Renal Cortical Necrosis Clinical Presentation

  • Author: Prasad Devarajan, MD; Chief Editor: Craig B Langman, MD   more...
 
Updated: May 26, 2011
 

History

The following may be noted in the history of patients with renal cortical necrosis:

  • Renal failure (oliguria, hematuria, flank pain)
  • Neonatal conditions (perinatal asphyxia, bleeding, cyanotic heart disease)
  • Childhood conditions (diarrhea, vomiting, blood in stools, HUS)
  • Severe trauma
  • Snakebite (eg, sea snake, cobra, green pit viper, Russell viper)
  • Pregnancy (bleeding, abortion, symptoms of eclampsia)
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Physical Examination

Kidney findings may include abdominal or bilateral costovertebral tenderness and/or palpable, tender kidneys.

Findings in patients with shock may include hypotension, tachycardia, and/or delayed capillary refill.

Findings in pregnancy may include lower abdominal tenderness, contracted uterus, and/or vaginal bleeding.

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Contributor Information and Disclosures
Author

Prasad Devarajan, MD  Louise M Williams Endowed Chair in Pediatrics, Professor of Pediatrics and Developmental Biology, Director of Nephrology and Hypertension, Director of Clinical Nephrology Laboratories, Chief Executive Officer of Dialysis Unit, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine

Prasad Devarajan, MD is a member of the following medical societies: American Heart Association, American Society of Nephrology, American Society of Pediatric Nephrology, National Kidney Foundation, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Specialty Editor Board

Laurence Finberg, MD  Clinical Professor, Department of Pediatrics, University of California, San Francisco, School of Medicine and Stanford University School of Medicine

Laurence Finberg, MD is a member of the following medical societies: American Medical Association

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Luther Travis, MD  Professor Emeritus, Departments of Pediatrics, Nephrology and Diabetes, University of Texas Medical Branch School of Medicine

Luther Travis, MD is a member of the following medical societies: Alpha Omega Alpha, American Federation for Medical Research, International Society of Nephrology, and Texas Pediatric Society

Disclosure: Nothing to disclose.

Chief Editor

Craig B Langman, MD  The Isaac A Abt, MD, Professor of Kidney Diseases, Northwestern University, The Feinberg School of Medicine; Division Head of Kidney Diseases, Children's Memorial Hospital

Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, and International Society of Nephrology

Disclosure: Merck Grant/research funds None; NIH Grant/research funds None; Raptor Pharmaceuticals, Inc Grant/research funds None; Alexion Pharmaceuticals, Inc. Grant/research funds None

References
  1. Kamioka I, Nozu K, Fujita T, Kaito H, Tanaka R, Yoshiya K, et al. Prognosis and pathological characteristics of five children with non-Shiga toxin-mediated hemolytic uremic syndrome. Pediatr Int. Apr 2007;49(2):196-201. [Medline].

  2. Prakash J, Vohra R, Wani IA, Murthy AS, Srivastva PK, Tripathi K, et al. Decreasing incidence of renal cortical necrosis in patients with acute renal failure in developing countries: a single-centre experience of 22 years from Eastern India. Nephrol Dial Transplant. Apr 2007;22(4):1213-7. [Medline].

  3. Ali A, Ali MA, Ali MU, Mohammad S. Hospital outcomes of obstetrical-related acute renal failure in a tertiary care teaching hospital. Ren Fail. 2011;33(3):285-90. [Medline].

  4. Papnicolaou N, Francis IR, Casalino DD, Arellano RS, Baumgarten DA, Curry NS, et al. ACR Appropriateness Criteria renal failure. [online publication]. Reston, VA: American College of Radiology (ACR); 2008.

  5. Archer L, Kilburn-Toppin F, Sneddon K, et al. A "fussy eater" with renal failure. Lancet. Feb 20 2010;375(9715):696. [Medline].

  6. Krishna GS, Kishore KC, Sriram NP, et al. Bilateral renal cortical necrosis in acute pancreatitis. Indian J Nephrol. Jul 2009;19(3):125. [Medline]. [Full Text].

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