Biotin Deficiency Follow-up
- Author: Noah S Scheinfeld, MD, JD, FAAD; Chief Editor: Jatinder Bhatia, MBBS more...
Further Inpatient Care
Inpatient care should not be required to treat patients with biotin deficiency.
Further Outpatient Care
Profound biotinidase deficiency can be detected with newborn screening.
Follow-up visits should be scheduled every few weeks to ensure that all of the signs and symptoms of the condition have resolved with therapy.
Thereafter, no additional outpatient care should be required.
Inpatient & Outpatient Medications
Administer biotin in patients with biotin deficiency (see Medication).
In addition, antifungal medications may be required to treat patients with fungal infections that develop during the course of biotin deficiency.
Deterrence/Prevention
Instruct patients to avoid consuming raw eggs.
Include biotin in total parental nutrition (TPN) solutions.
Observe patients who are receiving prolonged oral antibiotic treatment or anticonvulsant medications because signs and symptoms suggestive of biotin deficiency may develop. If such signs or symptoms develop, administer supplemental biotin either intravenously or intramuscularly.
Complications
Fungal infections are a concern.
Prognosis
The prognosis is excellent.
Once biotin therapy has been initiated with the proper dosage, signs and symptoms of biotin deficiency should begin to disappear within 3-5 weeks and completely resolve within 2-3 months.
Patient Education
Instruct patients regarding the dangers of consuming raw eggs.
Instruct patients who are receiving certain anticonvulsant medications regarding signs and symptoms of biotin deficiency so that they can immediately seek medical attention should signs and symptoms develop.
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