Pediatric Mucormycosis Differential Diagnoses

  • Author: Meera Varman, MD; Chief Editor: Russell W Steele, MD   more...
 
Updated: Aug 25, 2011
 
 

Diagnostic Considerations

The differential diagnoses of mucormycoses vary and depend on specific organ involvement. For rhinocerebral mucormycosis, the differential diagnoses include cavernous sinus thrombosis, bacterial orbital cellulitis, and central nervous system (CNS) aspergillosis.

Differential Diagnoses

Proceed to Workup
 
 
Contributor Information and Disclosures
Author

Meera Varman, MD  Associate Professor, Department of Pediatrics, Section of Pediatric Infectious Diseases, Creighton University Medical Center

Meera Varman, MD is a member of the following medical societies: American Academy of Pediatrics, Infectious Diseases Society of America, and Pediatric Infectious Diseases Society

Disclosure: phamaceutical companies Honoraria Speaking and teaching; phamaceutical companies Grant/research funds clinical trials

Specialty Editor Board

Gary J Noel, MD  Professor, Department of Pediatrics, Weill Cornell Medical College; Attending Pediatrician, New York-Presbyterian Hospital

Gary J Noel, MD is a member of the following medical societies: Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Mark R Schleiss, MD  American Legion Chair of Pediatrics, Professor of Pediatrics, Division Director, Division of Infectious Diseases and Immunology, Department of Pediatrics, University of Minnesota Medical School

Mark R Schleiss, MD is a member of the following medical societies: American Pediatric Society, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Russell W Steele, MD  Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association

Disclosure: Nothing to disclose.

Acknowledgments

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous authors Mary Carmen Y Mancao, MD, Christine A Reyes, MD, and Debra Whaley, MD, to the development and writing of the source article.

References

  1. Richardson M, Koukila-Kahkola P, Shankland G. Rhizopus, Rhizomucor, Absidia, and other agents of systemic and subcutaneous zygomycoses. In: Murray PR, Baron EJ, Jorgensen JH, Pfaller MA , Yolken RH, eds. Manual of Clinical Microbiology. 9th ed. Washington, DC: American Society of Microbiology; 2007.

  2. Sugar A. Agents of mucormycosis and related species. In: Mandell GL, Bennet JE, Dolin R, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Churchill Livingstone; 2009:Chapter 259.

  3. Wiedermann BL. Zygomycosis. In: Feigen RD, Cherry JD, Demmler-Harrison GJ, Kaplan SL, eds. Textbook of Pediatric Infectious Diseases. 6th ed. Philadelphia, Pa: Saunders; 2009.

  4. Frater JL, Hall GS, Procop GW. Histologic features of zygomycosis: emphasis on perineural invasion and fungal morphology. Arch Pathol Lab Med. Mar 2001;125(3):375-8. [Medline].

  5. Simbli M, Hakim F, Koudieh M, Tleyjeh IM. Nosocomial post-traumatic cutaneous mucormycosis: a systematic review. Scand J Infect Dis. 2008;40(6-7):577-82. [Medline].

  6. Robertson AF, Joshi VV, Ellison DA, Cedars JC. Zygomycosis in neonates. Pediatr Infect Dis J. Aug 1997;16(8):812-5. [Medline].

  7. Kline MW. Mucormycosis in children: review of the literature and report of cases. Pediatr Infect Dis. Nov-Dec 1985;4(6):672-6. [Medline].

  8. Garbino J, Myers C, Ambrosioni J, Gumy-Pause F. Report of a successful treatment of pulmonary Cunninghamella bertholletiae infection with liposomal amphotericin and posaconazole in a child with GvHD and review of the literature. J Pediatr Hematol Oncol. Mar 2010;32(2):85-7. [Medline].

  9. Rüping MJ, Heinz WJ, Kindo AJ, Rickerts V, Lass-Flörl C, Beisel C, et al. Forty-one recent cases of invasive zygomycosis from a global clinical registry. J Antimicrob Chemother. Feb 2010;65(2):296-302. [Medline].

  10. Dave SP, Vivero RJ, Roy S. Facial cutaneous mucormycosis in a full-term infant. Arch Otolaryngol Head Neck Surg. Feb 2008;134(2):206-9. [Medline].

  11. Scheinfeld N. A review of the new antifungals: posaconazole, micafungin, and anidulafungin. J Drugs Dermatol. Dec 2007;6(12):1249-51. [Medline].

  12. Ullmann AJ, Lipton JH, Vesole DH, Chandrasekar P, Langston A, Tarantolo SR, et al. Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N Engl J Med. Jan 25 2007;356(4):335-47. [Medline].

  13. Kaide CG, Khandelwal S. Hyperbaric oxygen: applications in infectious disease. Emerg Med Clin North Am. May 2008;26(2):571-95, xi. [Medline]. [Full Text].

  14. Garg PK, Gupta N, Gautam V, Hadke NS. Gastric zygomycosis: unusual cause of gastric perforation in an immunocompetent patient. South Med J. Apr 2008;101(4):449-50. [Medline].

  15. Goel S, Carter JE, Culpepper M, Kahn AG. Primary renal zygomycotic infarction mimicking renal neoplasia in an immunocompetent patient. Am J Med Sci. Oct 2009;338(4):330-3. [Medline].

  16. Kontoyiannis DP, Lionakis MS, Lewis RE, Chamilos G, Healy M, Perego C, et al. Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases. J Infect Dis. Apr 15 2005;191(8):1350-60. [Medline].

  17. Singh N, Aguado JM, Bonatti H, Forrest G, Gupta KL, Safdar N, et al. Zygomycosis in solid organ transplant recipients: a prospective, matched case-control study to assess risks for disease and outcome. J Infect Dis. Sep 15 2009;200(6):1002-11. [Medline].

 
Previous
Next
 
Black eschar on the skin of an immunocompromised patient.
Mucormycosis with broad, aseptate hyphae (hematoxylin and eosin, original magnification ×40).
Angioinvasion (hematoxylin and eosin, original magnification ×10).
Perineural invasion (hematoxylin and eosin, original magnification ×20).
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.