Oliguria Follow-up

  • Author: Prasad Devarajan, MD; Chief Editor: Craig B Langman, MD   more...
 
Updated: Nov 22, 2011
 

Transfer

If the patient with oliguria requires close monitoring of hemodynamic status or if indications for acute dialysis are present, transfer the patient to a center with ICU facilities.

Next

Complications

Infections develop in 30-70% of patients and affect the respiratory system, urinary tract, and indwelling catheters. Impaired defenses due to uremia and inappropriate use of antibiotics may contribute to the high rate of infectious complications.

Cardiovascular complications are a result of fluid and sodium retention. They include hypertension, congestive heart failure, and pulmonary edema.

Hyperkalemia results in ECG abnormalities and arrhythmias.

Other complications include the following:

  • GI - Anorexia, nausea, vomiting, ileus, and bleeding
  • Hematologic - Anemia and platelet dysfunction
  • Neurologic - Confusion, asterixis, somnolence, and seizures
  • Other electrolyte/acid-base disorders - Metabolic acidosis, hyponatremia, hypocalcemia, and hyperphosphatemia
Previous
Next

Prognosis

Despite significant advances in supportive care and renal replacement therapy, high mortality rates in the setting of multiorgan failure have not significantly improved in the past few decades.

Patients die with renal failure; however, they do not die not because of renal failure. The patient succumbs because of involvement of other systems during the period of renal insufficiency. Oliguric acute renal failure is an independent risk factor for mortality, as well as for nonrenal complications.

On the other hand, prognosis from prerenal causes or from acute tubular necrosis in the absence of significant comorbid conditions is usually quite good if appropriate therapy is instituted in a timely fashion.

Previous
Next

Patient Education

For excellent patient education resources, see eMedicine's Diabetes Center. Also, visit eMedicine's patient education articles Acute Kidney Failure and Chronic Kidney Failure.

Previous
 
Contributor Information and Disclosures
Author

Prasad Devarajan, MD  Louise M Williams Endowed Chair in Pediatrics, Professor of Pediatrics and Developmental Biology, Director of Nephrology and Hypertension, Director of Clinical Nephrology Laboratories, CEO of Dialysis Unit, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine

Prasad Devarajan, MD is a member of the following medical societies: American Heart Association, American Society of Nephrology, American Society of Pediatric Nephrology, National Kidney Foundation, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Specialty Editor Board

Laurence Finberg, MD  Clinical Professor, Department of Pediatrics, University of California, San Francisco, School of Medicine and Stanford University School of Medicine

Laurence Finberg, MD is a member of the following medical societies: American Medical Association

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Luther Travis, MD  Professor Emeritus, Departments of Pediatrics, Nephrology and Diabetes, University of Texas Medical Branch School of Medicine

Luther Travis, MD is a member of the following medical societies: Alpha Omega Alpha, American Federation for Medical Research, International Society of Nephrology, and Texas Pediatric Society

Disclosure: Nothing to disclose.

Howard Trachtman, MD  Program Director, Pediatrics Research, Schneider Children's Hospital, Department of Pediatrics, Division of Nephrology, Professor, Albert Einstein College of Medicine

Howard Trachtman, MD is a member of the following medical societies: American Society of Hypertension, American Society of Nephrology, American Society of Pediatric Nephrology, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Craig B Langman, MD  The Isaac A Abt, MD, Professor of Kidney Diseases, Northwestern University, The Feinberg School of Medicine; Division Head of Kidney Diseases, Children's Memorial Hospital

Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, and International Society of Nephrology

Disclosure: NIH Grant/research funds None; Raptor Pharmaceuticals, Inc Grant/research funds None; Alexion Pharmaceuticals, Inc. Grant/research funds None

References
  1. Cerda J. Oliguria: an earlier and accurate biomarker of acute kidney injury?. Kidney Int. Oct 2011;80(7):699-701. [Medline].

  2. Mehrazma M, Hooman N, Otukesh H. Prognostic value of renal pathological findings in children with atypical hemolytic uremic syndrome. Iran J Kidney Dis. Nov 2011;5(6):380-5. [Medline].

  3. Adragna M, Balestracci A, García Chervo L, Steinbrun S, Delgado N, Briones L. Acute dialysis-associated peritonitis in children with D+ hemolytic uremic syndrome. Pediatr Nephrol. Oct 29 2011;[Medline].

  4. Bunchman TE, McBryde KD, Mottes TE, et al. Pediatric acute renal failure: outcome by modality and disease. Pediatr Nephrol. Dec 2001;16(12):1067-71. [Medline].

  5. Hui-Stickle S, Brewer ED, Goldstein SL. Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001. Am J Kidney Dis. Jan 2005;45(1):96-101. [Medline].

  6. Parikh CR, Devarajan P. New biomarkers of acute kidney injury. Crit Care Med. Apr 2008;36(4 Suppl):S159-65. [Medline].

  7. Gambaro G, Bertaglia G, Puma G, D'Angelo A. Diuretics and dopamine for the prevention and treatment of acute renal failure: a critical reappraisal. J Nephrol. May-Jun 2002;15(3):213-9. [Medline].

  8. Cantarovich F, Rangoonwala B, Lorenz H, et al. High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trial. Am J Kidney Dis. Sep 2004;44(3):402-9. [Medline].

  9. Abuelo JG. Normotensive ischemic acute renal failure. N Engl J Med. Aug 23 2007;357(8):797-805. [Medline].

  10. American Society of Nephrology. American Society of Nephrology Renal Research Report. J Am Soc Nephrol. Jul 2005;16(7):1886-903. [Medline]. [Full Text].

  11. Andreoli SP. Acute renal failure. Curr Opin Pediatr. Apr 2002;14(2):183-8. [Medline].

  12. Bellomo R, Ronco C, Kellum JA, et al. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. Aug 2004;8(4):R204-12. [Medline]. [Full Text].

  13. Bonventre JV, Zuk A. Ischemic acute renal failure: an inflammatory disease?. Kidney Int. Aug 2004;66(2):480-5. [Medline].

  14. Chertow GM, Burdick E, Honour M, et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. Nov 2005;16(11):3365-70. [Medline].

  15. Devarajan P. Cellular and molecular derangements in acute tubular necrosis. Curr Opin Pediatr. Apr 2005;17(2):193-9. [Medline].

  16. Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. Jun 2006;17(6):1503-20. [Medline].

  17. Devarajan P, Goldstein SL. Acute renal failure. In: Kher KK, Schnaper HW, Makker SP. Clinical Pediatric Nephrology. Second Edition. Oxon, UK: Informa Healthcare; 2007:3770390.

  18. Friedewald JJ, Rabb H. Inflammatory cells in ischemic acute renal failure. Kidney Int. Aug 2004;66(2):486-91. [Medline].

  19. Goldstein SL. Pediatric acute kidney injury: it's time for real progress. Pediatr Nephrol. Jul 2006;21(7):891-5. [Medline].

  20. Goldstein SL. Pediatric acute renal failure: demographics and treatment. Contrib Nephrol. 2004;144:284-90. [Medline].

  21. Gouyon JB, Guignard JP. Management of acute renal failure in newborns. Pediatr Nephrol. Sep 2000;14(10-11):1037-44. [Medline].

  22. Klahr S, Miller SB. Acute oliguria. N Engl J Med. Mar 5 1998;338(10):671-5. [Medline].

  23. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet. Jan 29-Feb 4 2005;365(9457):417-30. [Medline].

  24. Lameire NH, De Vriese AS, Vanholder R. Prevention and nondialytic treatment of acute renal failure. Curr Opin Crit Care. Dec 2003;9(6):481-90. [Medline].

  25. Mehta RL, Chertow GM. Acute renal failure definitions and classification: time for change?. J Am Soc Nephrol. Aug 2003;14(8):2178-87. [Medline]. [Full Text].

  26. Mehta RL, Pascual MT, Soroko S, et al. Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int. Oct 2004;66(4):1613-21. [Medline].

  27. Molitoris BA, Sutton TA. Endothelial injury and dysfunction: role in the extension phase of acute renal failure. Kidney Int. Aug 2004;66(2):496-9. [Medline].

  28. Perico N, Cattaneo D, Sayegh MH, Remuzzi G. Delayed graft function in kidney transplantation. Lancet. Nov 13-19 2004;364(9447):1814-27. [Medline].

  29. Rabb H, Colvin RB. Case records of the Massachusetts General Hospital. Case 31-2007. A 41-year-old man with abdominal pain and elevated serum creatinine. N Engl J Med. Oct 11 2007;357(15):1531-41. [Medline].

  30. Racusen LC. The morphologic basis of acute renal failure. In: Molitoris BA, Finn WF, eds. Acute Renal Failure. Philadelphia, PA: WB Saunders; 2004:1-12.

  31. Safirstein RL. Acute renal failure: from renal physiology to the renal transcriptome. Kidney Int Suppl. Oct 2004;S62-6. [Medline].

  32. Schrier RW. Need to intervene in established acute renal failure. J Am Soc Nephrol. Oct 2004;15(10):2756-8. [Medline]. [Full Text].

  33. Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med. Jul 8 2004;351(2):159-69. [Medline].

  34. Schrier RW, Wang W, Poole B, Mitra A. Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J Clin Invest. Jul 2004;114(1):5-14. [Medline]. [Full Text].

  35. Siegel NJ, Van Why SK, Devarajan P. Pathogenesis of acute renal failure. In: Avner ED, Harmon WE, Niaudet P, eds. Pediatric Nephrology. Philadelphia, PA: Lippincott Williams & Wilkins; 2004:1223.

  36. Star RA. Treatment of acute renal failure. Kidney Int. Dec 1998;54(6):1817-31. [Medline].

  37. Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. Aug 17 2005;294(7):813-8. [Medline].

  38. Warnock DG. Towards a definition and classification of acute kidney injury. J Am Soc Nephrol. Nov 2005;16(11):3149-50. [Medline].

Previous
Next
 
Pathogenesis of prerenal failure.
Compensatory mechanisms for preventing a fall in glomerular filtration rate (GFR) in the presence of prerenal failure.
Mechanisms of intrinsic acute renal failure.
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.