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Kernicterus

  • Author: Shelley C Springer, JD, MD, MSc, MBA, FAAP; Chief Editor: Ted Rosenkrantz, MD  more...
 
Updated: Apr 02, 2014
 

Background

The term kernicterus literally means "yellow kern," with kern indicating the most commonly afflicted region of the brain (ie, the nuclear region). Historically, the term refers to an anatomic diagnosis made at autopsy based on a characteristic pattern of staining found in babies who had marked hyperbilirubinemia before they died.

Hervieux first described the condition in 1847, and Schmorl first used the term kernicterus as early as 1903. Regions most commonly affected include the basal ganglia; hippocampus; geniculate bodies; and cranial nerve nuclei, such as the oculomotor, vestibular, and cochlear. The cerebellum can also be affected. Bilirubin-induced neurologic dysfunction (BIND) refers to the clinical signs associated with bilirubin toxicity (ie, hypotonia followed by hypertonia and/or opisthotonus or retrocollis) and is typically divided into acute and chronic phases. The 2 terms are commonly used interchangeably, but this use is not technically accurate because one refers to clinical manifestations and the other to an anatomic diagnosis.

Conventional wisdom characterizes kernicterus as prevalent in the 1950s and 1960s, virtually eradicated in the 1970s and 1980s, only to reappear during the 1990s. It was speculated that early discharge of term infants (before their serum bilirubin concentration peaks) could be a factor in the reemergence of this devastating neurologic affliction, and medical research focused on developing surveillance and treatment paradigms to eliminate the condition. Whereas it is undeniable that kernicterus remains a cause of major neurologic morbidity in the infant population, population studies of children born in California between 1988 and 1997 suggest the prevalence of kernicterus has remained virtually unchanged since 1980.[1]

Much of the traditional teaching regarding hyperbilirubinemia is now being questioned as more is learned about bilirubin metabolism and neurologic injury. Kernicterus is now recognized in the premature infant and, very rarely, in the term infant in the absence of profound hyperbilirubinemia[2] ; however, other problems (eg, acidosis or infection) are present in term infants without profound hyperbilirubinemia. Conversely, physiologic jaundice (sometimes to levels previously thought to be universally dangerous) has been recognized to be within the reference range in the first week of life in healthy term babies, particularly those who are breastfed. Jaundice of this type usually spontaneously resolves without sequelae.

Despite the lack of a clear-cut cause-and-effect relationship between kernicterus and the degree of hyperbilirubinemia, laboratory investigations have demonstrated that bilirubin is neurotoxic at a cellular level. Other in vitro studies have shown bilirubin to have more antioxidant capability than vitamin E, which is commonly assumed to be the most potent antioxidant in the human system.[3] This possible role of bilirubin in early protection against oxidative injury, coupled with identification of multiple neonatal mechanisms to preserve and potentiate bilirubin production, has led to speculation about an as-yet-unrecognized beneficial role for bilirubin in the human neonate.

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Pathophysiology

Bilirubin staining can be noted on autopsy of fresh specimens in the regions of the basal ganglia, hippocampus, substantia nigra, and brainstem nuclei. Such staining can occur in the absence of severe hyperbilirubinemia; in this situation, factors influencing permeability of the blood-brain barrier (eg, acidosis, infection) and the amount of unbound (versus albumin-bound) bilirubin may play a role.

Characteristic patterns of neuronal necrosis leading to the clinical findings consistent with chronic bilirubin encephalopathy are also essential in the pathophysiology of this entity. Bilirubin staining of the brain without accompanying neuronal necrosis can be observed in babies who did not demonstrate clinical signs of bilirubin encephalopathy but who succumbed from other causes. This staining is thought to be a secondary phenomenon, dissimilar from the staining associated with kernicterus.

Improved brain imaging modalities, such as MRI and ultrasonography, may be emerging as instrumental tools to help clarify the complex picture of kernicterus in contrast with asymptomatic bilirubin staining of brain tissues. Bilirubin staining has been suggested to be visualized on MRI as an increased signal in the posteromedial aspect of the globus pallidus. Despite its theoretical value, however, efforts to use cranial imaging in the clinical setting have remained unsatisfying. A 2008 case series by Gkoltsiou et al reported the inexplicable conclusion that, while all children with severe cerebral palsy and a history of hyperbilirubinemia had abnormal central grey matter on later scans, the characteristic central grey matter MRI features of kernicterus were not seen in early scans.[4]

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Epidemiology

Frequency

United States

The exact incidence of kernicterus is unknown. A pilot kernicterus registry monitoring the cases of babies with kernicterus in the United States who have been voluntarily reported shows 125 babies with chronic kernicterus enrolled in the registry from 1984-2002.[5, 6] All but 4 babies reported in the registry had been discharged from the hospital fewer than 72 hours after birth (97%). Five babies were born at home (4%). No sequelae were identified in 9 of 115 infants, and 1 was lost to follow-up.

International

In Denmark, 8 cases of kernicterus were reported from 1994-2002, whereas no cases had been reported for the preceding 20 years.[7] Following this report, from 2002-2005, a more vigilant approach was taken to the management of newborn jaundice, and no more cases have been reported in Denmark.[8] These combined data result in an overall incidence of kernicterus in Denmark of 1.1 in 100,000 live births from 1994-2005.

In June 2003, The Quarterly Bulletin of the Royal College of Paediatrics and Child Health announced the commencement of a surveillance program of cases of severe neonatal hyperbilirubinemia following anecdotal reports throughout Britain and Ireland of increasing observation of kernicterus.[9] A 2004 UK surveillance study has reported kernicterus occurring at a rate of 1 in 100,000 live births.

A Canadian survey published in 2004 assessed the frequency of extreme hyperbilirubinemia (serum bilirubin >427 μmol/L or >25 mg/dL) as 1:2,840 live births, of which 13 (2 in 100,000) had abnormal neurological outcomes at the time of discharge.[10]

Using these data, the risk of developing kernicterus in infants manifesting extreme hyperbilirubinemia (>25 mg/dL) can be estimated across populations. In Canada, this risk calculates to 1 in 17.6 infants, whereas in Denmark, the population risk is estimated as 1 in 16.2.[11] When the threshold of extreme hyperbilirubinemia is increased to >30 mg/dL (>513 μmol/L), the risk of developing kernicterus increases to 1 in 5.5-7 live births, depending on the reports. It should be noted that kernicterus also occurs in infants in whom bilirubin levels remained < 25 mg/dL, and the population risk of this occurrence remains unknown.

Hispanic and Asian populations appear to have a greater propensity to develop hyperbilirubinemia, although the underlying explanation for this observation remains elusive. Genetic variants, such as Gilbert disease or G6PD deficiency that occur in sequestered populations, result in geographic and/or ethnic differences in the risk and frequency of kernicterus.

Race

Among infants reported in the US kernicterus registry, 58% were white.[6] Asian and Hispanic babies born either in their native countries or in the United States and Native American and Eskimo infants have higher production levels of bilirubin than white infants. Black infants have lower production levels (see image below). The reasons for these racial differences have not been fully elucidated.

Typical patterns of total serum bilirubin levels i Typical patterns of total serum bilirubin levels in neonates of different racial origins. Used with the permission of the Academy of Pediatrics.

Sex

Male infants have consistently higher levels of serum bilirubin than do female infants. Among infants reported in the US kernicterus registry, 67% of the patients were male.[6]

Age

Acute bilirubin toxicity appears to occur in the first few days of life of the term infant. Preterm infants may be at risk of toxicity for slightly longer than a few days. If injury has occurred, the first phase of acute bilirubin encephalopathy appears within the first week of life.

The pilot kernicterus registry data show that, of 122 infants (all >35 weeks' gestational age at birth), symptoms became apparent in 13 babies (10.6%) aged 3.5 days or younger and in 66 babies (54%) aged 4-7 days.[12] In 36 babies (29.5%), symptoms did not appear until after the first week of life. Most of these babies (76%) were term infants (at least 37 completed weeks' gestation), and no infant was younger than 35 weeks' estimated gestational age. (See the Gestational Age from Estimated Date of Delivery calculator.)

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Contributor Information and Disclosures
Author

Shelley C Springer, JD, MD, MSc, MBA, FAAP Professor, University of Medicine and Health Sciences, St Kitts, West Indies; Clinical Instructor, Department of Pediatrics, University of Vermont College of Medicine; Clinical Instructor, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health

Shelley C Springer, JD, MD, MSc, MBA, FAAP is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Coauthor(s)

David J Annibale, MD Professor of Pediatrics, Director of Neonatology, Director of Fellowship Training Program in Neonatal-Perinatal Medicine, Department of Pediatrics, Medical University of South Carolina

David J Annibale, MD is a member of the following medical societies: American Academy of Pediatrics, National Perinatal Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

David A Clark, MD Chairman, Professor, Department of Pediatrics, Albany Medical College

David A Clark, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Pediatric Society, Christian Medical and Dental Associations, Medical Society of the State of New York, New York Academy of Sciences, Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Ted Rosenkrantz, MD Professor, Departments of Pediatrics and Obstetrics/Gynecology, Division of Neonatal-Perinatal Medicine, University of Connecticut School of Medicine

Ted Rosenkrantz, MD is a member of the following medical societies: American Academy of Pediatrics, American Pediatric Society, Eastern Society for Pediatric Research, American Medical Association, Connecticut State Medical Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

Additional Contributors

Oussama Itani, MD, FAAP, FACN Clinical Associate Professor of Pediatrics and Human Development, Michigan State University; Medical Director, Department of Neonatology, Borgess Medical Center

Oussama Itani, MD, FAAP, FACN is a member of the following medical societies: American Academy of Pediatrics, American Association for Physician Leadership, American Heart Association, American College of Nutrition

Disclosure: Nothing to disclose.

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Typical patterns of total serum bilirubin levels in neonates of different racial origins. Used with the permission of the Academy of Pediatrics.
Overview of bilirubin metabolism.
Hour-specific nomogram for total serum bilirubin and attendant risk of subsequent severe disease in term and preterm infants. Used with the permission of the Academy of Pediatrics.
Magnetic resonance image of 21-month-old with kernicterus. Area of abnormality is the symmetric high-intensity signal in the area of the globus pallidus (arrows). Courtesy of M.J. Maisels.
Neuronal changes observed in kernicterus. Courtesy of J.J. Volpe.
 
 
 
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