eMedicine Specialties > Pediatrics: General Medicine > Infectious Disease

Sporotrichosis: Follow-up

Author: William P Baugh, MD, Assistant Clinical Professor of Dermatology, University of California Irvine School of Medicine and Western School of Medicine; Medical Director, Full Spectrum Dermatology; Consulting Staff, Department of Dermatology, St Jude Medical Center
Coauthor(s): Brad S Graham, MD, Consulting Staff, Dermatology Associates of Tyler; Cynthia L Chen, Western University of Health Sciences College of Osteopathic Medicine of the Pacific
Contributor Information and Disclosures

Updated: Aug 28, 2009

Follow-up

Further Inpatient Care

  • Sporotrichosis is usually managed on an outpatient basis. A few patients with the more severe forms (eg, disseminated sporotrichosis) may require hospitalization.

Further Outpatient Care

  • The primary therapeutic approach to managing cutaneous lesions of sporotrichosis involves administration of systemic medications to eradicate the fungus. If a cutaneous plaque, nodule, or ulcer is present, consider teaching the patient about supportive local wound care to facilitate healing. Such education typically involves instruction on keeping lesions clean and free from further contamination. If the lesion is ulcerated, a topical ointment may be applied to prevent occurrence of secondary bacterial infections. Follow up with the patient in the clinic every 1-2 weeks to monitor progress. Instruct the patient about potential sources of this fungus to help avoid further infections.

Inpatient & Outpatient Medications

Deterrence/Prevention

  • Educate every patient who has acquired sporotrichosis about the fungus and provide information about how to prevent occurrence of further infections. S schenckii is a saprophytic fungus, usually found in the soil. Instruct patients to be careful when working with soils, sphagnum moss, decaying wood, roses, thorn bushes, and salt marsh or prairie hay. If exposure to these materials or plants is anticipated, instruct patients to wear personal protective equipment, particularly gloves, to minimize thorn or splinter punctures of the skin.
  • Sporotrichosis has also been acquired from pets, particularly cats, so the physician should consider this potential source of acquisition if the aforementioned soil and plant exposures do not apply.

Prognosis

Prognosis for patients with sporotrichosis depends on its clinical type (eg, fixed cutaneous, localized cutaneous, lymphocutaneous, disseminated), associated underlying diseases, and the patient's immune response to this fungus.

  • Patients with fixed cutaneous and lymphocutaneous sporotrichosis have an excellent prognosis. These lesions usually respond well to therapy and typically resolve after 4-6 weeks of therapy.
  • Patients with the osteoarticular form of sporotrichosis usually have a moderately good prognosis, but they may require higher doses of medication, longer courses of therapy to achieve cure, or both.
  • Patients with pulmonary or disseminated forms of sporotrichosis usually have some underlying medical condition or immune deficit that allows the fungus to grow and spread unchecked. For example, patients who have insulin-dependent diabetes mellitus, chronic alcoholism, or AIDS may be unable to mount an adequate immune response to keep this fungal infection localized. Such patients typically have a worse prognosis and require longer courses of therapy.

Patient Education

Miscellaneous

Medicolegal Pitfalls

  • Medicolegal problems associated with clinical cases of sporotrichosis are unusual but may occur for a few basic reasons.
    • Failure to establish the appropriate diagnosis, resulting in delay of care or provision of inappropriate care, may result in litigation.
    • The dome-shaped nature of a cutaneous ulcer produced by sporotrichosis, combined with its abrupt clinical course, may mimic a keratoacanthoma. This may result in an unnecessary surgical procedure or inadvertent use of an injectable chemotherapeutic agent to treat the suspected skin cancer. These procedures only worsen the situation.
    • Failure to provide appropriate treatment or medications is another example of a medicolegal pitfall because resolution of this fungal infection may be delayed, resulting in unnecessary inflammation and scarring.
    • Failure to follow up with the affected patient to assure complete resolution of sporotrichosis may result in recurrence or undue morbidity or mortality. Patients should be scheduled for follow-up after clinical resolution of sporotrichosis to monitor for recurrence.
 


More on Sporotrichosis

Overview: Sporotrichosis
Differential Diagnoses & Workup: Sporotrichosis
Treatment & Medication: Sporotrichosis
Follow-up: Sporotrichosis
Multimedia: Sporotrichosis
References

References

  1. [Guideline] Kauffman CA, Bustamante B, Chapman SW, Pappas PG. Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. Nov 15 2007;45(10):1255-65. [Medline].

  2. Vilela R, Souza GF, Fernandes Cota G, Mendoza L. Cutaneous and meningeal sporotrichosis in a HIV patient. Rev Iberoam Micol. Jun 2007;24(2):161-3. [Medline].

  3. Zhou CH, Asuncion A, Love GL. Laryngeal and respiratory tract sporotrichosis and steroid inhaler use. Arch Pathol Lab Med. Jul 2003;127(7):893-4. [Medline].

  4. Lyon GM, Zurita S, Casquero J, et al. Population-based surveillance and a case-control study of risk factors for endemic lymphocutaneous sporotrichosis in Peru. Clin Infect Dis. Jan 1 2003;36(1):34-9. [Medline].

  5. Leme LR, Schubach TM, Santos IB, et al. Mycological evaluation of bronchoalveolar lavage in cats with respiratory signs from Rio de Janeiro, Brazil. Mycoses. May 2007;50(3):210-4. [Medline].

  6. Feeney KT, Arthur IH, Whittle AJ, Altman SA, Speers DJ. Outbreak of sporotrichosis, Western Australia. Emerg Infect Dis. Aug 2007;13(8):1228-31. [Medline].

  7. Almeida-Paes R, Pimenta MA, Pizzini CV, Monteiro PC, Peralta JM, Nosanchuk JD. Use of mycelial-phase Sporothrix schenckii exoantigens in an enzyme-linked immunosorbent assay for diagnosis of sporotrichosis by antibody detection. Clin Vaccine Immunol. Mar 2007;14(3):244-9. [Medline].

  8. Sharma NL, Mahajan VK, Verma N, Thakur S. Cutaneous sporotrichosis: an unusual clinico-pathologic and therapeutic presentation. Mycoses. Dec 2003;46(11-12):515-8. [Medline].

  9. Bonifaz A, Fierro L, Saul A, Ponce RM. Cutaneous sporotrichosis. Intermittent treatment (pulses) with itraconazole. Eur J Dermatol. Jan-Feb 2008;18(1):61-4. [Medline].

  10. Almeida-Paes R, Pimenta MA, Monteiro PC, Nosanchuk JD, Zancope-Oliveira RM. Immunoglobulins G, M, and A against Sporothrix schenckii exoantigens in patients with sporotrichosis before and during treatment with itraconazole. Clin Vaccine Immunol. Sep 2007;14(9):1149-57. [Medline].

  11. Baroni A, Palla M, Iovene MR, et al. Sporotrichosis: success of itraconazole treatment. Skinmed. Jan-Feb 2007;6(1):41-4. [Medline].

  12. Baum GL, Donnerberg RL, Stewart D. Pulmonary sporotrichosis. N Engl J Med. Feb 20 1969;280(8):410-3. [Medline].

  13. Bonifaz A, Peniche A, Mercadillo P. Successful treatment of AIDS-related disseminated cutaneous sporotrichosis with itraconazole. AIDS Patient Care STDS. Dec 2001;15(12):603-6. [Medline].

  14. Davis BA. Sporotrichosis. Dermatol Clin. Jan 1996;14(1):69-76. [Medline].

  15. De Araujo T, Marques AC, Kerdel F. Sporotrichosis. Int J Dermatol. Dec 2001;40(12):737-42. [Medline].

  16. Dolezal JF. Blastomycoid sporotrichosis. Response to low-dose amphotericin B. J Am Acad Dermatol. May 1981;4(5):523-7. [Medline].

  17. Dunstan RW, Langham RF, Reimann KA. Feline sporotrichosis: a report of five cases with transmission to humans. J Am Acad Dermatol. Jul 1986;15(1):37-45. [Medline].

  18. Gordhan A, Ramdial PK, Morar N. Disseminated cutaneous sporotrichosis: a marker of osteoarticular sporotrichosis masquerading as gout. Int J Dermatol. Nov 2001;40(11):717-9. [Medline].

  19. Hajjeh R, McDonnell S, Reef S. Outbreak of sporotrichosis among tree nursery workers. J Infect Dis. Aug 1997;176(2):499-504. [Medline].

  20. Horii KA, Jackson MA, Sharma V. Localized cutaneous sporotrichosis in a child. Arch Dermatol. Oct 2006;142(10):1369-70. [Medline].

  21. Karakayali G, Lenk N, Alli N. Itraconazole therapy in lymphocutaneous sporotrichosis: a case report and review of the literature. Cutis. Feb 1998;61(2):106-7. [Medline].

  22. Kauffman CA, Pappas PG, McKinsey DS. Treatment of lymphocutaneous and visceral sporotrichosis with fluconazole. Clin Infect Dis. Jan 1996;22(1):46-50. [Medline].

  23. Lynch PJ, Voorhees JJ, Harrell ER. Systemic sporotrichosis. Ann Intern Med. Jul 1970;73(1):23-30. [Medline].

  24. Meffert JJ. Cutaneous sporotrichosis presenting as a keratoacanthoma. Cutis. Jul 1998;62(1):37-9. [Medline].

  25. Mohan N, Jayaseelan E, Abraham A. Cutaneous sporotrichosis in Bangalore, southern India. Int J Dermatol. 43(4):269-72. [Medline].

  26. O'Reilly LC, Altman SA. Macrorestriction analysis of clinical and environmental isolates of Sporothrix schenckii. J Clin Microbiol. Jul 2006;44(7):2547-52. [Medline].

  27. Rodriguez G, Sarmiento L. The asteroid bodies of sporotrichosis. Am J Dermatopathol. Jun 1998;20(3):246-9. [Medline].

  28. Sandhu K, Gupta S. Potassium iodide remains the most effective therapy for cutaneous sporotrichosis. J Dermatolog Treat. Dec 2003;14(4):200-2. [Medline].

  29. Sanz J, Andreu JL, Martinez-Garcia G. Sporotrichial bursitis. Br J Rheumatol. Apr 1998;37(4):461-2. [Medline].

  30. Sharma NL, Mahajan VK, Verma N, Thakur S. Cutaneous sporotrichosis: an unusual clinico-pathologic and therapeutic presentation. Mycoses. Dec 2003;46(11-12):515-8. [Medline].

  31. Ticoras CJ, Schroeter AL, Hornbeck KL. Disseminated ulcerated papules and nodules. Cutaneous disseminated sporotrichosis. Arch Dermatol. Aug 1996;132(8):963-4, 966-7. [Medline].

  32. Ware AJ, Cockerell CJ, Skiest DJ. Disseminated sporotrichosis with extensive cutaneous involvement in a patient with AIDS. J Am Acad Dermatol. Feb 1999;40(2 Pt 2):350-5. [Medline].

  33. Werner AH, Werner BE. Sporotrichosis in man and animal. Int J Dermatol. Oct 1994;33(10):692-700. [Medline].

  34. Whitfeld MJ, Faust HB. Lymphocutaneous sporotrichosis. Australas J Dermatol. Aug 1995;36(3):161-3. [Medline].

  35. Zaharopoulos P. Fine-needle aspiration cytologic diagnosis of lymphocutaneous sporotrichosis: a case report. Diagn Cytopathol. Feb 1999;20(2):74-7. [Medline].

Further Reading

Keywords

Sporothrix schenckii, S schenckii, dimorphic fungal infection, lymphocutaneous sporotrichosis, fixed cutaneous sporotrichosis, disseminated sporotrichosis, Schenck disease, laryngeal and respiratory tract sporotrichosis, cutaneous sporotrichosis, lymphangitic cutaneous sporotrichosis, cellulitic sporotrichosis, mycetomalike sporotrichosis, systemic sporotrichosis, acquired immunodeficiency syndrome, AIDS, erythema nodosum, polyarteritis nodosum, treatment, diagnosis

Contributor Information and Disclosures

Author

William P Baugh, MD, Assistant Clinical Professor of Dermatology, University of California Irvine School of Medicine and Western School of Medicine; Medical Director, Full Spectrum Dermatology; Consulting Staff, Department of Dermatology, St Jude Medical Center
William P Baugh, MD is a member of the following medical societies: American Academy of Dermatology, American Society for Laser Medicine and Surgery, and Christian Medical & Dental Society
Disclosure: Nothing to disclose.

Coauthor(s)

Brad S Graham, MD, Consulting Staff, Dermatology Associates of Tyler
Brad S Graham, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society of Dermatopathology, and Texas Dermatological Society
Disclosure: Nothing to disclose.

Cynthia L Chen, Western University of Health Sciences College of Osteopathic Medicine of the Pacific
Disclosure: Nothing to disclose.

Medical Editor

Gary J Noel, MD, Department of Pediatrics, Clinical Associate Professor, Weill Medical College of Cornell University
Gary J Noel, MD is a member of the following medical societies: Pediatric Infectious Diseases Society
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

Larry I Lutwick, MD, Professor of Medicine, State University of New York, Downstate Medical School; Director, Infectious Diseases, Veterans Affairs New York Harbor Health Care System, Brooklyn Campus
Larry I Lutwick, MD is a member of the following medical societies: American College of Physicians and Infectious Diseases Society of America
Disclosure: Nothing to disclose.

CME Editor

Daniel Rauch, MD, FAAP, Director, Pediatric Hospitalist Program, Associate Professor, Department of Pediatrics, New York University School of Medicine
Daniel Rauch, MD, FAAP is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, and Society of Hospital Medicine
Disclosure: Baxter Honoraria Consulting

Chief Editor

Russell W Steele, MD, Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine
Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association
Disclosure: None None None

 
 
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