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Pediatric Viral Hemorrhagic Fevers Treatment & Management

  • Author: Martha L Muller, MD; Chief Editor: Russell W Steele, MD  more...
Updated: Apr 10, 2013

Medical Care

Early diagnosis and supportive care can be lifesaving for most patients with viral hemorrhagic fever (VHF). The cornerstone of therapy for all these infections is judicious fluid and electrolyte management.

Blood, platelet, and plasma replacement may be useful for Crimean-Congo hemorrhagic fever (CCHF). High-dose corticosteroids, immune globulin intravenous, and fresh frozen plasma have also been reported to be successful in CCHF.[38] Infusion of convalescent plasma during the first 8 days of illness with Argentine HF reduces the mortality rate from 15-30% to less that 1%.

Novel treatment studies using positively-charged phosphorodiamidate morpholino oligomers (PMOplus) demonstrate protection of monkeys infected with Ebola and Marburg viruses.[39] These studies suggest a potential therapeutic modality for human infection for the future.

Studies of high-dose mannose-binding lectin therapy in mice suggest a promising future therapeutic modality for Ebola (and other viruses) infection.[40, 41]



See the list below:

  • Infectious diseases specialist (urgent)
  • Hematologist
  • Others as dictated by the clinical circumstances
Contributor Information and Disclosures

Martha L Muller, MD Associate Professor of Pediatrics, Division of Infectious Diseases, University of New Mexico School of Medicine

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Chief Editor

Russell W Steele, MD Clinical Professor, Tulane University School of Medicine; Staff Physician, Ochsner Clinic Foundation

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, Southern Medical Association

Disclosure: Nothing to disclose.

Additional Contributors

Glenn Fennelly, MD, MPH Director, Division of Infectious Diseases, Lewis M Fraad Department of Pediatrics, Jacobi Medical Center; Clinical Associate Professor of Pediatrics, Albert Einstein College of Medicine

Glenn Fennelly, MD, MPH is a member of the following medical societies: Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.


Leslie L Barton, MD Professor Emerita of Pediatrics, University of Arizona College of Medicine

Leslie L Barton, MD is a member of the following medical societies: American Academy of Pediatrics, Association of Pediatric Program Directors, Infectious Diseases Society of America, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Michelle L Whitner, PA-C Physician Assistant, pediatrics, Parker Pediatrics and Adolescents

Michelle L Whitner, PA-C is a member of the following medical societies: American Academy of Physician Assistants

Disclosure: Nothing to disclose.

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Ebola virus. Electron micrograph courtesy of the Centers for Disease Control and Prevention.
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