eMedicine Specialties > Pediatrics: General Medicine > Nephrology
Renal Glucosuria: Treatment & Medication
Updated: Feb 17, 2009
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
Treatment
Medical Care
Benign renal glucosuria is a self-limiting process and requires no special medical care. If other associated findings suggest tubular disorders, then other interventions are required.
Consultations
Consultation with a pediatric nephrologist may be appropriate.
Diet
No special dietary instructions are required. In a very rare case of extremely large amounts of urinary glucose, glucose or another carbohydrate may be required during episodes of great physical activity to prevent hypoglycemia.
Medication
No treatment is required for benign renal glucosuria.
More on Renal Glucosuria |
| Overview: Renal Glucosuria |
| Differential Diagnoses & Workup: Renal Glucosuria |
Treatment & Medication: Renal Glucosuria |
| Follow-up: Renal Glucosuria |
| References |
| « Previous Page | Next Page » |
References
Calado J, Soto K, Clemente C, Correia P, Rueff J. Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria. Hum Genet. Feb 2004;114(3):314-6. [Medline].
Calado J, Loeffler J, Sakallioglu O, Gok F, Lhotta K, Barata J. Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting. Kidney Int. Mar 2006;69(5):852-5. [Medline].
Calado J, Sznajer Y, Metzger D, Rita A, Hogan MC, Kattamis A. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrol Dial Transplant. Dec 2008;23(12):3874-9. [Medline].
Brodehl J, Franken A, Gellissen K. Maximal tubular reabsorption of glucose in infants and children. Acta Paediatr Scand. Jul 1972;61(4):413-20. [Medline].
Crombie DL. Incidence of glycosuria and diabetes. Proc R Soc Med. 1961;55:205.
Desjeuz JF, Turk E, Wright E. Congenital selective Na+ D-glucose co-transport defects leading to renal glycosuria and congenital selective intestinal malabsorption of glucose and galactose. In: The Metabolic and Molecular Basis of Inherited Diseases. 1995:3563-80.
Elias LJ, Longo N. Glucose transporters. Ann Rev Med. 1992;43:377-393. [Medline].
Elsas LJ, Rosenberg LE. Familial renal glycosuria: a genetic reappraisal of hexose transport by kidney and intestine. J Clin Invest. Oct 1969;48(10):1845-54. [Medline]. [Full Text].
Francis J, Zhang J, Farhi A, Carey H, Geller DS. A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. Nephrol Dial Transplant. Nov 2004;19(11):2893-5. [Medline].
Francis J, Zhang J, Farhi A, et al. A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. Nephrol Dial Transplant. Nov 2004;19(11):2893-5. [Medline].
Harkness J. Prevalence of glycosuria and diabetes mellitus. A comprehensive survey in an urban community. Br Med J. Jun 2 1962;5291:1503-7. [Medline].
Jackson WP, Marine N, Vinik AI. The significance of glycosuria. Lancet. May 4 1968;1(7549):933-6. [Medline].
Jones DP, Chesney RW. Development of tubular function. Clin Perinatol. Mar 1992;19(1):33-57. [Medline].
Keller DM. Glucose excretion in man and dog. Nephron. 1968;5(1):43-66. [Medline]. [Full Text].
Kleta R, Stuart C, Gill FA, Gahl WA. Renal glucosuria due to SGLT2 mutations. Mol Genet Metab. May 2004;82(1):56-8. [Medline].
Magen D, Sprecher E, Zelikovic I, Skorecki K. A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessiverenal glucosuria and aminoaciduria. Kidney Int. Jan 2005;67(1):34-41. [Medline].
Marble A. Nondiabetic melituria. In: Marble A, White P, Bradley RF, et al eds. Joslin's Diabetes Mellitus. 11th ed. Philadelphia, Pa: BC Decker Inc; 1971.
Pajor AM, Wright EM. Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family. J Biol Chem. Feb 25 1992;267(6):3557-60. [Medline].
Renal glycosuria. In: Brodehl J, Edelmann CM Jr, eds. Pediatric Kidney Disease. 2nd ed. Little Brown & Co; 1992:1801-10.
Santer R, Kinner M, Lassen CL, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol. Nov 2003;14(11):2873-82. [Medline]. [Full Text].
Simmons RA. Cell glucose transport and glucose handling during fetal and neonatal development. In: Rolin RA, Fox WW, eds. Fetal and Neonatal Physiology. 2nd ed. Philadelphia, PA: WB Saunders Co; 1998:585-90.
Spitzer A. The developing kidney and the process of growth. In: The Seldin DW, Giebisch G, eds. Kidney: Physiology and Pathophysiology. 1985.
Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol. Sep 1992;263(3 Pt 2):F459-65. [Medline].
Woolf LI, Goodwin BL, Phelps CE. T-m-limited renal tubular reabsorption and the genetics of renal glucosuria. J Theor Biol. May 1966;11(1):10-21. [Medline].
Wu CJ. Transient renal glycosuria in a patient with acute pyelonephritis. Intern Med. Jun 2001;40(6):519-21. [Medline].
Zelikovic I. Aminoaciduria and glycosuria. In: Barratt TM, Avner ED, Harmon WE, eds. Pediatric Nephrology. 4th ed. Lippincott Williams & Wilkins; 1999:507-27.
Further Reading
Keywords
renal glucosuria, renal glycosuria, glucose in urine, familial renal glycosuria, FRG, Fanconi syndrome, cystinosis, Wilson disease, hereditary tyrosinemia, oculocerebrorenal syndrome, Lowe syndrome, hyperglycemia, diabetes mellitus, hypophosphatemic rickets, dehydration, short stature, Kayser-Fleischer ring, pyelonephritis, hypovolemia, hypoglycemia, polyuria, polydipsia, dehydration
Treatment & Medication: Renal Glucosuria