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Fetal Alcohol Syndrome Medication

  • Author: Keith K Vaux, MD; Chief Editor: Ted Rosenkrantz, MD  more...
 
Updated: Jan 16, 2015
 
 

Medication Summary

Some children with fetal alcohol syndrome or fetal alcohol syndrome disorder present with clinically significant impulsivity, hyperactivity, oppositional behavior, and/or sleep disorders. Medication may assist with these symptoms. However, whether these abnormalities due to prenatal alcohol exposure respond to medications that successfully treat these behaviors when they are due to other or unknown causes is not established. Therefore, the successful use of medication may depend on the individual child's history and presentation.

 
 
Contributor Information and Disclosures
Author

Keith K Vaux, MD Professor of Medicine, Clinical Chief and Division Director, Division of Medical Genetics, Department of Medicine, University of California, San Diego, School of Medicine; Director, Rare Disease Program, Rady Children's Hospital San Diego and UC San Diego

Keith K Vaux, MD is a member of the following medical societies: American Academy of Pediatrics, Western Society for Pediatric Research

Disclosure: Nothing to disclose.

Coauthor(s)

Christina Chambers, MPH, PhD Associate Professor of Pediatrics and Family and Preventive Medicine, University of California at San Diego; Assistant Professor, Graduate School of Public Health, San Diego State University

Christina Chambers, MPH, PhD is a member of the following medical societies: Society for Epidemiologic Research, Teratology Society, Research Society on Alcoholism, International Society for Pharmacoepidemiology

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Arun K Pramanik, MD, MBBS Professor of Pediatrics, Louisiana State University Health Sciences Center

Arun K Pramanik, MD, MBBS is a member of the following medical societies: American Academy of Pediatrics, American Thoracic Society, National Perinatal Association, Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Ted Rosenkrantz, MD Professor, Departments of Pediatrics and Obstetrics/Gynecology, Division of Neonatal-Perinatal Medicine, University of Connecticut School of Medicine

Ted Rosenkrantz, MD is a member of the following medical societies: American Academy of Pediatrics, American Pediatric Society, Eastern Society for Pediatric Research, American Medical Association, Connecticut State Medical Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

Additional Contributors

Oussama Itani, MD, FAAP, FACN Clinical Associate Professor of Pediatrics and Human Development, Michigan State University; Medical Director, Department of Neonatology, Borgess Medical Center

Oussama Itani, MD, FAAP, FACN is a member of the following medical societies: American Academy of Pediatrics, American Association for Physician Leadership, American Heart Association, American College of Nutrition

Disclosure: Nothing to disclose.

Acknowledgements

The authors gratefully acknowledge the contributions of Christine D Dittmer, MD, and Sarah L Lentz-Kapua, MD, to the writing and development of this article.

References
  1. Jones KL, Smith DW. Recognition of the fetal alcohol syndrome in early infancy. Lancet. 1973 Nov 3. 2(7836):999-1001. [Medline].

  2. Gray R, Mukherjee RA, Rutter M. Alcohol consumption during pregnancy and its effects on neurodevelopment: what is known and what remains uncertain. Addiction. 2009 Aug. 104(8):1270-3. [Medline].

  3. Keiver K, Bertram CP, Orr AP, Clarren S. Salivary cortisol levels are elevated in the afternoon and at bedtime in children with prenatal alcohol exposure. Alcohol. 2014 Dec 13. [Medline].

  4. Mattson SN, Roesch SC, Glass L, Deweese BN, Coles CD, Kable JA, et al. Further Development of a Neurobehavioral Profile of Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res. 2012 Sep 13. [Medline].

  5. Sujay NK, Jones M, Whittle E, Murphy H, Auth MK. Severe gastrooesophageal reflux disease associated with foetal alcohol syndrome. Case Rep Pediatr. 2012. 2012:509253. [Medline]. [Full Text].

  6. Colin Carter R, Jacobson JL, Molteno CD, Jiang H, Meintjes EM, Jacobson SW, et al. Effects of Heavy Prenatal Alcohol Exposure and Iron Deficiency Anemia on Child Growth and Body Composition through Age 9 Years. Alcohol Clin Exp Res. 2012 Aug 15. [Medline].

  7. Kuehn D, Aros S, Cassorla F, Avaria M, Unanue N, Henriquez C, et al. A prospective cohort study of the prevalence of growth, facial, and central nervous system abnormalities in children with heavy prenatal alcohol exposure. Alcohol Clin Exp Res. 2012 Oct. 36(10):1811-9. [Medline].

  8. Bonthius DJ, Tzouras G, Karacay B, Mahoney J, Hutton A, McKim R. Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing mice. Brain Res Dev Brain Res. 2002 Sep 20. 138(1):45-59. [Medline].

  9. Astley SJ, Aylward EH, Olson HC, et al. Magnetic Resonance Imaging Outcomes From a Comprehensive Magnetic Resonance Study of Children With Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res. 2009 Jul 1. [Medline].

  10. Karunamuni G, Gu S, Doughman YQ, et al. Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure. Dev Dyn. 2014 Dec 27. [Medline].

  11. Taylor PA, Jacobson SW, van der Kouwe A, et al. A DTI-based tractography study of effects on brain structure associated with prenatal alcohol exposure in newborns. Hum Brain Mapp. 2015 Jan. 36(1):170-86. [Medline].

  12. Rangmar J, Hjern A, Vinnerljung B, Strömland K, Aronson M, Fahlke C. Psychosocial outcomes of fetal alcohol syndrome in adulthood. Pediatrics. 2015 Jan. 135(1):e52-8. [Medline].

  13. Abel EL. "Moderate" drinking during pregnancy: cause for concern?. Clin Chim Acta. 1996 Mar 15. 246(1-2):149-54. [Medline].

  14. Abel EL. An update on incidence of FAS: FAS is not an equal opportunity birth defect. Neurotoxicol Teratol. 1995 Jul-Aug. 17(4):437-43. [Medline].

  15. Abel EL. Fetal alcohol syndrome: the American Paradox. Alcohol Alcohol. 1998 May-Jun. 33(3):195-201. [Medline].

  16. [Guideline] Bertrand J, Floyd LL, Weber MK. Guidelines for identifying and referring persons with fetal alcohol syndrome. MMWR Recomm Rep. 2005 Oct 28. 54:1-14. [Medline].

  17. Carmichael Olson H, Burgess DM, Streissguth AP. Fetal alcohol syndrome (FAS) and fetal alcohol effects (FAE): A lifespan view, with implications for intervention. Zero to Three/National Center for Clinical Infant Programs. 13(1):1992: 24-9.

  18. Clark CM, Li D, Conry J, et al. Structural and functional brain integrity of fetal alcohol syndrome in nonretarded cases. Pediatrics. 2000 May. 105(5):1096-9. [Medline].

  19. Day NL, Richardson GA. Prenatal alcohol exposure: a continuum of effects. Semin Perinatol. 1991 Aug. 15(4):271-9. [Medline].

  20. Flandermeyer A. The drug exposed neonate. Kenner C, ed. Comprehensive Neonatal Nursing: A Physiological Perspective. Philadelphia, PA: WB Saunders; 1993. 997-1033.

  21. Forrest F, Florey CD, Taylor D, McPherson F, Young JA. Reported social alcohol consumption during pregnancy and infants' development at 18 months. BMJ. 1991 Jul 6. 303(6793):22-6. [Medline].

  22. Hoyme HE, May PA, Kalberg WO, et al. A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria. Pediatrics. 2005 Jan. 115(1):39-47. [Medline].

  23. Iyasu S, Randall LL, Welty TK, et al. Risk factors for sudden infant death syndrome among northern plains Indians. JAMA. 2002 Dec 4. 288(21):2717-23. [Medline].

  24. Jacobson SW, Chiodo LM, Sokol RJ, Jacobson JL. Validity of maternal report of prenatal alcohol, cocaine, and smoking in relation to neurobehavioral outcome. Pediatrics. 2002 May. 109(5):815-25. [Medline].

  25. Kavale KA, Karge BD. Fetal alcohol syndrome: A behavioral teratology. The Exceptional Child. Columbus, OH: Charles E. Merrill; 1986. 1986: 4-16.

  26. Levy M, Koren G. Clinical toxicology of the neonate. Semin Perinatol. 1992 Feb. 16(1):63-75. [Medline].

  27. May PA, Brooke L, Gossage JP, et al. Epidemiology of fetal alcohol syndrome in a South African community in the Western Cape Province. Am J Public Health. 2000 Dec. 90(12):1905-12. [Medline].

  28. May PA, Gossage JP, White-Country M, et al. Alcohol consumption and other maternal risk factors for fetal alcohol syndrome among three distinct samples of women before, during, and after pregnancy: the risk is relative. Am J Med Genet C Semin Med Genet. 2004 May 15. 127(1):10-20. [Medline].

  29. Phelps L, Grabowski J. Fetal alcohol syndrome: Diagnostic features and psychoeducational risk factors. School Psychol Q. 1992. 7(2):112-28.

  30. Russell M. Clinical implications of recent research on the fetal alcohol syndrome. Bull N Y Acad Med. 1991 May-Jun. 67(3):207-22. [Medline].

  31. Russell M, Czarnecki DM, Cowan R, et al. Measures of maternal alcohol use as predictors of development in early childhood. Alcohol Clin Exp Res. 1991 Dec. 15(6):991-1000. [Medline].

  32. Sampson PD, Streissguth AP, Bookstein FL. Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. Teratology. 1997 Nov. 56(5):317-26. [Medline].

  33. Shaywitz SE, Cohen DJ, Shaywitz BA. Behavior and learning difficulties in children of normal intelligence born to alcoholic mothers. J Pediatr. 1980 Jun. 96(6):978-82. [Medline].

  34. Sommers M. Alcohol intoxication and multiple trauma: A catastrophic combination. Med Surg Nurs Q. 1992. 1:110-21.

  35. Spadoni AD, McGee CL, Fryer SL, Riley EP. Neuroimaging and fetal alcohol spectrum disorders. Neurosci Biobehav Rev. 2007. 31(2):239-45. [Medline].

  36. Stratton K, Howe C, Battaglia F. Fetal Alcohol Syndrome: Diagnosis, Epidemiology, Prevention, and Treatment. National Academy Press; 1996.

  37. Streissguth A, LaDue R. Psychological and behavioral effects in children prenatally exposed to alcohol. Alcohol Health Res World. 1985. 10:6-12.

  38. Streissguth AP, Barr HM, Sampson PD, Bookstein FL. Prenatal alcohol and offspring development: the first fourteen years. Drug Alcohol Depend. 1994 Oct. 36(2):89-99. [Medline].

  39. Taybi H. Handbook of Syndromes and Metabolic Disorders: Radiologic and Clinical Manifestations. Philadelphia, PA: Mosby-Year Book; 1998. 71-2.

  40. Warren KR, Li TK. Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disorders. Birth Defects Res A Clin Mol Teratol. 2005 Apr. 73(4):195-203. [Medline].

  41. West JR, Goodlett CR, Brandt JP. New approaches to research on the long-term consequences of prenatal exposure to alcohol. Alcohol Clin Exp Res. 1990 Oct. 14(5):684-9. [Medline].

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Facial characteristics of a child with fetal alcohol syndrome.
 
 
 
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