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Kawasaki Disease Treatment & Management

  • Author: Noah S Scheinfeld, JD, MD, FAAD; Chief Editor: Russell W Steele, MD  more...
 
Updated: Sep 13, 2015
 

Approach Considerations

The principal goal of treatment for Kawasaki disease is to prevent coronary artery disease and to relieve symptoms. Full doses of intravenous immunoglobulin (IVIG) are the mainstay of treatment.[5, 8, 9]

Admit all patients to the hospital for administration of IVIG and for observation until fever is controlled. Closely monitor cardiovascular function. Once the fever resolves, clinically significant heart failure or myocardial dysfunction is unlikely.

Aspirin has traditionally been part of the standard treatment of this disorder. Although some authors have suggested that aspirin is no longer needed, most experts use high-dose aspirin for a variable period, followed by lower-dose aspirin for its antiplatelet effects. Aspirin is used in patients with small coronary artery aneurysms (CAAs). Dipyridamole is indicated in patients with larger CAAs.

The appropriate treatment of patients who fail to respond to IVIG remains unclear. Severe Kawasaki disease that is resistant to IVIG may benefit from intravenous pulse corticosteroid therapy or infliximab infusion.

Transfer patients with suspected Kawasaki disease to a facility that has clinicians experienced in the care of these patients and a pediatric or adult cardiologist to evaluate the echocardiogram. Some authorities recommend transferring patients who have documented coronary artery aneurysms to a tertiary pediatric facility.

Guidelines

The following clinical guidelines are relevant for management of Kawasaki disease:

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Emergency Department Care

Any young child who presents to the emergency department (ED) with symptoms of early or acute-stage Kawasaki disease should be evaluated to rule out sepsis or meningitis. Although the diagnosis may seem obvious, other life-threatening diseases must be ruled out. The ED physician must consider the possibility that a child has an incomplete case and proceed with the evaluation listed above. Intravenous access and cardiac monitoring should be established.

Depending on the institution, anti-inflammatory therapy may need to begin in the ED. Arrangements for admission must take into consideration the potential for multiple problems. This is not a routine pediatric illness. Accordingly, transferring the patient to a pediatric referral center may be prudent.

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Intravenous Immunoglobulin

IVIG relieves acute inflammation and has been shown to reduce the rate of coronary aneurysms from greater than 25% in untreated patients to 1-5% in treated patients. Maximal benefits are seen when IVIG is given within the first 10 days of the illness. Some controversy exists about the ideal time to begin IVIG, but it is given most often from days 5-7.

In the past, IVIG was given as a lower dose over 4 days (400 mg/kg/day), but newer studies have shown that high single doses are more effective. In current practice, the dose is 2 g/kg intravenously over 10-12 hours.[17]

In patients in whom the standard treatment fails (approximately 10-15%) and who continue to have fever 36 hours after the initial dose of IVIG, a second treatment with IVIG at the original dose is recommended.[84] A small subgroup of patients fails to respond to a second dose of IVIG.

A study in an ethnically diverse population in San Diego, California, found that patients with IVIG resistance tended to have higher percent bands; higher concentrations of C-reactive protein, alanine aminotransferase, and gamma-glutamyl transferase; lower platelet counts; and lower age-adjusted hemoglobin concentrations. They were also more likely to have aneurysms. However, a proposed scoring system to predict IVIG resistance proved insufficiently accurate to be clinically useful.[85]

In a review from Singapore by Sittiwangkul et al, initial treatment with IVIG (2 g/kg) failed to elicit a response in 13% of patients.[86] The diagnosis in 2 patients with IVIG-resistant Kawasaki disease was delayed, and giant aneurysms developed. Patients with a high erythrocyte sedimentation rate (ESR) were at an increased risk of IVIG-resistant Kawasaki disease. Patients with IVIG-resistant Kawasaki disease had a higher prevalence of coronary artery lesions at the acute phase and 2 months after onset.[86]

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Treatment of IVIG-Resistant Disease

Patients in whom a second dose of IVIG therapy fails can be treated with corticosteroids. Intravenous pulse methylprednisolone may be given at 30 mg/kg for 2-3 hours administered once daily for 1-3 days.

An alternative treatment is infliximab (Remicade) at 5 mg/kg, which is a chimeric mouse-human monoclonal antibody directed against soluble and membrane bound tumor necrosis factor-alpha.[17] Several studies have found infliximab to be useful in treating Kawasaki disease that is refractory to IVIG.[87, 88] Burns et al reported that infliximab was as effective as a second dose of IVIG in patients who did not respond to a first dose of IVIG.[89]

43 patients with KD who were initially treatment resistant to intravenous immunoglobulin (IVIG) had researchers randomized the 43 to get  either a first does infliximab (n=11) or second dose of IVIG (n=32).  IVIG retreatment gave 65.6% (21) patients a response while infliximab gave 90.9% (10)patients aresponse. Infliximab provided less days of hospitalization and a shorter duration of fever.  Adverse events and coronary artery meterics resembled each other in the two groups.[90]

Other alternative therapies for resistant cases include cyclophosphamide with and without methotrexate; however, the effectiveness of these latter treatments is still uncertain because they have been used in only a small number of cases.[17] The following are adjunctive therapies for patients who do not respond to conventional therapies.

Ulinastatin is a human trypsin inhibitor purified from human urine. It has been used only in Japan for refractory cases of Kawasaki disease and is believed to function by inhibiting neutrophil elastase and prostaglandin H2 synthase at the mRNA level.

In the future, by identifying a genetic signature for this group, more aggressive therapies, such as anticytokine therapy, plasmapheresis, or cyclosporin A, may be used to reduce the risk of coronary complications.[43, 33]

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Aspirin

Aspirin has a synergistic effect with IVIG and has long been a standard part of therapy for Kawasaki disease. However, its use has been called into question. Some studies suggest that high- or medium-dose aspirin may have no effect on the response rate to IVIG, duration of fever, or incidence of coronary artery aneurysms despite treatment before or after 5 days of therapy.

Randomized controlled trial outcomes are insufficient to indicate whether children with this disorder should continue to receive salicylate as part of the treatment regimen.[91] Baumer et al concluded that no randomized clinical trials of adequate quality have been performed and that current evidence is insufficient to support the use of salicylate in children with Kawasaki disease as part of their treatment regimen.[92]

Nevertheless, most experts use high-dose aspirin for a variable period, followed by lower-dose aspirin for its antiplatelet effects. High-dose aspirin (80-100 mg/kg/d orally in 4 divided doses) is given in the acute phase for its anti-inflammatory effects. It is continued until day 14 of the illness or until the patient has been afebrile for 48-72 hours.

Once the patient has remained afebrile for 48-72 hours, low-dose aspirin is initiated for its antiplatelet activity. The dose is 3-5 mg/kg/day for a total of 6-8 weeks as long as the patient shows no evidence of coronary abnormalities. For patients who have aneurysms, aspirin should be continued until the aneurysm resolves or should be continued indefinitely.

Patients who remain on long-term, low-dose aspirin should receive an annual influenza vaccine. Additionally, the risks of developing Reye syndrome during an active infection with influenza or varicella should be addressed.

The pediatrician or cardiologist who provides the long-term care monitors aspirin therapy and decides whether to use warfarin or heparin.

Patients on prolonged aspirin therapy must be instructed that concomitant use of ibuprofen antagonizes the irreversible effect of platelet inhibition by aspirin and should be avoided during therapy. Contact activities or high-impact sports should be avoided in patients on prolonged antiplatelet therapy.

Clopidogrel (Plavix) may be briefly substituted for aspirin in patients who develop influenza or varicella. This agent can also be used in patients allergic to aspirin.[17]

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Other Adjunctive Agents

In addition to their use in treatment of IVIG-resistant Kawasaki disease, corticosteroids have been proposed as part of primary therapy. This indication is controversial, however. Research results have been inconsistent, as follows:

  • In a multicenter prospective randomized trial in Japan, the combination of corticosteroids and IVIG significantly decreased coronary artery abnormalities, duration of fever, C-reactive protein levels, and initial treatment failure [93]
  • A randomized trial in the United States in which a single pulsed dose of methylprednisolone (30 mg/kg) was added to conventional therapy saw a reduction in the ESR at 1 week, but no difference in coronary artery abnormalities [94]
  • In a meta-analysis of 4 studies and 447 patients, Athappan et al concluded that the addition of steroids to standard therapy with IVIG and aspirin decreased the rate of re-treatment but did not decrease the incidence of coronary aneurysms or adverse events [95]

The roles of other adjunctive therapies, including pentoxifylline and abciximab, have not yet been definitively determined. Pentoxifylline acts as an anti-inflammatory agent by inhibiting tumor necrosis factor-alpha and may reduce the incidence of aneurysms. Abciximab is a platelet glycoprotein IIb/IIIa receptor inhibitor and has been used in conjunction with standard therapies in patients with Kawasaki disease and giant aneurysms.

Clinical Trials

A selection of ongoing, recruiting, and completed clinical trials is as follows:

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Consultations

Consultation with a pediatric cardiologist may be required if coronary artery aneurysms are identified or if other cardiac complications develop. Consult a pediatric or adult cardiologist for the following:

  • Children or adults with clinically significant coronary artery disease
  • Determining the appropriate timing of subsequent echocardiographic studies
  • Anticoagulation in patients with large aneurysms
  • To determine whether other studies to assess cardiac function (eg, stress testing, coronary artery angiography) are required

Consult a pediatric or adult infectious disease specialist to rule out infectious disease as a cause of fever. Consult a pediatric or adult rheumatologist to rule out other causes of vasculitis and connective tissue diseases. Consult a pediatric dermatologist to rule out other conditions that can manifest with fever and a rash. Pediatric cardiothoracic surgery assistance may be needed in the pediatric ICU for those patients who need bypass surgery.

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Long-Term Monitoring

Reevaluate all patients within 1 week of hospital discharge. Schedule the patient for repeat echocardiography 21-28 days after the onset of fever. If baseline echocardiographic studies and those obtained at 3-4 weeks do not show any evidence of coronary aneurysms, further echocardiography is usually unnecessary, as are activity restrictions or medications beyond 3 months after the initial illness. However, a repeat echocardiogram at 1 year and a cardiovascular risk assessment at 5-year intervals are optimal.

Ensure that a patient with coronary artery aneurysms (CAAs) or other cardiac abnormalities receives further care, as dictated by a cardiologist. Although 55% of patients who have identified coronary lesions during the acute phase of the disease typically show regression or reduction in these lesions within 1-2 years, these patients may still be at an increased risk for future atherosclerotic lesions.

Patients who develop coronary aneurysms should remain on aspirin therapy at least until the abnormalities resolve. Depending on the severity of the aneurysm, the patient will need biannual echocardiography, a cardiac stress test, a risk assessment with lipid evaluation, and possibly an angiogram if noninvasive tests suggest ischemia.

Cardiac stress testing is typically performed 1-5 years after the illness resolves in patients who had CAAs. It is used to assess the existence and functional consequences of coronary artery disease, and helps determine recommendations for physical activity.[33]

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Contributor Information and Disclosures
Author

Noah S Scheinfeld, JD, MD, FAAD Assistant Clinical Professor, Department of Dermatology, Weil Cornell Medical College; Consulting Staff, Department of Dermatology, St Luke's Roosevelt Hospital Center, Beth Israel Medical Center, New York Eye and Ear Infirmary; Assistant Attending Dermatologist, New York Presbyterian Hospital; Assistant Attending Dermatologist, Lenox Hill Hospital, North Shore-LIJ Health System; Private Practice

Noah S Scheinfeld, JD, MD, FAAD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Abbvie<br/>Received income in an amount equal to or greater than $250 from: Optigenex<br/>Received salary from Optigenex for employment.

Coauthor(s)

Steven J Parrillo, DO, FACOEP, FACEP Clinical Adjunct Professor, Medical Director and Faculty, Disaster Medicine and Management Masters Program, Philadelphia University College of Health Sciences; Associate Professor, Clinical and Educational Scholarship Track, Jefferson Medical College of Thomas Jefferson University; Director, Division of EMS and Disaster Medicine, Albert Einstein Healthcare Network

Steven J Parrillo, DO, FACOEP, FACEP is a member of the following medical societies: American College of Emergency Physicians, American College of Osteopathic Emergency Physicians, American Osteopathic Association, World Association for Disaster and Emergency Medicine

Disclosure: Nothing to disclose.

Paul R Ogershok, MD Allergist, Allergy, Asthma, and Immunology Clinic, Southwest Regional Medical Center

Paul R Ogershok, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American College of Allergy, Asthma and Immunology, Pennsylvania Medical Society, West Virginia State Medical Association

Disclosure: Nothing to disclose.

Elena L Jones, MD Clinical Assistant Professor of Dermatology, Columbia University College of Physicians and Surgeons; Clinic Chief, Department of Dermatology, St Luke's-Roosevelt Hospital Center

Disclosure: Nothing to disclose.

Chief Editor

Russell W Steele, MD Clinical Professor, Tulane University School of Medicine; Staff Physician, Ochsner Clinic Foundation

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, Southern Medical Association

Disclosure: Nothing to disclose.

Acknowledgements

Jeffrey Glenn Bowman, MD, MS Consulting Staff, Highfield MRI, Columbus, Ohio

Disclosure: Nothing to disclose.

Lawrence H Brent, MD Associate Professor of Medicine, Jefferson Medical College of Thomas Jefferson University; Chair, Program Director, Department of Medicine, Division of Rheumatology, Albert Einstein Medical Center

Lawrence H Brent, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Immunologists, American College of Physicians, and American College of Rheumatology

Disclosure: Genentech Honoraria Speaking and teaching; Genentech Grant/research funds Other; Amgen Honoraria Speaking and teaching; Pfizer Honoraria Speaking and teaching; Abbott Immunology Honoraria Speaking and teaching; Takeda Honoraria Speaking and teaching; UCB Speaking and teaching; Omnicare Consulting fee Consulting; Centocor Consulting fee Consulting

Herbert S Diamond, MD Professor of Medicine, Temple University School of Medicine; Chairman Emeritus, Department of Internal Medicine, Western Pennsylvania Hospital

Herbert S Diamond, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American College of Rheumatology, American Medical Association, and Phi Beta Kappa

Disclosure: Merck Ownership interest Other; Smith Kline Ownership interest Other; Zimmer Ownership interest Other

Joseph Domachowske, MD Professor of Pediatrics, Microbiology and Immunology, Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University

Joseph Domachowske, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Kristine M Lohr, MD, MS Professor, Department of Internal Medicine, Center for the Advancement of Women's Health and Division of Rheumatology, Director, Rheumatology Training Program, University of Kentucky College of Medicine

Kristine M Lohr, MD, MS is a member of the following medical societies: American College of Physicians and American College of Rheumatology

Disclosure: Nothing to disclose.

Catherine V Parrillo, DO, FACOP, FAAP, Retired, Clinical Assistant Professor, Department of Pediatrics, Philadelphia College of Osteopathic Medicine

Catherine V Parrillo, DO, FACOP, FAAP, is a member of the following medical societies: American Academy of Pediatrics, American College of Osteopathic Pediatricians, and American Osteopathic Association

Disclosure: Nothing to disclose

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Reference Salary Employment

Martin Weisse, MD Program Director, Associate Professor, Department of Pediatrics, West Virginia University

Martin Weisse, MD is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Grace M Young, MD Associate Professor, Department of Pediatrics, University of Maryland Medical Center

Grace M Young, MD is a member of the following medical societies: American Academy of Pediatrics and American College of Emergency Physicians

Disclosure: Nothing to disclose.

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Patchy generalized macular erythema, which is also typical of some viral exanthems.
Peeling and erythema of the fingertips.
Strawberry tongue.
Pediatrics, Kawasaki disease. Note the appearance of the hand and lips. Photo courtesy of Sam Richardson, MD.
Clinical manifestations and time course of Kawasaki disease.
Oral manifestations of Kawasaki disease: red lips and strawberry tongue.
 
 
 
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