eMedicine Specialties > Pediatrics: General Medicine > Nephrology

Renal Cortical Necrosis: Differential Diagnoses & Workup

Author: Elif Erkan, MD, Assistant Professor, Department of Pediatrics, Division of Pediatric Nephrology, University of Rochester School of Medicine
Coauthor(s): Prasad Devarajan, MD, Louise M Williams Endowed Chair in Pediatrics, Professor of Pediatrics and Developmental Biology, Director of Nephrology and Hypertension, Director of Clinical Nephrology Laboratories, Chief Executive Officer of Dialysis Unit, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
Contributor Information and Disclosures

Updated: Dec 13, 2007

Differential Diagnoses

Acute Tubular Necrosis

Other Problems to Be Considered

Renal artery thromboembolism
Renal infarction
Renal vein thrombosis

Workup

Laboratory Studies

  • Serum electrolyte measurements and renal function tests are used to check for hyperkalemia, hypocalcemia, metabolic acidosis, and elevated creatinine.
  • A CBC count may reveal hemolytic anemia and thrombocytopenia.
  • Coagulation studies detect low fibrinogen levels and increased fibrin-degradation products.
  • Urinalysis detects hematuria, proteinuria, RBC casts, and granular casts.

Imaging Studies

  • Radiography: Thin cortical shells or tram lines caused by calcification are a radiologic hallmark, but they develop only 4-5 weeks after the initial insult.
  • Ultrasonography
    • The sonogram initially shows enlarged kidneys with reduced blood flow.
    • Cortical tissue becomes shrunken later in disease progression.
  • Contrast-enhanced CT scanning
    • CT scanning with contrast are the most sensitive imaging modality.
    • Diagnostic features include absent opacification of the renal cortex and enhancement of subcapsular and juxtamedullary areas and of the medulla without excretion of contrast medium.
    • Initiating hemodialysis immediately after the procedure may be necessary to minimize further contrast-mediated renal damage.
  • Renal scanning
    • Diethylenetriamine pentaacetic acid (DTPA) scan reveals markedly diminished perfusion with delayed or no function.
    • Renal scan is the imaging technique of choice to diagnose renal cortical necrosis (RCN) in transplant kidneys or if contrast-enhanced CT scanning are unavailable.

Procedures

  • Kidney biopsy findings provide the definitive diagnosis and prognostic information; biopsy is indicated if the diagnosis is unclear and when no contraindications are present.

Histologic Findings

  • RCN is classified into 5 pathologic forms, depending on severity, as shown below. RCN classifications are as follows:
    • Focal pathologic form: Kidneys show focally necrotic glomeruli without thrombosis and patchy necrosis of tubules.
    • Minor pathologic form: Larger foci of necrosis are evident with vascular and glomerular thrombi.
    • Patchy pathologic form: Patches of necrosis may occupy two thirds of the cortex.
    • Gross pathologic form: Almost the entire cortex is involved. Thrombosis of the arteries is more widespread.
    • Confluent pathologic form: Kidneys show widespread glomerular and tubular necrosis with no arterial involvement.
  • Studies have shown that patients with HUS with thrombotic microangiopathy (TMA) involving arteries have a higher likelihood of progressing into acute cortical necrosis compared with patients with predominant glomerular TMA.2

More on Renal Cortical Necrosis

Overview: Renal Cortical Necrosis
Differential Diagnoses & Workup: Renal Cortical Necrosis
Treatment & Medication: Renal Cortical Necrosis
Follow-up: Renal Cortical Necrosis
References
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References

  1. Prakash J, Vohra R, Wani IA, et al. Decreasing incidence of renal cortical necrosis in patients with acute renal failure in developing countries: a single-centre experience of 22 years from Eastern India. Nephrol Dial Transplant. Apr 2007;22(4):1213-7. [Medline].

  2. Kamioka I, Nozu K, Fujita T, et al. Prognosis and pathological characteristics of five children with non-Shiga toxin-mediated hemolytic uremic syndrome. Pediatr Int. Apr 2007;49(2):196-201. [Medline].

  3. Ali BH, Al-Qarawi AA, Mahmoud OM, Hashad M. Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats. Basic Clin Pharmacol Toxicol. Jul 2004;95(1):20-3. [Medline].

  4. Ali SS, Rizvi SZ, Muzaffar S, et al. Renal cortical necrosis: a case series of nine patients & review of literature. J Ayub Med Coll Abbottabad. Apr-Jun 2003;15(2):41-4. [Medline].

  5. Chugh KS, Jha V, Sakhuja V, Joshi K. Acute renal cortical necrosis--a study of 113 patients. Ren Fail. 1994;16(1):37-47. [Medline].

  6. Hashimoto S, Shiroshita K, Sakurai T, et al. Unilateral renal cortical necrosis with contralateral hydronephrosis after surgery for uterus carcinoma. Clin Exp Nephrol. Mar 2003;7(1):72-6. [Medline].

  7. Lerner GR, Kurnetz R, Bernstein J, et al. Renal cortical and renal medullary necrosis in the first 3 months of life. Pediatr Nephrol. Nov 1992;6(6):516-8. [Medline].

  8. Mertens PR, Duque-Reina D, Ittel TH, et al. Contrast-enhanced computed tomography for demonstration of bilateral renal cortical necrosis. Clin Investig. Jul 1994;72(7):499-501. [Medline].

  9. Racusen LC, Solez K. Renal infarction, cortical necrosis, and atheroembolic disease. In: Tisher CC, Brenner BM, eds. Renal Pathology. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1994:810-31.

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Further Reading

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Keywords

renal cortical necrosis, RCN, acute renal failure, acute renal failure in pregnancy, kidney failure, dehydration, placental abruption, ischemic necrosis of the renal cortex, renal arterial perfusion, acute tubular necrosis, hemolytic uremic syndrome, HUS, septic abortion, acute renal failure, oliguria, hematuria, perinatal asphyxia, cyanotic heart disease, eclampsia, hypotension, congenital heart disease, anemia, hemolytic disease, gastroenteritis

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Contributor Information and Disclosures

Author

Elif Erkan, MD, Assistant Professor, Department of Pediatrics, Division of Pediatric Nephrology, University of Rochester School of Medicine
Disclosure: Nothing to disclose.

Coauthor(s)

Prasad Devarajan, MD, Louise M Williams Endowed Chair in Pediatrics, Professor of Pediatrics and Developmental Biology, Director of Nephrology and Hypertension, Director of Clinical Nephrology Laboratories, Chief Executive Officer of Dialysis Unit, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
Prasad Devarajan, MD is a member of the following medical societies: American Heart Association, American Society of Nephrology, American Society of Pediatric Nephrology, National Kidney Foundation, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Medical Editor

Laurence Finberg, MD, Clinical Professor, Department of Pediatrics, University of California at San Francisco and Stanford University
Laurence Finberg, MD is a member of the following medical societies: American Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine.com, Inc
Disclosure: Pfizer Inc Stock Investment from broker recommendation; Avanir Pharma Stock Investment from broker recommendation

Managing Editor

Luther Travis, MD, William W Glauser Professor of Pediatrics and Pediatric Nephrology, Department of Pediatrics, Divisions of Nephrology and Diabetes, University of Texas Medical Branch and Children's Hospital
Luther Travis, MD is a member of the following medical societies: Alpha Omega Alpha, American Federation for Medical Research, International Society of Nephrology, and Texas Pediatric Society
Disclosure: Nothing to disclose.

CME Editor

Howard Trachtman, MD, Program Director, Pediatrics Research, Schneider Children's Hospital, Department of Pediatrics, Division of Nephrology, Professor, Albert Einstein College of Medicine
Howard Trachtman, MD is a member of the following medical societies: American Society of Hypertension, American Society of Nephrology, American Society of Pediatric Nephrology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Chief Editor

Craig B Langman, MD, The Isaac A Abt, MD, Professor of Kidney Diseases, Feinberg School of Medicine, Northwestern University; Division Head of Kidney Diseases, Children's Memorial Hospital, Chicago
Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, and International Society of Nephrology
Disclosure: Amgen Grant/research funds None; Abbott Honoraria Speaking and teaching; Altus Pharmaceuticals Grant/research funds None; Genzyme Grant/research funds None; Merck Grant/research funds None

 
 
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