Adipsia Medication

  • Author: Vikas R Dharnidharka, MD, MPH; Chief Editor: Craig B Langman, MD   more...
 
Updated: Mar 12, 2012
 

Vasopressin analogs

Class Summary

These agents are indicated when diabetes insipidus coexists. Desmopressin is a synthetic antidiuretic hormone with actions that mimic vasopressin. It is used to treat diabetes insipidus, which deprives the kidney of its capacity to produce concentrated urine. This results in large volumes of dilute urine (polyuria) and excessive thirst (polydipsia). Elevated sodium serum concentrations may occur, but hypernatremia is more likely to be severe when fluid is restricted.

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Desmopressin acetate (DDAVP)

 

Increases cellular permeability of collecting ducts, resulting in reabsorption of water by kidneys.

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Contributor Information and Disclosures
Author

Vikas R Dharnidharka, MD, MPH  Associate Professor and Chief, Division of Pediatric Nephrology, University of Florida Health Science Center-Shands Children's Hospital

Vikas R Dharnidharka, MD, MPH is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, American Society of Pediatric Nephrology, American Society of Transplantation, and International Pediatric Transplant Association

Disclosure: Bristol-Myers-Squibb Consulting fee Consulting; Genzyme Honoraria Speaking and teaching; American Society of Transplantation Honoraria Speaking and teaching; Chimerix Honoraria Other

Specialty Editor Board

Uri S Alon, MD  Director of Bone and Mineral Disorders Clinic and Renal Research Laboratory, Children's Mercy Hospital of Kansas City; Professor, Department of Pediatrics, Division of Pediatric Nephrology, University of Missouri-Kansas City School of Medicine

Uri S Alon, MD is a member of the following medical societies: American Federation for Medical Research

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Adrian Spitzer, MD  Clinical Professor Emeritus, Department of Pediatrics, Albert Einstein College of Medicine

Adrian Spitzer, MD is a member of the following medical societies: American Academy of Pediatrics, American Federation for Medical Research, American Pediatric Society, American Society of Nephrology, American Society of Pediatric Nephrology, International Society of Nephrology, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Howard Trachtman, MD  Program Director, Pediatrics Research, Schneider Children's Hospital, Department of Pediatrics, Division of Nephrology, Professor, Albert Einstein College of Medicine

Howard Trachtman, MD is a member of the following medical societies: American Society of Hypertension, American Society of Nephrology, American Society of Pediatric Nephrology, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Craig B Langman, MD  The Isaac A Abt, MD, Professor of Kidney Diseases, Northwestern University, The Feinberg School of Medicine; Division Head of Kidney Diseases, Children's Memorial Hospital

Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, and International Society of Nephrology

Disclosure: NIH Grant/research funds None; Raptor Pharmaceuticals, Inc Grant/research funds None; Alexion Pharmaceuticals, Inc. Grant/research funds None

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Anatomic relationships between pituitary and hypothalamic areas of interest with respect to regulation of antidiuretic hormone (ADH) secretion and thirst sensation. AN = Anterior (hypothalamic) nucleus; AP = Anterior pituitary; OC = optic chiasm; OVLT = Organum vasculosum of lamina terminalis; PA = Preoptic (hypothalamic) area; PP = Posterior pituitary; PVN = Paraventricular (hypothalamic) nucleus; SON = Supraoptic (hypothalamic) nucleus.
 
 
 
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