Pediatric Herpes Simplex Virus Infection Differential Diagnoses

  • Author: Swetha G Pinninti, MD; Chief Editor: Russell W Steele, MD   more...
 
Updated: Mar 5, 2012
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Swetha G Pinninti, MD  Fellow in Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham School of Medicine

Swetha G Pinninti, MD is a member of the following medical societies: American Academy of Pediatrics, Infectious Diseases Society of America, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Coauthor(s)

Robert W Tolan Jr, MD  Chief, Division of Allergy, Immunology and Infectious Diseases, The Children's Hospital at Saint Peter's University Hospital; Clinical Associate Professor of Pediatrics, Drexel University College of Medicine

Robert W Tolan Jr, MD is a member of the following medical societies: American Academy of Pediatrics, American Medical Association, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Phi Beta Kappa, and Physicians for Social Responsibility

Disclosure: Novartis Honoraria Speaking and teaching

Specialty Editor Board

Leonard R Krilov, MD  Chief of Pediatric Infectious Diseases and International Adoption, Vice Chair, Department of Pediatrics, Professor of Pediatrics, Winthrop University Hospital

Leonard R Krilov, MD is a member of the following medical societies: American Academy of Pediatrics, American Pediatric Society, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, and Society for Pediatric Research

Disclosure: Medimmune Grant/research funds Cliinical trials; Medimmune Honoraria Speaking and teaching; Medimmune Consulting fee Consulting

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Mark R Schleiss, MD  American Legion Chair of Pediatrics, Professor of Pediatrics, Division Director, Division of Infectious Diseases and Immunology, Department of Pediatrics, University of Minnesota Medical School

Mark R Schleiss, MD is a member of the following medical societies: American Pediatric Society, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Robert W Tolan Jr, MD  Chief, Division of Allergy, Immunology and Infectious Diseases, The Children's Hospital at Saint Peter's University Hospital; Clinical Associate Professor of Pediatrics, Drexel University College of Medicine

Robert W Tolan Jr, MD is a member of the following medical societies: American Academy of Pediatrics, American Medical Association, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Phi Beta Kappa, and Physicians for Social Responsibility

Disclosure: Novartis Honoraria Speaking and teaching

Chief Editor

Russell W Steele, MD  Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association

Disclosure: Nothing to disclose.

Additional Contributors

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous author Sherman Alter, MD, to the original writing and development of this article.

References

  1. Richter ER, Dias JK, Gilbert JE 2nd, Atherton SS. Distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck. J Infect Dis. Dec 15 2009;200(12):1901-6. [Medline].

  2. Corey L, Wald A. Maternal and neonatal herpes simplex virus infections. N Engl J Med. Oct 1 2009;361(14):1376-85. [Medline].

  3. Arvin AM, Whitley RJ, Gutierrez KM. Herpes Simplex Virus Infections. In: Remington JS, Klein JO, Wilson CB, Baker CJ, eds. Infectious Diseases of the Fetus and Newborn Infant. 6th ed. Philadelphia, PA: Elsevier Saunders; 2006:845-65.

  4. Charles G Prober. Herpes Simplex Virus. In: Long SS, Pickering LK, Prober CG. Principles and practice of pediatric infectious diseases. 3rd ed. Chuchill Livingston-Saunders; 2008:1012-1021.

  5. Freeman ML, Sheridan BS, Bonneau RH, Hendricks RL. Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. J Immunol. Jul 1 2007;179(1):322-8. [Medline].

  6. Ichihashi M, Nagai H, Matsunaga K. Sunlight is an important causative factor of recurrent herpes simplex. Cutis. Nov 2004;74(5 Suppl):14-8. [Medline].

  7. Peng T, Zhu J, Klock A, et al. Evasion of the mucosal innate immune system by herpes simplex virus type 2. J Virol. Dec 2009;83(23):12559-68. [Medline].

  8. Kohl S. Role of antibody-dependent cellular cytotoxicity in neonatal infection with herpes simplex virus. Rev Infect Dis. Nov-Dec 1991;13 Suppl 11:S950-2. [Medline].

  9. Armstrong GL, Schillinger J, Markowitz L, Nahmias AJ, Johnson RE, McQuillan GM. Incidence of herpes simplex virus type 2 infection in the United States. Am J Epidemiol. May 1 2001;153(9):912-20. [Medline].

  10. Leone P, Fleming DT, Gilsenan AW, Li L, Justus S. Seroprevalence of herpes simplex virus-2 in suburban primary care offices in the United States. Sex Transm Dis. May 2004;31(5):311-6. [Medline].

  11. Xu F, Markowitz LE, Gottlieb SL, Berman SM. Seroprevalence of herpes simplex virus types 1 and 2 in pregnant women in the United States. Am J Obstet Gynecol. Jan 2007;196(1):43.e1-6. [Medline].

  12. Brown ZA, Selke S, Zeh J, et al. The acquisition of herpes simplex virus during pregnancy. N Engl J Med. Aug 21 1997;337(8):509-15. [Medline].

  13. Gardella C, Brown Z, Wald A, et al. Risk factors for herpes simplex virus transmission to pregnant women: a couples study. Am J Obstet Gynecol. Dec 2005;193(6):1891-9. [Medline].

  14. Weiss H. Epidemiology of herpes simplex virus type 2 infection in the developing world. Herpes. Apr 2004;11 Suppl 1:24A-35A. [Medline].

  15. Paz-Bailey G, Ramaswamy M, Hawkes SJ, Geretti AM. Herpes simplex virus type 2: epidemiology and management options in developing countries. Sex Transm Infect. Feb 2007;83(1):16-22. [Medline].

  16. Celum C, Levine R, Weaver M, Wald A. Genital herpes and human immunodeficiency virus: double trouble. Bull World Health Organ. Jun 2004;82(6):447-53. [Medline].

  17. Reynolds SJ. Role of HSV-2 suppressive therapy for HIV prevention. Future Microbiol. Nov 2009;4:1095-7. [Medline].

  18. Zariffard MR, Saifuddin M, Finnegan A, Spear GT. HSV type 2 infection increases HIV DNA detection in vaginal tissue of mice expressing human CD4 and CCR5. AIDS Res Hum Retroviruses. Nov 2009;25(11):1157-64. [Medline].

  19. Kane CT, Diawara S, Ndiaye HD, et al. Concentrated and linked epidemics of both HSV-2 and HIV-1/HIV-2 infections in Senegal: public health impacts of the spread of HIV. Int J STD AIDS. Nov 2009;20(11):793-6. [Medline].

  20. Bernstein DI, Lovett MA, Bryson YJ. Serologic analysis of first-episode nonprimary genital herpes simplex virus infection. Presence of type 2 antibody in acute serum samples. Am J Med. Dec 1984;77(6):1055-60. [Medline].

  21. Brown ZA, Gardella C, Wald A, Morrow RA, Corey L. Genital herpes complicating pregnancy. Obstet Gynecol. Oct 2005;106(4):845-56. [Medline].

  22. Flagg EW, Weinstock H. Incidence of neonatal herpes simplex virus infections in the United States, 2006. Pediatrics. Jan 2011;127(1):e1-8. [Medline].

  23. Ambroggio L, Lorch SA, Mohamad Z, Mossey J, Shah SS. Congenital anomalies and resource utilization in neonates infected with herpes simplex virus. Sex Transm Dis. Nov 2009;36(11):680-5. [Medline].

  24. Armstrong GL, Schillinger J, Markowitz L, Nahmias AJ, Johnson RE, McQuillan GM. Incidence of herpes simplex virus type 2 infection in the United States. Am J Epidemiol. May 1 2001;153(9):912-20. [Medline].

  25. Smith JS, Robinson NJ. Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review. J Infect Dis. Oct 15 2002;186 Suppl 1:S3-28. [Medline].

  26. Dye DW, Simmons GT. Fatal Herpes Virus Type I Infection in a Newborn. Am J Forensic Med Pathol. Nov 24 2009;[Medline].

  27. Malvy D, Ezzedine K, Lancon F, et al. Epidemiology of orofacial herpes simplex virus infections in the general population in France: results of the HERPIMAX study. J Eur Acad Dermatol Venereol. Nov 2007;21(10):1398-403. [Medline].

  28. Arduino PG, Porter SR. Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features. J Oral Pathol Med. Feb 2008;37(2):107-21. [Medline].

  29. Johnston C, Magaret A, Selke S, Remington M, Corey L, Wald A. Herpes simplex virus viremia during primary genital infection. J Infect Dis. Jul 1 2008;198(1):31-4. [Medline].

  30. Wald A, Zeh J, Selke S, Ashley RL, Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med. Sep 21 1995;333(12):770-5. [Medline].

  31. Schiffer JT, Corey L. New concepts in understanding genital herpes. Curr Infect Dis Rep. Nov 2009;11(6):457-64. [Medline].

  32. Koch LH, Fisher RG, Chen C, Foster MM, Bass WT, Williams JV. Congenital herpes simplex virus infection: two unique cutaneous presentations associated with probable intrauterine transmission. J Am Acad Dermatol. Feb 2009;60(2):312-5. [Medline].

  33. Marquez L, Levy ML, Munoz FM, Palazzi DL. A report of three cases and review of intrauterine herpes simplex virus infection. Pediatr Infect Dis J. Feb 2011;30(2):153-7. [Medline].

  34. Kimberlin DW. Herpes simplex virus infections in neonates and early childhood. Semin Pediatr Infect Dis. Oct 2005;16(4):271-81. [Medline].

  35. Kimberlin DW. Herpes simplex virus infections of the newborn. Semin Perinatol. Feb 2007;31(1):19-25. [Medline].

  36. Kimberlin DW, Whitley RJ. Neonatal herpes: what have we learned. Semin Pediatr Infect Dis. Jan 2005;16(1):7-16. [Medline].

  37. Kimberlin D. Herpes simplex virus, meningitis and encephalitis in neonates. Herpes. Jun 2004;11 Suppl 2:65A-76A. [Medline].

  38. Jacobs RF. Neonatal herpes simplex virus infections. Semin Perinatol. Feb 1998;22(1):64-71. [Medline].

  39. Johnson RT. Acute encephalitis. Clin Infect Dis. Aug 1996;23(2):219-224; quiz 225-6. [Medline].

  40. Whitley RJ, Gnann JW. Viral encephalitis: familiar infections and emerging pathogens. Lancet. Feb 9 2002;359(9305):507-13. [Medline].

  41. Whitley RJ, Kimberlin DW. Viral encephalitis. Pediatr Rev. Jun 1999;20(6):192-8. [Medline].

  42. Herget GW, Riede UN, Schmitt-Graff A, et al. Generalized herpes simplex virus infection in an immunocompromised patient--report of a case and review of the literature. Pathol Res Pract. 2005;201(2):123-9. [Medline].

  43. Simoons-Smit AM, Kraan EM, Beishuizen A, Strack van Schijndel RJ, Vandenbroucke-Grauls CM. Herpes simplex virus type 1 and respiratory disease in critically-ill patients: Real pathogen or innocent bystander?. Clin Microbiol Infect. Nov 2006;12(11):1050-9. [Medline].

  44. Wu IB, Schwartz RA. Herpetic whitlow. Cutis. Mar 2007;79(3):193-6. [Medline].

  45. Anderson BJ. The epidemiology and clinical analysis of several outbreaks of herpes gladiatorum. Med Sci Sports Exerc. Nov 2003;35(11):1809-14. [Medline].

  46. Souza PM, Holland EJ, Huang AJ. Bilateral herpetic keratoconjunctivitis. Ophthalmology. Mar 2003;110(3):493-6. [Medline].

  47. Dylewski JS, Bekhor S. Mollaret's meningitis caused by herpes simplex virus type 2: case report and literature review. Eur J Clin Microbiol Infect Dis. Jul 2004;23(7):560-2. [Medline].

  48. Ayangco L, Sheridan PJ, Rogers RS. Erythema multiforme secondary to herpes simplex infection: a case report. J Periodontol. Jul 2001;72(7):953-7. [Medline].

  49. Whitley RJ. Herpes Simplex Virus in Children. Curr Treat Options Neurol. May 2002;4(3):231-237. [Medline].

  50. Sen P, Barton SE. Genital herpes and its management. BMJ. May 19 2007;334(7602):1048-52. [Medline].

  51. Kimberlin DW, Lakeman FD, Arvin AM, Prober CG, Corey L, Powell DA. Application of the polymerase chain reaction to the diagnosis and management of neonatal herpes simplex virus disease. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. J Infect Dis. Dec 1996;174(6):1162-7. [Medline].

  52. Golden WC. Polymerase chain reaction in neonatal HSV encephalitis: an assay to count on?. J Perinatol. Apr 2009;29(4):259-61. [Medline].

  53. Kimberlin DW. Diagnosis of herpes simplex virus in the era of polymerase chain reaction. Pediatr Infect Dis J. Sep 2006;25(9):841-2. [Medline].

  54. Herpes Simplex. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS. Red Book. 28th ed. American academy of Pediatrics; 2009:363-373.

  55. Jones CA, Walker KS, Badawi N. Antiviral agents for treatment of herpes simplex virus infection in neonates. Cochrane Database Syst Rev. Jul 8 2009;CD004206. [Medline].

  56. Gardella C, Brown ZA. Managing genital herpes infections in pregnancy. Cleve Clin J Med. Mar 2007;74(3):217-24. [Medline].

  57. Kimberlin DW, Lin CY, Jacobs RF, et al. Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics. Aug 2001;108(2):230-8. [Medline].

  58. Shah SS, Aronson PL, Mohamad Z, Lorch SA. Delayed acyclovir therapy and death among neonates with herpes simplex virus infection. Pediatrics. Dec 2011;128(6):1153-60. [Medline].

  59. Corey L, Wald A, Patel R, et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med. Jan 1 2004;350(1):11-20. [Medline].

  60. Wald A. New therapies and prevention strategies for genital herpes. Clin Infect Dis. Jan 1999;28 Suppl 1:S4-13. [Medline].

  61. Randolph AG, Washington AE, Prober CG. Cesarean delivery for women presenting with genital herpes lesions. Efficacy, risks, and costs. JAMA. Jul 7 1993;270(1):77-82. [Medline].

  62. [Guideline] ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. No. 82 June 2007. Management of herpes in pregnancy. Obstet Gynecol. Jun 2007;109(6):1489-98. [Medline].

  63. Money D, Steben M,. Guidelines for the management of herpes simplex virus in pregnancy. J Obstet Gynaecol Can. Jun 2008;30(6):514-26. [Medline].

  64. Baker DA. Consequences of herpes simplex virus in pregnancy and their prevention. Curr Opin Infect Dis. Feb 2007;20(1):73-6. [Medline].

  65. [Guideline] U.S. Preventive Services Task Force (USPSTF). Screening for genital herpes: Recommendation statement. Agency for Healthcare Research and Quality (AHRQ). 2005.

  66. Pinninti SG, Angara R, Feja KN, Kimberlin DW, Leach CT, Conrad DA, et al. Neonatal Herpes Disease following Maternal Antenatal Antiviral Suppressive Therapy: A Multicenter Case Series. J Pediatr. Feb 14 2012;[Medline].

  67. Kimberlin D, Powell D, Gruber W, et al. Administration of oral acyclovir suppressive therapy after neonatal herpes simplex virus disease limited to the skin, eyes and mouth: results of a phase I/II trial. Pediatr Infect Dis J. Mar 1996;15(3):247-54. [Medline].

  68. Kimberlin DW, Whitley RJ, Wan W, et al. Oral acyclovir suppression and neurodevelopment after neonatal herpes. N Engl J Med. Oct 6 2011;365(14):1284-92. [Medline].

  69. Martin ET, Krantz E, Gottlieb SL, Magaret AS, Langenberg A, Stanberry L. A pooled analysis of the effect of condoms in preventing HSV-2 acquisition. Arch Intern Med. Jul 13 2009;169(13):1233-40. [Medline].

  70. Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA. Aug 25 2010;304(8):859-66. [Medline].

  71. Mills JL, Carter TC. Acyclovir exposure and birth defects: an important advance, but more are needed. JAMA. Aug 25 2010;304(8):905-6. [Medline].

 
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Primary herpes simplex virus (HSV) gingivostomatitis in an infant is shown. This same patient also had concomitant herpes whitlow as shown in Media file 2.
Herpes whitlow in an infant.
Cutaneous herpes simplex virus (HSV) lesions in a child in whom sexual abuse is suspected.
Vesicular scalp lesions caused by herpes simplex virus (HSV) in a 7-day-old infant.
Herpes gladiatorum in an adolescent wrestler.
MRI shows abnormal signal intensity in the left temporal lobe of an 18-year-old man with herpes simplex virus (HSV) encephalitis.
 
 
 
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