Pediatric Chickenpox Differential Diagnoses
- Author: Kirsten A Bechtel, MD; Chief Editor: Russell W Steele, MD more...
Diagnostic Considerations
Conditions that should be considered in the diagnosis of pediatric varicella include the following:
- Drug reactions
- Insect bites
- Measles
- Meningococcemia (can be confused with hemorrhagic varicella)
- Other common viral exanthems (eg, coxsackievirus, echovirus)
- Smallpox (no cases since 1949; virus officially destroyed in 1996)
- Papular urticaria
- Dermatitis herpetiformis
- Eczema herpeticum
Differential Diagnoses
- Contact Dermatitis
- Encephalitis
- Enteroviral Infections
- Henoch-Schonlein Purpura
- Herpes Simplex
- Herpes Simplex Virus Infection
- Herpes Zoster
- Impetigo
- Impetigo
- Pediatrics, Hand-Foot-and-Mouth Disease
- Scabies
- Stevens-Johnson Syndrome
- Toxic Shock Syndrome
- Urticaria
Hall S, Maupin T, Seward J, Jumaan AO, Peterson C, Goldman G, et al. Second varicella infections: are they more common than previously thought?. Pediatrics. Jun 2002;109(6):1068-73. [Medline].
Rockley PF, Tyring SK. Pathophysiology and clinical manifestations of varicella zoster virus infections. Int J Dermatol. Apr 1994;33(4):227-32. [Medline].
Dowell SF, Bresee JS. Severe varicella associated with steroid use. Pediatrics. Aug 1993;92(2):223-8. [Medline].
Davis MM, Patel MS, Gebremariam A. Decline in varicella-related hospitalizations and expenditures for children and adults after introduction of varicella vaccine in the United States. Pediatrics. Sep 2004;114(3):786-92. [Medline].
[Guideline] American Academy of Pediatrics Committee on Infectious Diseases. Prevention of varicella: recommendations for use of varicella vaccines in children, including a recommendation for a routine 2-dose varicella immunization schedule. Pediatrics. 2007;120:221-231. [Medline]. [Full Text].
Zhou F, Harpaz R, Jumaan AO, et al. Impact of varicella vaccination on health care utilization. JAMA. Aug 17 2005;294(7):797-802. [Medline]. [Full Text].
Nguyen HQ, Jumaan AO, Seward JF. Decline in mortality due to varicella after implementation of varicella vaccination in the United States. N Engl J Med. Feb 3 2005;352(5):450-8. [Medline].
Seward JF, Watson BM, Peterson CL, Mascola L, Pelosi JW, Zhang JX, et al. Varicella disease after introduction of varicella vaccine in the United States, 1995-2000. JAMA. Feb 6 2002;287(5):606-11. [Medline].
Shah SS, Wood SM, Luan X, Ratner AJ. Decline in varicella-related ambulatory visits and hospitalizations in the United States since routine immunization against varicella. Pediatr Infect Dis J. Mar 2010;29(3):199-204. [Medline]. [Full Text].
National, state, and local area vaccination coverage among children aged 19-35 months--United States, 2006. MMWR Morb Mortal Wkly Rep. Aug 31 2007;56(34):880-5. [Medline].
Buchholz U, Moolenaar R, Peterson C, Mascola L. Varicella outbreaks after vaccine licensure: should they make you chicken?. Pediatrics. Sep 1999;104(3 Pt 1):561-3. [Medline]. [Full Text].
Galil K, Lee B, Strine T, et al. Outbreak of varicella at a day-care center despite vaccination. N Engl J Med. Dec 12 2002;347(24):1909-15. [Medline]. [Full Text].
Seward JF, Zhang JX, Maupin TJ, Mascola L, Jumaan AO. Contagiousness of varicella in vaccinated cases: a household contact study. JAMA. Aug 11 2004;292(6):704-8. [Medline].
Ozaki T, Nagai H, Kimura T, Ichikawa T, Suzuki S, Kito H, et al. The age distribution of neutralizing antibodies against varicella-zoster virus in healthy individuals. Biken J. Mar 1980;23(1):9-14. [Medline].
Kouwabunpat D, Hoffman J, Adler R. Varicella complicated by group A streptococcal sepsis and osteonecrosis. Pediatrics. Oct 1999;104(4 Pt 1):967-9. [Medline]. [Full Text].
Perella D, Fiks AG, Jumaan A, Robinson D, Gargiullo P, Pletcher J, et al. Validity of reported varicella history as a marker for varicella zoster virus immunity among unvaccinated children, adolescents, and young adults in the post-vaccine licensure era. Pediatrics. May 2009;123(5):e820-8. [Medline].
Cowan MR, Primm PA, Scott SM, Abramo TJ, Wiebe RA. Serious group A beta-hemolytic streptococcal infections complicating varicella. Ann Emerg Med. Apr 1994;23(4):818-22. [Medline].
Doctor A, Harper MB, Fleisher GR. Group A beta-hemolytic streptococcal bacteremia: historical overview, changing incidence, and recent association with varicella. Pediatrics. Sep 1995;96(3 Pt 1):428-33. [Medline].
Lesko SM, O'Brien KL, Schwartz B, Vezina R, Mitchell AA. Invasive group A streptococcal infection and nonsteroidal antiinflammatory drug use among children with primary varicella. Pediatrics. May 2001;107(5):1108-15. [Medline].
Tappeiner C, Aebi C, Garweg JG. Retinitis and optic neuritis in a child with chickenpox: case report and review of literature. Pediatr Infect Dis J. Dec 2010;29(12):1150-2. [Medline].
Matsukura H, Murakami M, Sakaki H, Mitani T, Shimura S. Varicella glomerulonephritis preceding the cutaneous lesions. Clin Nephrol. Aug 2009;72(2):161-2. [Medline].
Pastuszak AL, Levy M, Schick B, et al. Outcome after maternal varicella infection in the first 20 weeks of pregnancy. N Engl J Med. Mar 31 1994;330(13):901-5. [Medline]. [Full Text].
Derrick CW Jr, Lord L. In utero varicella-zoster infections. South Med J. Nov 1998;91(11):1064-6. [Medline].
American Academy of Pediatrics Committee on Infectious Diseases: The use of oral acyclovir in otherwise healthy children with varicella. Pediatrics. Mar 1993;91(3):674-6. [Medline].
[Guideline] Marin M, Meissner HC, Seward JF. Varicella prevention in the United States: a review of successes and challenges. Pediatrics. Sep 2008;122(3):e744-51. [Medline]. [Full Text].
Pinquier D, Gagneur A, Balu L, et al. Prevalence of anti-varicella-zoster virus antibodies in French infants under 15 months of age. Clin Vaccine Immunol. Apr 2009;16(4):484-7. [Medline].
[Guideline] Update: recommendations from the Advisory Committee on Immunization Practices (ACIP) regarding administration of combination MMRV vaccine. MMWR Morb Mortal Wkly Rep. Mar 14 2008;57(10):258-60. [Medline].
[Guideline] Marin M, Güris D, Chaves SS, Schmid S, Seward JF. Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. Jun 22 2007;56:1-40. [Medline].
Lee LE, Ho H, Lorber E, et al. Vaccine-era varicella epidemiology and vaccine effectiveness in a public elementary school population, 2002-2007. Pediatrics. Jun 2008;121(6):e1548-54. [Medline]. [Full Text].
Verstraeten T, Jumaan AO, Mullooly JP, et al. A retrospective cohort study of the association of varicella vaccine failure with asthma, steroid use, age at vaccination, and measles-mumps-rubella vaccination. Pediatrics. Aug 2003;112(2):e98-103. [Medline]. [Full Text].
Chaves SS, Gargiullo P, Zhang JX, et al. Loss of vaccine-induced immunity to varicella over time. N Engl J Med. Mar 15 2007;356(11):1121-9. [Medline].
Arbeter AM, Granowetter L, Starr SE, et al. Immunization of children with acute lymphoblastic leukemia with live attenuated varicella vaccine without complete suspension of chemotherapy. Pediatrics. Mar 1990;85(3):338-44. [Medline].
Quian R J, Protasio P A, Dall'orso V P, et al. [Varicella outbreak in a village in Uruguay]. Rev Chilena Infectol. Feb 2010;27(1):47-51. [Medline]. [Full Text].
Watson B, Seward J, Yang A, Witte P, Lutz J, Chan C. Postexposure effectiveness of varicella vaccine. Pediatrics. Jan 2000;105(1 Pt 1):84-8. [Medline].
Klein NP, Fireman B, Yih WK, et al. Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. Pediatrics. Jul 2010;126(1):e1-8. [Medline].
Hviid A. Measles-mumps-rubella-varicella combination vaccine increases risk of febrile seizure. J Pediatr. Jan 2011;158(1):170. [Medline].
[Guideline] Marin M, Broder KR, Temte JL, Snider DE, Seward JF. Use of combination measles, mumps, rubella, and varicella vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. May 7 2010;59:1-12. [Medline].
American Academy of Pediatrics Committee on Infectious Diseases. Policy Statement--Prevention of Varicella: Update of Recommendations for Use of Quadrivalent and Monovalent Varicella Vaccines in Children. Pediatrics. Aug 28 2011;[Medline].

