Pediatric Pellagra Medication

  • Author: Simon S Rabinowitz, MD, PhD; Chief Editor: Jatinder Bhatia, MBBS   more...
 
Updated: Jul 8, 2010
 

Vitamins

Class Summary

These are organic substances required by the body in small amounts for various metabolic processes. Vitamins may be synthesized in small or insufficient amounts in the body or not synthesized at all, thus requiring supplementation.

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Niacin (Vitamin B-3)

 

Source of niacin used in tissue respiration, lipid metabolism, and glycogenolysis. Exogenous administration cures the syndrome and, within the dosage levels prescribed, is not associated with uncomfortable flushing observed with niacin administration in other conditions (eg, hypercholesterolemia).

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Contributor Information and Disclosures
Author

Simon S Rabinowitz, MD, PhD  Professor of Clinical Pediatrics, New York Medical College; Chairman, Chief and Medical Administrator, Department of Pediatrics, Chief, Pediatric Gastroenterology and Nutrition, Richmond University Medical Center

Simon S Rabinowitz, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Association for the Advancement of Science, American College of Gastroenterology, American Gastroenterological Association, American Medical Association, New York Academy of Sciences, North American Society for Pediatric Gastroenterology and Nutrition, Phi Beta Kappa, and Sigma Xi

Disclosure: Nothing to disclose.

Coauthor(s)

Valeriya Feygina, MD, PhD  Resident Physician, Department of Pediatrics, Richmond University Medical Center

Disclosure: Nothing to disclose.

Sujana Reddy, MD  Staff Physician, Department of Pediatrics, Richmond University Medical Center, Staten Island

Sujana Reddy, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Specialty Editor Board

Steven M Schwarz, MD, FAAP, FACN, AGAF  Professor of Pediatrics, Children's Hospital at Downstate, SUNY-Downstate Medical Center

Steven M Schwarz, MD, FAAP, FACN, AGAF is a member of the following medical societies: American Academy of Pediatrics, American College of Nutrition, American College of Physician Executives, American Gastroenterological Association, American Pediatric Society, Gastroenterology Research Group, New York Academy of Medicine, North American Society for Pediatric Gastroenterology and Nutrition, and Society for Pediatric Research

Disclosure: Curemark, LLC Consulting fee Board membership; Centocor, Inc. Grant/research funds Independent contractor; Johnson & Johnson, Inc. Grant/research funds Independent contractor

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Pharmacy Editor, eMedicine

Disclosure: Nothing to disclose.

Jatinder Bhatia, MBBS  Professor of Pediatrics, Chief, Section of Neonatology, Department of Pediatrics, Medical College of Georgia

Jatinder Bhatia, MBBS is a member of the following medical societies: American Academy of Pediatrics, American Association for the Advancement of Science, American Dietetic Association, American Pediatric Society, American Society for Clinical Nutrition, American Society for Parenteral and Enteral Nutrition, Society for Pediatric Research, and Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Merrily P M Poth, MD  Professor, Department of Pediatrics and Neuroscience, Uniformed Services University of the Health Sciences

Merrily P M Poth, MD is a member of the following medical societies: American Academy of Pediatrics, Endocrine Society, and Lawson-Wilkins Pediatric Endocrine Society

Disclosure: Nothing to disclose.

Chief Editor

Jatinder Bhatia, MBBS  Professor of Pediatrics, Chief, Section of Neonatology, Department of Pediatrics, Medical College of Georgia

Jatinder Bhatia, MBBS is a member of the following medical societies: American Academy of Pediatrics, American Association for the Advancement of Science, American Dietetic Association, American Pediatric Society, American Society for Clinical Nutrition, American Society for Parenteral and Enteral Nutrition, Society for Pediatric Research, and Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

References

  1. Rajakumar K. Pellagra in the United States: a historical perspective. South Med J. Mar 2000;93(3):272-7. [Medline].

  2. Reichman O, Sobel JD. Vulvovaginal pellagra and lichen sclerosus complicating carcinoid syndrome. Obstet Gynecol. Feb 2009;113(2 Pt 2):543-5. [Medline].

  3. Okan G, Yaylaci S, Alzafer S. Pellagra: will we see it more frequently?. J Eur Acad Dermatol Venereol. Mar 2009;23(3):365-6. [Medline].

  4. Seal AJ, Creeke PI, Dibari F, Cheung E, Kyroussis E, Semedo P. Low and deficient niacin status and pellagra are endemic in postwar Angola. Am J Clin Nutr. Jan 2007;85(1):218-24. [Medline].

  5. Spivak JL, Jackson DL. Pellagra: an analysis of 18 patients and a review of the literature. Johns Hopkins Med J. Jun 1977;140(6):295-309. [Medline].

  6. Dumitrescu C, Lichiardopol R. Particular features of clinical pellagra. Rom J Intern Med. Apr-Jun 1994;32(2):165-70. [Medline].

  7. Nogueira A, Duarte AF, Magina S, Azevedo F. Pellagra associated with esophageal carcinoma and alcoholism. Dermatol Online J. 2009;15(5):8. [Medline].

  8. Broer S, Cavanaugh JA, Rasko JE. Neutral amino acid transport in epithelial cells and its malfunction in Hartnup disorder. Biochem Soc Trans. Feb 2005;33(Pt 1):233-6. [Medline].

  9. Beretich GR Jr. Do high leucine/low tryptophan dieting foods (yogurt, gelatin) with niacin supplementation cause neuropsychiatric symptoms (depression) but not dermatological symptoms of pellagra?. Med Hypotheses. 2005;65(3):628-9. [Medline].

  10. Murray MF, Langan M, MacGregor RR. Increased plasma tryptophan in HIV-infected patients treated with pharmacologic doses of nicotinamide. Nutrition. Jul-Aug 2001;17(7-8):654-6. [Medline].

  11. Tremeschin MH, Cervi MC, Camelo Junior JS, et al. Niacin nutritional status in HIV type 1-positive children: preliminary data. J Pediatr Gastroenterol Nutr. May 2007;44(5):629-33. [Medline].

  12. Creeke PI, Dibari F, Cheung E, et al. Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra. J Nutr. Sep 2007;137(9):2013-7. [Medline].

  13. Serdaru M, Hausser-Hauw C, Laplane D, et al. The clinical spectrum of alcoholic pellagra encephalopathy. A retrospective analysis of 22 cases studied pathologically. Brain. Aug 1988;111 ( Pt 4):829-42. [Medline].

  14. Barakat MR. Pellagra. Monogr Ser World Health Organ. 1976;(62):126-35. [Medline].

  15. Barness LA. Niacin deficiency. In: Nelson Textbook of Pediatrics. 14th ed. Philadelphia, PA: WB Saunders; 1992:137-8.

  16. Carpenter KJ. Pellagra. In: Benchmark Papers in Biochemistry. Vol 2. Stroudsburg, Pennsylvania: Hutchinson Ross Publishing Company; 1981:1-391.

  17. Etheridge EW. The Butterfly Caste: A Social History of Pellagra in the South. Wesport, CT: Greenwood Publishing Co; 1972:1-278.

  18. Goldsmith GA. Vitamin B complex. Thiamine, riboflavin, niacin, folic acid (folacin), vitamin B12, biotin. Prog Food Nutr Sci. 1975;1(9):559-609. [Medline].

  19. Greene HL. Disorders of the water-soluble vitamin B-complex and vitamin C. In: Suskind RM, Lewinter-Suskind L, eds. Textbook of Pediatric Nutrition. 1993:73-89.

  20. Hegyi J, Schwartz RA, Hegyi V. Pellagra: dermatitis, dementia, and diarrhea. Int J Dermatol. Jan 2004;43(1):1-5. [Medline].

  21. Hendricks WM. Pellagra and pellagralike dermatoses: etiology, differential diagnosis, dermatopathology, and treatment. Semin Dermatol. Dec 1991;10(4):282-92. [Medline].

  22. Jagielska G, Tomaszewicz-Libudzic EC, Brzozowska A. Pellagra: a rare complication of anorexia nervosa. Eur Child Adolesc Psychiatry. Oct 2007;16(7):417-20. [Medline].

  23. Marks HM. Epidemiologists explain pellagra: gender, race, and political economy in the work of Edgar Sydenstricker. J Hist Med Allied Sci. Jan 2003;58(1):34-55. [Medline].

  24. Sakai K, Nakajima T, Fukuhara N. A suspected case of alcoholic pellagra encephalopathy with marked response to niacin showing myoclonus and ataxia as chief complaints. No To Shinkei. Feb 2006;58(2):141-4. [Medline].

  25. Shah GM, Shah RG, Veillette H, et al. Biochemical assessment of niacin deficiency among carcinoid cancer patients. Am J Gastroenterol. Oct 2005;100(10):2307-14. [Medline].

  26. Truswell AS. Niacin (nicotinic acid and nicotinamide). In: Davidson's Principles and Practice of Medicine. 1981:113-6.

 
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