Legionella Infection Differential Diagnoses

  • Author: Mobeen H Rathore, MD, CPE, FAAP, FIDSA; Chief Editor: Russell W Steele, MD   more...
 
Updated: Oct 25, 2011
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Mobeen H Rathore, MD, CPE, FAAP, FIDSA  Chief of Division of Pediatric Infectious Diseases/Immunology, Associate Chairman of Department of Pediatrics, University of Florida College of Medicine at Jacksonville; Hospital Epidemiologist and Section Chief of Infectious Disease and Immunology, Wolfson Children's Hospital; Director of University of Florida Center for HIV/AIDS Research, Education and Service (UF CARES)

Mobeen H Rathore, MD, CPE, FAAP, FIDSA is a member of the following medical societies: American Academy of Pediatrics, American Society for Microbiology, European Society for Paediatric Infectious Diseases, Florida Medical Association, Florida Pediatric Society, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Society for Healthcare Epidemiology of America, Society for Pediatric Research, Southern Medical Association, and Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Coauthor(s)

Ana Alvarez, MD  Associate Professor of Pediatrics, Pediatric Infectious Diseases Fellowship Director, University of Florida College of Medicine, Jacksonville

Ana Alvarez, MD is a member of the following medical societies: American Academy of Pediatrics, Florida Medical Association, Infectious Diseases Society of America, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Glenn Fennelly, MD, MPH  Director, Division of Infectious Diseases, Lewis M Fraad Department of Pediatrics, Jacobi Medical Center; Clinical Associate Professor of Pediatrics, Albert Einstein College of Medicine

Glenn Fennelly, MD, MPH is a member of the following medical societies: Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Larry I Lutwick, MD  Professor of Medicine, State University of New York Downstate Medical School; Director, Infectious Diseases, Veterans Affairs New York Harbor Health Care System, Brooklyn Campus

Larry I Lutwick, MD is a member of the following medical societies: American College of Physicians and Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Robert W Tolan Jr, MD  Chief, Division of Allergy, Immunology and Infectious Diseases, The Children's Hospital at Saint Peter's University Hospital; Clinical Associate Professor of Pediatrics, Drexel University College of Medicine

Robert W Tolan Jr, MD is a member of the following medical societies: American Academy of Pediatrics, American Medical Association, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Phi Beta Kappa, and Physicians for Social Responsibility

Disclosure: Novartis Honoraria Speaking and teaching

Chief Editor

Russell W Steele, MD  Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association

Disclosure: Nothing to disclose.

References

  1. American Academy of Pediatrics. Legionella pneumophila infections. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2009:419-20.

  2. Gonzalez AG, Martin JM. Legionella pneumophila serogroup 1 pneumonia recurrence postbone marrow transplantation. Pediatr Infect Dis J. October 2007;26:961-963.

  3. Greenberg D, Chiou CC, Famigilleti R, Lee TC, Yu VL. Problem pathogens: paediatric legionellosis--implications for improved diagnosis. Lancet Infect Dis. Aug 2006;6(8):529-35. [Medline].

  4. Luttichau HR, Vinther C, Uldum SA, et al. An outbreak of Pontiac fever among children following use of a whirlpool. Clin Infect Dis. Jun 1998;26(6):1374-8. [Medline].

  5. Campins M, Ferrer A, Callis L, et al. Nosocomial Legionnaire's disease in a children's hospital. Pediatr Infect Dis J. Mar 2000;19(3):228-34. [Medline].

  6. Johansson PJ, Andersson K, Wiebe T, Schalen C, Bernander S. Nosocomial transmission of Legionella pneumophila to a child from a hospital's cold-water supply. Scand J Infect Dis. 2006;38(11-12):1023-7. [Medline].

  7. Franzin L, Scolfaro C, Cabodi D, et al. Legionella pneumophila pneumonia in a newborn after water birth: a new mode of transmission [case report]. Clin Infect Dis. Nov 1 2001;33(9):e103-4. [Medline].

  8. Thoni A, Zech N, Moroder L, Ploner F. [Water contamination and infection rate after water births]. Gynakol Geburtshilfliche Rundsch. 2007;47(1):33-8. [Medline].

  9. Stone BJ, Abu Kwaik Y. Expression of multiple pili by Legionella pneumophila: identification and characterization of a type IV pilin gene and its role in adherence to mammalian and protozoan cells. Infect Immun. Apr 1998;66(4):1768-75. [Medline].

  10. Rubin LG. Legionella species. In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 3rd ed. Philadelphia, PA: Churchill Livingstone; 2008:912-915.

  11. Myers C, Corbelli R, Schrenzel J, Gervaix A. Multiple pulmonary abscesses caused by Legionella pneumophila infection in an infant with croup. Pediatr Infect Dis J. Aug 2006;25(8):753-4. [Medline].

  12. Heine S, Fuchs A, von Muller L, Krenn T, Nemat S, Graf N. Legionellosis must be kept in mind in case of pneumonia with lung abscesses in children receiving therapeutic steroids. Infection. Oct 2011;39(5):481-4. [Medline].

  13. Monforte R, Marco F, Estruch R, Campo E. Multiple organ involvement by Legionella pneumophila in a fatal case of Legionnaires' disease. J Infect Dis. Apr 1989;159(4):809. [Medline].

  14. American Thoracic Society. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388-416.

  15. Scola BL, Maltezou H. Legionella and Q fever community acquired pneumonia in children. Paediatr Respir Rev. 2004;5 Suppl A:S171-7. [Medline].

  16. Wolf J, Daley AJ. Microbiological aspects of bacterial lower respiratory tract illness in children: atypical pathogens. Paediatr Respir Rev. Sep 2007;8(3):212-9, quiz 219-20. [Medline].

  17. Carlson NC, Kuskie MR, Dobyns EL, et al. Legionellosis in children: an expanding spectrum. Pediatr Infect Dis J. Feb 1990;9(2):133-7. [Medline].

  18. Sopena N, Sabria-Leal M, Pedro-Botet ML, et al. Comparative study of the clinical presentation of Legionella pneumonia and other community-acquired pneumonias. Chest. May 1998;113(5):1195-200. [Medline].

  19. Qin X, Abe PM, Weissman SJ, Manning SC. Extrapulmonary legionella micdadei infection in a previously healthy child. Pediatr Infect Dis J. Dec 2002;21(12):1174-6. [Medline].

  20. Holmberg RE Jr, Pavia AT, Montgomery D, et al. Nosocomial Legionella pneumonia in the neonate. Pediatrics. Sep 1993;92(3):450-3. [Medline].

  21. Shachor-Meyouhas Y, Kassis I, Bamberger E, et al. Fatal hospital-acquired Legionella pneumonia in a neonate. Pediatr Infect Dis J. Mar 2010;29(3):280-1. [Medline].

  22. Tan MJ, Tan JS, Hamor RH, File TM Jr, Breiman RF. The radiologic manifestations of Legionnaire's disease. The Ohio Community-Based Pneumonia Incidence Study Group. Chest. Feb 2000;117(2):398-403. [Medline].

  23. Hodina M, Hanquinet S, Cotting J, et al. Imaging of cavitary necrosis in complicated childhood pneumonia. Eur Radiol. Feb 2002;12(2):391-6. [Medline].

  24. Miller ML, Hayden R, Gaur A. Legionella bozemanii pulmonary abscess in a pediatric allogeneic stem cell transplant recipient. Pediatr Infect Dis J. Aug 2007;26(8):760-2. [Medline].

  25. Famiglietti RF, Bakerman PR, Saubolle MA, Rudinsky M. Cavitary legionellosis in two immunocompetent infants. Pediatrics. Jun 1997;99(6):899-903. [Medline].

  26. Gervaix A, Beghetti M, Rimensberger P, et al. Bullous emphysema after Legionella pneumonia in a two-year-old child. Pediatr Infect Dis J. Jan 2000;19(1):86-7. [Medline].

  27. Sasaki T, Matsumoto N, Nakao H, et al. An outbreak of Legionnaires' disease associated with a circulating bathwater system at a public bathhouse. I: a clinical analysis. J Infect Chemother. Apr 2008;14(2):117-22. [Medline].

  28. Stout JE, Sens K, Mietzner S, et al. Comparative activity of quinolones, macrolides and ketolides against Legionella species using in vitro broth dilution and intracellular susceptibility testing. Int J Antimicrob Agents. Apr 2005;25(4):302-7. [Medline].

  29. Blazquez Garrido RM, Espinosa Parra FJ, Alemany Frances L, et al. Antimicrobial chemotherapy for Legionnaires disease: levofloxacin versus macrolides. Clin Infect Dis. Mar 15 2005;40(6):800-6. [Medline].

  30. Watson AM, Boyce TG, Wylam ME. Legionella pneumonia: infection during immunosuppressive therapy for idiopathic pulmonary hemosiderosis. Pediatr Infect Dis J. Jan 2004;23(1):82-4. [Medline].

  31. Tablan OC, Anderson LJ, Besser R, et al. Guidelines for preventing health-care--associated pneumonia, 2003: Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep. Mar 26 2004;53(RR-3):1-36. [Medline].

  32. Yu VL, Lee TC. Neonatal legionellosis: the tip of the iceberg for pediatric hospital-acquired pneumonia?. Pediatr Infect Dis J. Mar 2010;29(3):282-4. [Medline].

  33. Singh N, Stout JE, Yu VL. Prevention of Legionnaires' disease in transplant recipients: recommendations for a standardized approach. Transpl Infect Dis. Jun 2004;6(2):58-62. [Medline].

 
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