Renal Glucosuria Follow-up

  • Author: Rajendra Bhimma, MB, ChB, MD, DCH (SA), FCP (Paeds)(SA), MMed (Natal); Chief Editor: Craig B Langman, MD   more...
 
Updated: Aug 19, 2011
 

Further Outpatient Care

  • Routine medical follow-up care with the primary care provider is required for patients with renal glucosuria.
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Prognosis

  • Prognosis for benign renal glucosuria is excellent.
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Patient Education

  • Benign renal glucosuria has no relationship to diabetes mellitus. Ensure that the patient and family understand this and the excellent prognosis.
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Contributor Information and Disclosures
Author

Rajendra Bhimma, MB, ChB, MD, DCH (SA), FCP (Paeds)(SA), MMed (Natal)  Associate Professor of Pediatrics, Principal Specialist, Department of Pediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, South Africa

Rajendra Bhimma, MB, ChB, MD, DCH (SA), FCP (Paeds)(SA), MMed (Natal) is a member of the following medical societies: American Association for the Advancement of Science, International Pediatric Transplant Association, International Society of Nephrology, South African Medical Association, South African Paediatric Association, and South African Transplant Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Laurence Finberg, MD  Clinical Professor, Department of Pediatrics, University of California, San Francisco, School of Medicine and Stanford University School of Medicine

Laurence Finberg, MD is a member of the following medical societies: American Medical Association

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Luther Travis, MD  Professor Emeritus, Departments of Pediatrics, Nephrology and Diabetes, University of Texas Medical Branch School of Medicine

Luther Travis, MD is a member of the following medical societies: Alpha Omega Alpha, American Federation for Medical Research, International Society of Nephrology, and Texas Pediatric Society

Disclosure: Nothing to disclose.

Howard Trachtman, MD  Program Director, Pediatrics Research, Schneider Children's Hospital, Department of Pediatrics, Division of Nephrology, Professor, Albert Einstein College of Medicine

Howard Trachtman, MD is a member of the following medical societies: American Society of Hypertension, American Society of Nephrology, American Society of Pediatric Nephrology, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Craig B Langman, MD  The Isaac A Abt, MD, Professor of Kidney Diseases, Northwestern University, The Feinberg School of Medicine; Division Head of Kidney Diseases, Children's Memorial Hospital

Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, and International Society of Nephrology

Disclosure: Merck Grant/research funds None; NIH Grant/research funds None; Raptor Pharmaceuticals, Inc Grant/research funds None; Alexion Pharmaceuticals, Inc. Grant/research funds None

Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous author, Leonard G Feld, MD, PhD, to the development and writing of this article.

References
  1. Brown GK. Glucose transporters: structure, function and consequences of deficiency. J Inherit Metab Dis. May 2000;23(3):237-46. [Medline].

  2. Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med. Jan 2007;261(1):32-43. [Medline].

  3. Kloeckener-Gruissem B, Vandekerckhove K, Nürnberg G, Neidhardt J, Zeitz C, Nürnberg P. Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria. Am J Hum Genet. Mar 2008;82(3):772-9. [Medline].

  4. Wright EM, Turk E. The sodium/glucose cotransport family SLC5. Pflugers Arch. Feb 2004;447(5):510-8. [Medline].

  5. Ganapathy V, Thangaraju M, Gopal E, Martin PM, Itagaki S, Miyauchi S, et al. Sodium-coupled monocarboxylate transporters in normal tissue and in cancer. AAPS J. 2008;10:193-199.

  6. Hediger MA, Coady MJ, Ikeda TS, Wright EM. Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature. Nov 26-Dec 2 1987;330(6146):379-81. [Medline].

  7. Kanai Y, Lee WS, You G, Brown D, Hediger MA. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J Clin Invest. Jan 1994;93(1):397-404. [Medline].

  8. Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C. A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A. Sep 30 2003;100(20):11753-8. [Medline].

  9. Calado J, Soto K, Clemente C, Correia P, Rueff J. Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria. Hum Genet. Feb 2004;114(3):314-6. [Medline].

  10. Calado J, Loeffler J, Sakallioglu O, Gok F, Lhotta K, Barata J. Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting. Kidney Int. Mar 2006;69(5):852-5. [Medline].

  11. Calado J, Sznajer Y, Metzger D, Rita A, Hogan MC, Kattamis A. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrol Dial Transplant. Dec 2008;23(12):3874-9. [Medline].

  12. Quamme GA, Freeman HJ. Evidence for a high-affinity sodium-dependent D-glucose transport system in the kidney. Am J Physiol. Jul 1987;253(1 Pt 2):F151-7. [Medline].

  13. Santer R, Kinner M, Lassen CL, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol. Nov 2003;14(11):2873-82. [Medline]. [Full Text].

  14. Freitas HS, D'Agord Schaan B, da Silva RS, Okamoto MM, Oliveira-Souza M, Machado UF. Insulin but not phlorizin treatment induces a transient increase in GLUT2 gene expression in the kidney of diabetic rats. Nephron Physiol. 2007;105(3):p42-51. [Medline].

  15. Oemar BS, Byrd DJ, Brodehl J. Complete absence of tubular glucose reabsorption: a new type of renal glucosuria (type 0). Clin Nephrol. Mar 1987;27(3):156-60. [Medline].

  16. De Paoli P, Battistin S, Jus A, Reitano M, Villalta D, De Marchi S. Immunological characterization of renal glycosuria patients. Clin Exp Immunol. May 1984;56(2):289-94. [Medline].

  17. Gotzsche O. Renal glucosuria and aminoaciduria. Acta Med Scand. 1977;202(1-2):65-7. [Medline].

  18. Sankarasubbaiyan S, Cooper C, Heilig CW. Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine. Am J Kidney Dis. May 2001;37(5):1039-43. [Medline].

  19. Bingham C, Ellard S, Nicholls AJ, Pennock CA, Allen J, James AJ. The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria. Diabetes. Sep 2001;50(9):2047-52. [Medline].

  20. Santer R, Calado J. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol. Jan 2010;5(1):133-41. [Medline].

  21. Brodehl J, Franken A, Gellissen K. Maximal tubular reabsorption of glucose in infants and children. Acta Paediatr Scand. Jul 1972;61(4):413-20. [Medline].

  22. Calado J, Loeffler J, Sakallioglu O, Gok F, Lhotta K, Barata J. Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting. Kidney Int. Mar 2006;69(5):852-5. [Medline].

  23. Crombie DL. Incidence of glycosuria and diabetes. Proc R Soc Med. 1961;55:205.

  24. De Marchi S, Cecchin E, Basile A, Proto G, Donadon W, Schinella D. Is renal glycosuria a benign condition?. Proc Eur Dial Transplant Assoc. 1983;20:681-5. [Medline].

  25. Desjeuz JF, Turk E, Wright E. Congenital selective Na+ D-glucose co-transport defects leading to renal glycosuria and congenital selective intestinal malabsorption of glucose and galactose. In: The Metabolic and Molecular Basis of Inherited Diseases. 1995:3563-80.

  26. Elias LJ, Longo N. Glucose transporters. Ann Rev Med. 1992;43:377-393. [Medline].

  27. Elsas LJ, Rosenberg LE. Familial renal glycosuria: a genetic reappraisal of hexose transport by kidney and intestine. J Clin Invest. Oct 1969;48(10):1845-54. [Medline]. [Full Text].

  28. Francis J, Zhang J, Farhi A, Carey H, Geller DS. A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. Nephrol Dial Transplant. Nov 2004;19(11):2893-5. [Medline].

  29. Francis J, Zhang J, Farhi A, et al. A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. Nephrol Dial Transplant. Nov 2004;19(11):2893-5. [Medline].

  30. Freitas HS, Anhê GF, Melo KF, Okamoto MM, Oliveira-Souza M, Bordin S. Na(+) -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity. Endocrinology. Feb 2008;149(2):717-24. [Medline].

  31. Harkness J. Prevalence of glycosuria and diabetes mellitus. A comprehensive survey in an urban community. Br Med J. Jun 2 1962;5291:1503-7. [Medline].

  32. Jackson WP, Marine N, Vinik AI. The significance of glycosuria. Lancet. May 4 1968;1(7549):933-6. [Medline].

  33. Jones DP, Chesney RW. Development of tubular function. Clin Perinatol. Mar 1992;19(1):33-57. [Medline].

  34. Kamran M, Peterson RG, Dominguez JH. Overexpression of GLUT2 gene in renal proximal tubules of diabetic Zucker rats. J Am Soc Nephrol. Jun 1997;8(6):943-8. [Medline].

  35. Keller DM. Glucose excretion in man and dog. Nephron. 1968;5(1):43-66. [Medline].

  36. Kleta R, Stuart C, Gill FA, Gahl WA. Renal glucosuria due to SGLT2 mutations. Mol Genet Metab. May 2004;82(1):56-8. [Medline].

  37. Loo DD, Wright EM, Zeuthen T. Water pumps. J Physiol. Jul 1 2002;542(Pt 1):53-60. [Medline].

  38. Magen D, Sprecher E, Zelikovic I, Skorecki K. A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessiverenal glucosuria and aminoaciduria. Kidney Int. Jan 2005;67(1):34-41. [Medline].

  39. Marble A. Nondiabetic melituria. In: Marble A, White P, Bradley RF, et al eds. Joslin's Diabetes Mellitus. 11th ed. Philadelphia, Pa: BC Decker Inc; 1971.

  40. Oemar BS, Byrd DJ, Brodehl J. Complete absence of tubular glucose reabsorption: a new type of renal glucosuria (type 0). Clin Nephrol. Mar 1987;27(3):156-60. [Medline].

  41. Oemar BS, Byrd DJ, Brodehl J. Complete absence of tubular glucose reabsorption: a new type of renal glucosuria (type 0). Clin Nephrol. Mar 1987;27(3):156-60. [Medline].

  42. Pajor AM, Wright EM. Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family. J Biol Chem. Feb 25 1992;267(6):3557-60. [Medline].

  43. Renal glycosuria. In: Brodehl J, Edelmann CM Jr, eds. Pediatric Kidney Disease. 2nd ed. Little Brown & Co; 1992:1801-10.

  44. Pontoglio M, Prié D, Cheret C, Doyen A, Leroy C, Froguel P. HNF1alpha controls renal glucose reabsorption in mouse and man. EMBO Rep. Oct 2000;1(4):359-65. [Medline].

  45. Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol. Nov 2003;14(11):2873-82. [Medline].

  46. Simmons RA. Cell glucose transport and glucose handling during fetal and neonatal development. In: Rolin RA, Fox WW, eds. Fetal and Neonatal Physiology. 2nd ed. Philadelphia, PA: WB Saunders Co; 1998:585-90.

  47. Spitzer A. The developing kidney and the process of growth. In: The Seldin DW, Giebisch G, eds. Kidney: Physiology and Pathophysiology. 1985.

  48. Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol. Sep 1992;263(3 Pt 2):F459-65. [Medline].

  49. Woolf LI, Goodwin BL, Phelps CE. T-m-limited renal tubular reabsorption and the genetics of renal glucosuria. J Theor Biol. May 1966;11(1):10-21. [Medline].

  50. Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med. Jan 2007;261(1):32-43. [Medline].

  51. Wu CJ. Transient renal glycosuria in a patient with acute pyelonephritis. Intern Med. Jun 2001;40(6):519-21. [Medline].

  52. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3). Nature. Dec 5 1996;384(6608):455-8. [Medline].

  53. Zelikovic I. Aminoaciduria and glycosuria. In: Barratt TM, Avner ED, Harmon WE, eds. Pediatric Nephrology. 4th ed. Lippincott Williams & Wilkins; 1999:507-27.

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