eMedicine Specialties > Pediatrics: General Medicine > Nephrology

Renal Glucosuria: Treatment & Medication

Author: Rajendra Bhimma, MB, ChB, MD, DCH (SA), FCP (Paeds)(SA), MMed (Natal), Associate Professor of Pediatrics, Principal Specialist, Department of Pediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, South Africa
Contributor Information and Disclosures

Updated: Feb 17, 2009

Treatment

Medical Care

Benign renal glucosuria is a self-limiting process and requires no special medical care. If other associated findings suggest tubular disorders, then other interventions are required.

Consultations

Consultation with a pediatric nephrologist may be appropriate.

Diet

No special dietary instructions are required. In a very rare case of extremely large amounts of urinary glucose, glucose or another carbohydrate may be required during episodes of great physical activity to prevent hypoglycemia.

Medication

No treatment is required for benign renal glucosuria.

More on Renal Glucosuria

Overview: Renal Glucosuria
Differential Diagnoses & Workup: Renal Glucosuria
Treatment & Medication: Renal Glucosuria
Follow-up: Renal Glucosuria
References

References

  1. Calado J, Soto K, Clemente C, Correia P, Rueff J. Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria. Hum Genet. Feb 2004;114(3):314-6. [Medline].

  2. Calado J, Loeffler J, Sakallioglu O, Gok F, Lhotta K, Barata J. Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting. Kidney Int. Mar 2006;69(5):852-5. [Medline].

  3. Calado J, Sznajer Y, Metzger D, Rita A, Hogan MC, Kattamis A. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrol Dial Transplant. Dec 2008;23(12):3874-9. [Medline].

  4. Brodehl J, Franken A, Gellissen K. Maximal tubular reabsorption of glucose in infants and children. Acta Paediatr Scand. Jul 1972;61(4):413-20. [Medline].

  5. Crombie DL. Incidence of glycosuria and diabetes. Proc R Soc Med. 1961;55:205.

  6. Desjeuz JF, Turk E, Wright E. Congenital selective Na+ D-glucose co-transport defects leading to renal glycosuria and congenital selective intestinal malabsorption of glucose and galactose. In: The Metabolic and Molecular Basis of Inherited Diseases. 1995:3563-80.

  7. Elias LJ, Longo N. Glucose transporters. Ann Rev Med. 1992;43:377-393. [Medline].

  8. Elsas LJ, Rosenberg LE. Familial renal glycosuria: a genetic reappraisal of hexose transport by kidney and intestine. J Clin Invest. Oct 1969;48(10):1845-54. [Medline][Full Text].

  9. Francis J, Zhang J, Farhi A, Carey H, Geller DS. A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. Nephrol Dial Transplant. Nov 2004;19(11):2893-5. [Medline].

  10. Francis J, Zhang J, Farhi A, et al. A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. Nephrol Dial Transplant. Nov 2004;19(11):2893-5. [Medline].

  11. Harkness J. Prevalence of glycosuria and diabetes mellitus. A comprehensive survey in an urban community. Br Med J. Jun 2 1962;5291:1503-7. [Medline].

  12. Jackson WP, Marine N, Vinik AI. The significance of glycosuria. Lancet. May 4 1968;1(7549):933-6. [Medline].

  13. Jones DP, Chesney RW. Development of tubular function. Clin Perinatol. Mar 1992;19(1):33-57. [Medline].

  14. Keller DM. Glucose excretion in man and dog. Nephron. 1968;5(1):43-66. [Medline][Full Text].

  15. Kleta R, Stuart C, Gill FA, Gahl WA. Renal glucosuria due to SGLT2 mutations. Mol Genet Metab. May 2004;82(1):56-8. [Medline].

  16. Magen D, Sprecher E, Zelikovic I, Skorecki K. A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessiverenal glucosuria and aminoaciduria. Kidney Int. Jan 2005;67(1):34-41. [Medline].

  17. Marble A. Nondiabetic melituria. In: Marble A, White P, Bradley RF, et al eds. Joslin's Diabetes Mellitus. 11th ed. Philadelphia, Pa: BC Decker Inc; 1971.

  18. Pajor AM, Wright EM. Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family. J Biol Chem. Feb 25 1992;267(6):3557-60. [Medline].

  19. Renal glycosuria. In: Brodehl J, Edelmann CM Jr, eds. Pediatric Kidney Disease. 2nd ed. Little Brown & Co; 1992:1801-10.

  20. Santer R, Kinner M, Lassen CL, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol. Nov 2003;14(11):2873-82. [Medline][Full Text].

  21. Simmons RA. Cell glucose transport and glucose handling during fetal and neonatal development. In: Rolin RA, Fox WW, eds. Fetal and Neonatal Physiology. 2nd ed. Philadelphia, PA: WB Saunders Co; 1998:585-90.

  22. Spitzer A. The developing kidney and the process of growth. In: The Seldin DW, Giebisch G, eds. Kidney: Physiology and Pathophysiology. 1985.

  23. Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol. Sep 1992;263(3 Pt 2):F459-65. [Medline].

  24. Woolf LI, Goodwin BL, Phelps CE. T-m-limited renal tubular reabsorption and the genetics of renal glucosuria. J Theor Biol. May 1966;11(1):10-21. [Medline].

  25. Wu CJ. Transient renal glycosuria in a patient with acute pyelonephritis. Intern Med. Jun 2001;40(6):519-21. [Medline].

  26. Zelikovic I. Aminoaciduria and glycosuria. In: Barratt TM, Avner ED, Harmon WE, eds. Pediatric Nephrology. 4th ed. Lippincott Williams & Wilkins; 1999:507-27.

Further Reading

Keywords

renal glucosuria, renal glycosuria, glucose in urine, familial renal glycosuria, FRG, Fanconi syndrome, cystinosis, Wilson disease, hereditary tyrosinemia, oculocerebrorenal syndrome, Lowe syndrome, hyperglycemia, diabetes mellitus, hypophosphatemic rickets, dehydration, short stature, Kayser-Fleischer ring, pyelonephritis, hypovolemia, hypoglycemia, polyuria, polydipsia, dehydration

Contributor Information and Disclosures

Author

Rajendra Bhimma, MB, ChB, MD, DCH (SA), FCP (Paeds)(SA), MMed (Natal), Associate Professor of Pediatrics, Principal Specialist, Department of Pediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, South Africa
Rajendra Bhimma, MB, ChB, MD, DCH (SA), FCP (Paeds)(SA), MMed (Natal) is a member of the following medical societies: American Association for the Advancement of Science, International Pediatric Transplant Association, International Society of Nephrology, South African Medical Association, South African Paediatric Association, and South African Transplant Society
Disclosure: Nothing to disclose.

Medical Editor

Laurence Finberg, MD, Clinical Professor, Department of Pediatrics, University of California at San Francisco and Stanford University
Laurence Finberg, MD is a member of the following medical societies: American Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

Luther Travis, MD, William W Glauser Professor of Pediatrics and Pediatric Nephrology, Department of Pediatrics, Divisions of Nephrology and Diabetes, University of Texas Medical Branch and Children's Hospital
Luther Travis, MD is a member of the following medical societies: Alpha Omega Alpha, American Federation for Medical Research, International Society of Nephrology, and Texas Pediatric Society
Disclosure: Nothing to disclose.

CME Editor

Howard Trachtman, MD, Program Director, Pediatrics Research, Schneider Children's Hospital, Department of Pediatrics, Division of Nephrology, Professor, Albert Einstein College of Medicine
Howard Trachtman, MD is a member of the following medical societies: American Society of Hypertension, American Society of Nephrology, American Society of Pediatric Nephrology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Chief Editor

Craig B Langman, MD, The Isaac A Abt, MD, Professor of Kidney Diseases, Feinberg School of Medicine, Northwestern University; Division Head of Kidney Diseases, Children's Memorial Hospital, Chicago
Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, and International Society of Nephrology
Disclosure: Amgen Grant/research funds None; Altus Pharmaceuticals Grant/research funds None; Genzyme Grant/research funds None; Merck Grant/research funds None; NIH Grant/research funds None

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.