eMedicine Specialties > Pediatrics: General Medicine > Oncology

Astrocytoma: Multimedia

Author: Tobey MacDonald, MD, Clinical Director of Neuro-Oncology, Children's Hospital National Medical Center; Associate Professor, Department of Pediatric Hematology-Oncology, George Washington University
Coauthor(s): Roger J Packer, MD, Executive Director, Neuroscience and Behavioral Medicine, Director, Brain Tumor Institute, Children's National Medical Center; Professor of Neurology and Pediatrics, The George Washington University
Contributor Information and Disclosures

Updated: Feb 11, 2009

Multimedia

This MRI shows a juvenile pilocytic astrocytoma o...
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Media file 1: This MRI shows a juvenile pilocytic astrocytoma of the cerebellum.
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This MRI shows a juvenile pilocytic astrocytoma o...

This MRI shows a juvenile pilocytic astrocytoma of the cerebellum.

This MRI shows a supratentorial glioblastoma mult...
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Media file 2: This MRI shows a supratentorial glioblastoma multiforme.
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This MRI shows a supratentorial glioblastoma mult...

This MRI shows a supratentorial glioblastoma multiforme.

This section displays the typical biphasic patter...
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Media file 3: This section displays the typical biphasic pattern of a juvenile pilocytic astrocytoma, consisting of dense, relatively anuclear, fibrillar areas alternating with looser cystic fields.
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This section displays the typical biphasic patter...

This section displays the typical biphasic pattern of a juvenile pilocytic astrocytoma, consisting of dense, relatively anuclear, fibrillar areas alternating with looser cystic fields.

This section displays the high cellularity, mitos...
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Media file 4: This section displays the high cellularity, mitosis, and nuclear atypia characteristic of an anaplastic astrocytoma (grade III).
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This section displays the high cellularity, mitos...

This section displays the high cellularity, mitosis, and nuclear atypia characteristic of an anaplastic astrocytoma (grade III).

This section displays a typical field of a gliobl...
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Media file 5: This section displays a typical field of a glioblastoma multiforme (grade IV) with pseudopalisading neovascularity, nuclear atypia, numerous mitoses, and areas of hemorrhage.
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This section displays a typical field of a gliobl...

This section displays a typical field of a glioblastoma multiforme (grade IV) with pseudopalisading neovascularity, nuclear atypia, numerous mitoses, and areas of hemorrhage.

More on Astrocytoma

Overview: Astrocytoma
Differential Diagnoses & Workup: Astrocytoma
Treatment & Medication: Astrocytoma
Follow-up: Astrocytoma
Multimedia: Astrocytoma
References
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References

  1. Chintagumpala MM, Friedman HS, Stewart CF, et al. A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group. J Neurooncol. Apr 2006;77(2):193-8. [Medline].

  2. Geyer JR, Sposto R, Jennings M, et al. Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group. J Clin Oncol. Oct 20 2005;23(30):7621-31. [Medline].

  3. Pollack IF, Hamilton RL, Sobol RW, et al. O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort. J Clin Oncol. Jul 20 2006;24(21):3431-7. [Medline].

  4. Bouffet E, Jakacki R, Goldman S, et al. Phase II Study of weekly vinblastine in recurrent/refractory pediatric low-grade gliomas. Neuro-Oncology. 2008;10(3):450.

  5. Bredel M, Pollack IF, Hamilton RL, James CD. Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood. Clin Cancer Res. Jul 1999;5(7):1786-92. [Medline].

  6. Cokgor I, Friedman AH, Friedman HS. Gliomas. Eur J Cancer. Nov 1998;34(12):1910-5; discussion 1916-8. [Medline].

  7. Fernandez C, Figarella-Branger D, Girard N, et al. Pilocytic astrocytomas in children: prognostic factors--a retrospective study of 80 cases. Neurosurgery. Sep 2003;53(3):544-53; discussion 554-5. [Medline].

  8. Finlay JL, Boyett JM, Yates AJ, et al. Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. J Clin Oncol. Jan 1995;13(1):112-23. [Medline].

  9. Finlay JL, Wisoff JH. The impact of extent of resection in the management of malignant gliomas of childhood. Childs Nerv Syst. Nov 1999;15(11-12):786-8. [Medline].

  10. Gilbertson RJ, Hill DA, Hernan R, et al. ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. Clin Cancer Res. Sep 1 2003;9(10 Pt 1):3620-4. [Medline].

  11. Grill J, Couanet D, Cappelli C, et al. Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma. Ann Neurol. Mar 1999;45(3):393-6. [Medline].

  12. Gururangan S, Fisher MJ, Allen JC, Herndon JE 2nd, Quinn JA, Reardon DA, et al. Temozolomide in children with progressive low-grade glioma. Neuro Oncol. Apr 2007;9(2):161-8. [Medline].

  13. Guthrie BL, Laws ER Jr. Supratentorial low-grade gliomas. Neurosurg Clin N Am. Jan 1990;1(1):37-48. [Medline].

  14. Huncharek M, Wheeler L, McGarry R, Geschwind JF. Chemotherapy response rates in recurrent/progressive pediatric glioma; results of a systematic review. ALYSIS. Jul-Aug 1999;19(4C):3569-74. [Medline].

  15. Jacobson DM. Gliomas of the anterior visual pathways. Neurosurg Clin N Am. Oct 1999;10(4):683-98, ix. [Medline].

  16. Khatua S, Peterson KM, Brown KM, et al. Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res. Apr 15 2003;63(8):1865-70. [Medline].

  17. Khaw SL, Coleman LT, Downie PA, Heath JA, Ashley DM. Temozolomide in pediatric low-grade glioma. Pediatr Blood Cancer. Nov 2007;49(6):808-11. [Medline].

  18. Komotar RJ, Mocco J, Carson BS, et al. Pilomyxoid astrocytoma: a review. MedGenMed. 2004;6(4):42. [Medline].

  19. Kuo DJ, Weiner HL, Wisoff J, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol. May 2003;25(5):372-8. [Medline].

  20. Lafay-Cousin L, Holm S, Qaddoumi I, et al. Weekly vinblastine in pediatric low-grade glioma patients with carboplatin allergic reaction. Cancer. Jun 15 2005;103(12):2636-42. [Medline].

  21. MacDonald TJ, Arenson EB, Ater J, et al. Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933. Cancer. Dec 15 2005;104(12):2862-71. [Medline].

  22. Nadkarni TD, Rekate HL. Pediatric intramedullary spinal cord tumors. Critical review of the literature. Childs Nerv Syst. Jan 1999;15(1):17-28. [Medline].

  23. Nicholson HS, Krailo M, Ames MM, et al. Phase I study of temozolomide in children and adolescents with recurrent solid tumors: a report from the Children's Cancer Group. J Clin Oncol. Sep 1998;16(9):3037-43. [Medline].

  24. Packer RJ. Brain tumors in children. Arch Neurol. Apr 1999;56(4):421-5. [Medline].

  25. Pencalet P, Maixner W, Sainte-Rose C, et al. Benign cerebellar astrocytomas in children. J Neurosurg. Feb 1999;90(2):265-73. [Medline].

  26. Pollack IF. The role of surgery in pediatric gliomas. J Neurooncol. May 1999;42(3):271-88. [Medline].

  27. Pollack IF, Boyett JM, Finlay JL. Chemotherapy for high-grade gliomas of childhood. Childs Nerv Syst. Oct 1999;15(10):529-44. [Medline].

  28. Pollack IF, Finkelstein SD, Woods J, et al. Expression of p53 and prognosis in children with malignant gliomas. N Engl J Med. Feb 7 2002;346(6):420-7. [Medline].

  29. Prados MD, Edwards MS, Rabbitt J, Lamborn K, Davis RL, Levin VA. Treatment of pediatric low-grade gliomas with a nitrosourea-based multiagent chemotherapy regimen. J Neurooncol. May 1997;32(3):235-41. [Medline].

  30. Reddy AT, Packer RJ. Chemotherapy for low-grade gliomas. Childs Nerv Syst. Oct 1999;15(10):506-13. [Medline].

  31. Rubin G, Michowitz S, Horev G, et al. Pediatric brain stem gliomas: an update. Childs Nerv Syst. Apr-May 1998;14(4-5):167-73. [Medline].

  32. Sharif S, Ferner R, Birch JM, et al. Second primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy. J Clin Oncol. Jun 1 2006;24(16):2570-5. [Medline].

  33. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. Mar 10 2005;352(10):987-96. [Medline].

  34. Thorarinsdottir HK, Rood B, Kamani N, et al. Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue. Pediatr Blood Cancer. Feb 2 2006;[Medline].

  35. Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol. Oct 20 2007;25(30):4722-9. [Medline].

  36. Wisoff JH, Boyett JM, Berger MS, et al. Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children's Cancer Group trial no. CCG-945. J Neurosurg. Jul 1998;89(1):52-9. [Medline].

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Further Reading

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Keywords

astrocytoma, glioma, brain tumors, pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, glioblastoma multiforme, Li-Fraumeni syndrome, neurofibromatosis, NF1, leukemia, intracranial pressure, ICP, seizures, hypothalamic tumor, growth hormone deficiency, diabetes insipidus, precocious puberty, spinal astrocytomas, monoparesis, quadriparesis, tuberous sclerosis, Li-Fraumeni syndrome

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Contributor Information and Disclosures

Author

Tobey MacDonald, MD, Clinical Director of Neuro-Oncology, Children's Hospital National Medical Center; Associate Professor, Department of Pediatric Hematology-Oncology, George Washington University
Tobey MacDonald, MD is a member of the following medical societies: American Association for Cancer Research, Children's Oncology Group, Pediatric Brain Tumor Consortium, and Society for Neuro-Oncology
Disclosure: Nothing to disclose.

Coauthor(s)

Roger J Packer, MD, Executive Director, Neuroscience and Behavioral Medicine, Director, Brain Tumor Institute, Children's National Medical Center; Professor of Neurology and Pediatrics, The George Washington University
Roger J Packer, MD is a member of the following medical societies: American Academy of Neurology, American Neurological Association, American Pediatric Society, Child Neurology Society, Children's Oncology Group, Neurofibromatosis Clinical Trials Consortium, Pediatric Brain Tumor Consortium, and Society for Neuro-Oncology
Disclosure: Nothing to disclose.

Medical Editor

Samuel Gross, MD, Professor Emeritus, Department of Pediatrics, University of Florida; Clinical Professor, Department of Pediatrics, University of North Carolina; Adjunct Professor, Department of Pediatrics, Duke University
Samuel Gross, MD is a member of the following medical societies: American Association for Cancer Research, American Society for Blood and Marrow Transplantation, American Society of Clinical Oncology, American Society of Hematology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

Timothy P Cripe, MD, PhD, Professor of Pediatric Hematology/Oncology, University of Cincinnati; Director, Translational Research Trials Office, Department of Pediatrics, Cincinnati Children's Hospital Medical Center
Timothy P Cripe, MD, PhD is a member of the following medical societies: American Association for the Advancement of Science, American Pediatric Society, American Society of Hematology, American Society of Pediatric Hematology/Oncology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

CME Editor

David Pallares, MD, Clinical Assistant Professor, Department of Pediatrics, Division of Allergy and Immunology, University of Louisville
David Pallares, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology
Disclosure: Nothing to disclose.

Chief Editor

Max J Coppes, MD, PhD, MBA, Executive Director, Center for Cancer and Blood Disorders, Children's National Medical Center; Professor of Medicine, Oncology, and Pediatrics, Georgetown University
Max J Coppes, MD, PhD, MBA is a member of the following medical societies: American Association for Cancer Research, American Society of Pediatric Hematology/Oncology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

 
 
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