Pediatric Syphilis Differential Diagnoses
- Author: Muhammad Waseem, MD; Chief Editor: Russell W Steele, MD more...
Diagnostic Considerations
Diagnostic considerations in patients with possible syphilis include the following:
- Anthrax
- Bejel
- Granuloma inguinale
- Lymphogranuloma venereum
- Pinta
- Rat-bite fever
- Relapsing fever
- Sepsis
- Venereal warts
- Yaws
Differential Diagnoses
- Acropustulosis
- Chorioretinitis
- Enteroviral Infections
- Erythema Toxicum
- Gonorrhea
- Herpes Simplex Virus Infection
- Human Immunodeficiency Virus Infection
- Lyme Disease
- Parvovirus B19 Infection
- Tuberculosis
Centers for Disease Control and Prevention. Congenital syphilis - United States, 2003-2008. MMWR Morb Mortal Wkly Rep. Apr 16 2010;59(14):413-7. [Medline].
Heffelfinger JD, Swint EB, Berman SM, Weinstock HS. Trends in primary and secondary syphilis among men who have sex with men in the United States. Am J Public Health. Jun 2007;97(6):1076-83. [Medline].
Vasquez-Manzanilla O, Dickson-Gonzalez SM, Salas JG, Rodriguez-Morales AJ, Arria M. Congenital syphilis in valera, Venezuela. J Trop Pediatr. Aug 2007;53(4):274-7. [Medline].
Sena AC, Muth SQ, Heffelfinger JD, et al. Factors and the sociosexual network associated with a syphilis outbreak in rural North Carolina. Sex Transm Dis. May 2007;34(5):280-7. [Medline].
Klig JE. Ophthalmologic complications of systemic disease. Emerg Med Clin North Am. Feburary 2008;26(1):217-231. [Medline].
Taiwo SS, Adesiji YO, Adekanle DA. Screening for syphilis during pregnancy in Nigeria: a practice that must continue. Sex Transm Infect. Aug 2007;83(5):357-8. [Medline].
[Guideline] American Academy of Pediatrics, American College of Obstetricians. Guidelines for Perinatal Care. 5th ed. 2002.
[Guideline] Screening for syphilis infection in pregnancy: U.S. Preventive Services Task Force reaffirmation recommendation statement. Ann Intern Med. May 19 2009;150(10):705-9. [Medline].
American Academy of Pediatrics. Syphillis. In: Red Book: Report of the Committee on Infectious Diseases. 26th ed. 2003:595-607.
American Academy of Pediatrics. Syphillis. In: Red Book: Report of the Committee on Infectious Diseases. 29th ed. 2009:639.
Knight CS, Crum MA, Hardy RW. Evaluation of the LIAISON Treponema Assay, a Chemiluminescent Immunoassay for the Diagnosis of Syphilis. Clin Vaccine Immunol. Apr 25 2007;[Medline].
Woznicova V, Valisova Z. Performance of CAPTIA SelectSyph-G enzyme-linked immunosorbent assay in syphilis testing of a high-risk population: analysis of discordant results. J Clin Microbiol. Jun 2007;45(6):1794-7. [Medline].
Kandelaki G, Kapila R, Fernandes H. Destructive osteomyelitis associated with early secondary syphilis in an HIV-positive patient diagnosed by Treponema pallidum DNA polymerase chain reaction. AIDS Patient Care STDS. Apr 2007;21(4):229-33. [Medline].
Wong T, Singh AE, De P. Primary syphilis: serological treatment response to doxycycline/tetracycline versus benzathine penicillin. Am J Med. October 2008;121(10):903-908. [Medline].
Bai ZG, Yang KH, Liu YL, et al. Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials. Int J STD AIDS. April 2008;19(4):217-221. [Medline].
Chau J, Atashband S, Chang E, Westerberg BD, Kozak FK. A systematic review of pediatric sensorineural hearing loss in congenital syphilis. Int J Pediatr Otorhinolaryngol. March 2009;[Medline].

