and Midwest
Table 3. Hantavirus Types, Rodent Hosts, and Geographic Distribution in the Western Hemisphere (other than the United States)
Hantavirus TypeRodent HostGeographic Distribution
AndesOligoryzomys longicaudatusArgentina and Chile
OranO longicaudatusNorthwest Argentina
LechiguanasOligoryzomys flavescensCentral Argentina
Hu39694UnknownCentral Argentina
Laguna NegraCalomys lauchaParaguay and Bolivia
JuquitibaUnknownBrazil
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