eMedicine Specialties > Pediatrics: General Medicine > Oncology
Non-Hodgkin Lymphoma: Multimedia
Updated: Dec 5, 2008
Multimedia
![]() | Media file 1: Incidence of lymphoma as a function of age per 100,000 population. Data are from the Surveillance, Epidemiology, and End Results (SEER) for 1990-1994. |
![]() | Media file 2: Massive mediastinal T-lymphoblastic lymphoma. Note compression of the left mainstem bronchus and the pulmonary atelectasis. |
More on Non-Hodgkin Lymphoma |
| Overview: Non-Hodgkin Lymphoma |
| Differential Diagnoses & Workup: Non-Hodgkin Lymphoma |
| Treatment & Medication: Non-Hodgkin Lymphoma |
| Follow-up: Non-Hodgkin Lymphoma |
Multimedia: Non-Hodgkin Lymphoma |
| References |
| « Previous Page |
References
Shad A, Magrath I. Malignant non-Hodgkin's lymphomas in children. In: Principles and Practice of Pediatric Oncology. 1997:545-87.
Cancer in children (ages 0-14 and ages 0-19). In: Ries LA, Kosary CL, Hankey BF, eds. SEER Cancer Statistics Review, 1973-94. NIH publication 97-2789. Bethesda, Md: Cancer Statistics Branch, Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute; 1997:[Full Text].
Liu S, Semenciw R, Mao Y. Increasing incidence of non-Hodgkin's lymphoma in Canada, 1970-1996: age-period-cohort analysis. Hematol Oncol. 2003;21(2):57-66. [Medline].
Kadin ME, Sako D, Berliner N, Franklin W, Woda B, Borowitz M. Childhood Ki-1 lymphoma presenting with skin lesions and peripheral lymphadenopathy. Blood. Nov 1986;68(5):1042-9. [Medline]. [Full Text].
Kumar S, Pittaluga S, Raffeld M, Guerrera M, Seibel NL, Jaffe ES. Primary cutaneous CD30-positive anaplastic large cell lymphoma in childhood: report of 4 cases and review of the literature. Pediatr Dev Pathol. Jan-Feb 2005;8(1):52-60. [Medline].
Al-Tonbary Y, Abdel-Razek N, Zaghloul H, Metwaly S, El-Deek B, El-Shawaf R. HLA class II polymorphism in Egyptian children with lymphomas. Hematology. Apr 2004;9(2):139-45. [Medline].
Vadivelu MK, Damodaran S, Solomon J, Rajaseharan A. Distribution of ABO blood groups in acute leukaemias and lymphomas. Ann Hematol. Sep 2004;83(9):584-7. [Medline].
Quintana PJ, Delfino RJ, Korrick S, Ziogas A, Kutz FW, Jones EL. Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma. Environ Health Perspect. Jun 2004;112(8):854-61. [Medline]. [Full Text].
Zahm SH, Ward MH. Pesticides and childhood cancer. Environ Health Perspect. Jun 1998;106 Suppl 3:893-908. [Medline]. [Full Text].
Pearce MS, Cotterill SJ, Parker L. Fathers' occupational contacts and risk of childhood leukemia and non-hodgkin lymphoma. Epidemiology. May 2004;15(3):352-6. [Medline].
Hughes AM, Armstrong BK, Vajdic CM, Turner J, Grulich AE, Fritschi L. Sun exposure may protect against non-Hodgkin lymphoma: a case-control study. Int J Cancer. Dec 10 2004;112(5):865-71. [Medline].
Prosper F, Robledo C, Cuesta B, Rifon J, Borbolla JR, Pardo J. Incidence of non-Hodgkin's lymphoma in patients treated for Hodgkin's disease. Leuk Lymphoma. Feb 1994;12(5-6):457-62. [Medline].
Dietrich PY, Henry-Amar M, Cosset JM, Bodis S, Bosq J, Hayat M. Second primary cancers in patients continuously disease-free from Hodgkin's disease: a protective role for the spleen?. Blood. Aug 15 1994;84(4):1209-15. [Medline]. [Full Text].
Eguiguren JM, Ribeiro RC, Pui CH, Hancock ML, Pratt CB, Head DR. Secondary non-Hodgkin's lymphoma after treatment for childhood cancer. Leukemia. Oct 1991;5(10):908-11. [Medline].
Imai S, Sugiura M, Mizuno F, Ohigashi H, Koshimizu K, Chiba S. African Burkitt's lymphoma: a plant, Euphorbia tirucalli, reduces Epstein-Barr virus-specific cellular immunity. Anticancer Res. May-Jun 1994;14(3A):933-6. [Medline].
van den Bosch CA. Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter?. Lancet Oncol. Dec 2004;5(12):738-46. [Medline].
Goldsby RE, Carroll WL. The molecular biology of pediatric lymphomas. J Pediatr Hematol Oncol. Jul-Aug 1998;20(4):282-96. [Medline].
Lones MA, Sanger WG, Le Beau MM, Heerema NA, Sposto R, Perkins SL. Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents: a report from Children's Cancer Group Study CCG-E08. J Pediatr Hematol Oncol. Mar 2004;26(3):169-78. [Medline].
Garcia JL, Hernandez JM, Gutierrez NC, Flores T, Gonzalez D, Calasanz MJ. Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization study. Leukemia. Oct 2003;17(10):2016-24. [Medline].
Cayuela JM, Gardie B, Sigaux F. Disruption of the multiple tumor suppressor gene MTS1/p16(INK4a)/CDKN2 by illegitimate V(D)J recombinase activity in T-cell acute lymphoblastic leukemias. Blood. Nov 1 1997;90(9):3720-6. [Medline]. [Full Text].
Poirel HA, Cairo MS, Heerema NA, et al. Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international study. Leukemia. 2008;[Medline].
Liang X, Meech SJ, Odom LF, Bitter MA, Ryder JW, Hunger SP. Assessment of t(2;5)(p23;q35) translocation and variants in pediatric ALK+ anaplastic large cell lymphoma. Am J Clin Pathol. Apr 2004;121(4):496-506. [Medline].
Sandlund JT, Pui CH, Roberts WM, Santana VM, Morris SW, Berard CW. Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5)(p23;q35). Blood. Oct 15 1994;84(8):2467-71. [Medline]. [Full Text].
Depas G, De Barsy C, Jerusalem G, Hoyoux C, Dresse MF, Fassotte MF. 18F-FDG PET in children with lymphomas. Eur J Nucl Med Mol Imaging. Jan 2005;32(1):31-8. [Medline].
Schoder H, Noy A, Gonen M, Weng L, Green D, Erdi YE. Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin's lymphoma. J Clin Oncol. Jul 20 2005;23(21):4643-51. [Medline].
Mussolin L, Basso K, Pillon M, D'Amore ES, Lombardi A, Luzzatto L. Prospective analysis of minimal bone marrow infiltration in pediatric Burkitt's lymphomas by long-distance polymerase chain reaction for t(8;14)(q24;q32). Leukemia. Mar 2003;17(3):585-9. [Medline].
Sabesan V, Cairo MS, Lones MA, Perkins SL, Morris E, Sposto R. Assessment of minimal residual disease in childhood non-hodgkin lymphoma by polymerase chain reaction using patient-specific primers. J Pediatr Hematol Oncol. Feb 2003;25(2):109-13. [Medline].
Hutchison RE, Finch C, Kepner J, Fuller C, Bowman P, Link M. Burkitt lymphoma is immunophenotypically different from Burkitt-like lymphoma in young persons. Ann Oncol. 2000;11 Suppl 1:35-8. [Medline].
Bovio IM, Allan RW. The expression of myeloid antigens CD13 and/or CD33 is a marker of ALK+ anaplastic large cell lymphomas. Am J Clin Pathol. 2008;130(4):628-34. [Medline].
Murphy SB. Classification, staging and end results of treatment of childhood non-Hodgkin's lymphomas: dissimilarities from lymphomas in adults. Semin Oncol. Sep 1980;7(3):332-9. [Medline].
Hochberg J, Cairo MS. Rasburicase: future directions in tumor lysis management. Expert Opin Biol Ther. 2008;8(10):1595-604. [Medline].
Mora J, Filippa DA, Qin J, Wollner N. Lymphoblastic lymphoma of childhood and the LSA2-L2 protocol: the 30-year experience at Memorial-Sloan-Kettering Cancer Center. Cancer. Sep 15 2003;98(6):1283-91. [Medline].
Tubergen DG, Krailo MD, Meadows AT, Rosenstock J, Kadin M, Morse M. Comparison of treatment regimens for pediatric lymphoblastic non-Hodgkin's lymphoma: a Childrens Cancer Group study. J Clin Oncol. Jun 1995;13(6):1368-76. [Medline].
Reiter A, Schrappe M, Parwaresch R, Henze G, Muller-Weihrich S, Sauter S. Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Munster Group. J Clin Oncol. Feb 1995;13(2):359-72. [Medline].
Abromowitch M, Sposto R, Perkins S, et al. Shortened intensified multi-agent chemotherapy and non-cross resistant maintenance therapy for advanced lymphoblastic lymphoma in children and adolescents: report from the Children's Oncology Group. Br J Haematol. 2008;143(2):261-7. [Medline].
Gerrard M, Cairo MS, Weston C, Auperin A, Pinkerton R, Lambilliote A, et al. Excellent survival following two courses of COPAD chemotherapy in children and adolescents with resected localized B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international study. Br J Haematol. 2008;141(6):840-7. [Medline].
Patte C, Auperin A, Gerrard M, et al. Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients. Blood. 2007;109(7):2773-80. [Medline].
Cairo MS, Gerrard M, Sposto R, et al. Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents. Blood. 2007;109(7):2736-43. [Medline].
Woessmann W, Seidemann K, Mann G, Zimmermann M, Burkhardt B, Oschlies I. The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95. Blood. Feb 1 2005;105(3):948-58. [Medline].
Lones MA, Perkins SL, Sposto R, Kadin ME, Kjeldsberg CR, Wilson JF. Large-cell lymphoma arising in the mediastinum in children and adolescents is associated with an excellent outcome: a Children's Cancer Group report. J Clin Oncol. Nov 15 2000;18(22):3845-53. [Medline].
Raetz E, Perkins S, Davenport V, Cairo MS. B large-cell lymphoma in children and adolescents. Cancer Treat Rev. Apr 2003;29(2):91-8. [Medline].
Seidemann K, Tiemann M, Lauterbach I, Mann G, Simonitsch I, Stankewitz K. Primary mediastinal large B-cell lymphoma with sclerosis in pediatric and adolescent patients: treatment and results from three therapeutic studies of the Berlin-Frankfurt-Münster Group. J Clin Oncol. May 1 2003;21(9):1782-9. [Medline].
Weinstein HJ, Lack EE, Cassady JR. APO therapy for malignant lymphoma of large cell "histiocytic" type of childhood: analysis of treatment results for 29 patients. Blood. Aug 1984;64(2):422-6. [Medline].
Laver JH, Mahmoud H, Pick TE, Hutchinson RE, Weinstein HJ, Schwenn M. Results of a randomized phase III trial in children and adolescents with advanced stage diffuse large cell non Hodgkin's lymphoma: a Pediatric Oncology Group study. Leuk Lymphoma. Jul 2001;42(3):399-405. [Medline].
Reiter A, Schrappe M, Tiemann M, Parwaresch R, Zimmermann M, Yakisan E. Successful treatment strategy for Ki-1 anaplastic large-cell lymphoma of childhood: a prospective analysis of 62 patients enrolled in three consecutive Berlin-Frankfurt-Munster group studies. J Clin Oncol. May 1994;12(5):899-908. [Medline].
Seidemann K, Tiemann M, Schrappe M, Yakisan E, Simonitsch I, Janka-Schaub G. Short-pulse B-non-Hodgkin lymphoma-type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the Berlin-Frankfurt-Münster Group Trial NHL-BFM 90. Blood. Jun 15 2001;97(12):3699-706. [Medline]. [Full Text].
Laver JH, Kraveka JM, Hutchison RE, Chang M, Kepner J, Schwenn M. Advanced-stage large-cell lymphoma in children and adolescents: results of a randomized trial incorporating intermediate-dose methotrexate and high-dose cytarabine in the maintenance phase of the APO regimen: a Pediatric Oncology Group phase III trial. J Clin Oncol. Jan 20 2005;23(3):541-7. [Medline].
Brugières L, Quartier P, Le Deley MC, Pacquement H, Perel Y, Bergeron C. Relapses of childhood anaplastic large-cell lymphoma: treatment results in a series of 41 children--a report from the French Society of Pediatric Oncology. Ann Oncol. Jan 2000;11(1):53-8. [Medline]. [Full Text].
Jetsrisuparb A, Wiangnon S, Komvilaisak P, Kularbkaew C, Yutanawiboonchai W, Mairieng E. Rituximab combined with CHOP for successful treatment of aggressive recurrent, pediatric B-cell large cell non-Hodgkin's lymphoma. J Pediatr Hematol Oncol. Apr 2005;27(4):223-6. [Medline].
Kewalramani T, Zelenetz AD, Nimer SD, Portlock C, Straus D, Noy A. Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma. Blood. May 15 2004;103(10):3684-8. [Medline]. [Full Text].
Pilecki B, Kopiec P, Zajusz A, Podworski H, Szelc S, Skladowski K. Hyperfractionated radiotherapy for Burkitt-type lymphoma. Radiobiological aspects. Neoplasma. 1991;38(6):609-15. [Medline].
Muller HL, Klinkhammer-Schalke M, Kuhl J. Final height and weight of long-term survivors of childhood malignancies. Exp Clin Endocrinol Diabetes. 1998;106(2):135-9. [Medline].
Lahteenmaki PM, Sankila R, Pukkala E, Kyyronen P, Harila-Saari A. Scholastic achievement of children with lymphoma or Wilms tumor at the end of comprehensive education--a nationwide, register-based study. Int J Cancer. 2008;123 (10):2401-5. [Medline].
Haddy TB, Adde MA, McCalla J, Domanski MJ, Datiles M 3rd, Meehan SC. Late effects in long-term survivors of high-grade non-Hodgkin's lymphomas. J Clin Oncol. Jun 1998;16(6):2070-9. [Medline].
Hawkins MM, Wilson LM, Stovall MA, Marsden HB, Potok MH, Kingston JE. Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer. BMJ. Apr 11 1992;304(6832):951-8. [Medline]. [Full Text].
Nysom K, Holm K, Lipsitz SR, Mone SM, Colan SD, Orav EJ. Relationship between cumulative anthracycline dose and late cardiotoxicity in childhood acute lymphoblastic leukemia. J Clin Oncol. Feb 1998;16(2):545-50. [Medline].
Gilsanz V, Carlson ME, Roe TF, Ortega JA. Osteoporosis after cranial irradiation for acute lymphoblastic leukemia. J Pediatr. Aug 1990;117(2 Pt 1):238-44. [Medline].
Pulte D, Gondos A, Brenner H. Trends in 5- and 10-year survival after diagnosis with childhood hematologic malignancies in the United States, 1990-2004. J Natl Cancer Inst. 2008;100(18):1301-9. [Medline].
Suzuki R, Kagami Y, Takeuchi K, et al. Prognostic significance of CD56 expression for ALK-positive and ALK-negative anaplastic large-cell lymphoma of T/null cell phenotype. Blood. 2000;96(9):2993-3000. [Medline].
Kube D, Hua TD, von Bonin F, et al. Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study. Clin Cancer Res. 2008;14 (12):3777-84. [Medline].
Lee JJ, Kim DH, Lee NY, et al. Interleukin-10 gene polymorphism influences the prognosis of T-cell non-Hodgkin lymphomas. Br J Haematol. 2007;137 (4):329-36. [Medline].
Attarbaschi A, Dworzak M, Steiner M, Urban C, Fink FM, Reiter A. Outcome of children with primary resistant or relapsed non-Hodgkin lymphoma and mature B-cell leukemia after intensive first-line treatment: a population-based analysis of the Austrian Cooperative Study Group. Pediatr Blood Cancer. Jan 2005;44(1):70-6. [Medline].
Smith SM, van Besien K, Carreras J, et al. Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. Biol Blood Marrow Transplant. 2008;14(8):904-12. [Medline].
Further Reading
Keywords
non-Hodgkin lymphoma, NHL, non-Hodgkin's lymphoma, lymphoblastic lymphoma, LL, T-lymphoblastic lymphoma, T-LL, BL, Burkitt lymphoma, Burkitt's lymphoma, non-Burkitt lymphoma, non-Burkitt's lymphoma, non Burkitt lymphoma, Burkitt-like lymphoma, BLL, malignant small noncleaved lymphoma, small noncleaved cell lymphoma, SNCCL, SNCC lymphoma, undifferentiated lymphoma, large cell lymphomas, large-cell lymphomas, LCLs, B-cell LCLs, B-cell lymphoma, B-cell large cell lymphomas, BLCLs
ALCLs, anaplastic LCLs, anaplastic large cell lymphomas, Ki-1+ lymphoma, Ki 1+ lymphoma, malignant anaplastic lymphoma, histiocytic lymphoma, immunoblastic lymphoma, myeloid lymphoma, lymphosarcoma, reticulum cell sarcoma, acute lymphoblastic lymphoma, ALL, common ALL antigen, CALLA, diffuse large cell lymphoma










Multimedia: Non-Hodgkin Lymphoma