Lymphoproliferative Disorders Follow-up

  • Author: Stuart S Winter, MD; Chief Editor: Robert J Arceci, MD, PhD   more...
 
Updated: Nov 24, 2009
 

Further Inpatient Care

  • Follow-up care of a child with lymphoproliferative disorder (LPD) can range from simple (eg, watchful observation) to very complex (bone marrow transplantation).
  • Coordinate with a team of subspecialists familiar with immunodeficiency disorders and the management of potentially toxic drug therapy.
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Inpatient & Outpatient Medications

  • Inpatient and outpatient drugs depend on the nature of the underlying immunodeficiency syndrome.
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Deterrence/Prevention

  • The best preventive measure is to correct the underlying immunodeficiency syndrome.
  • Children who have had a bone marrow transplant with an immunocompetent graft are unlikely to develop problems with a lymphoproliferative disorder.
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Prognosis

  • Lymphoproliferative disorders prognoses are determined by the prevalence of immunodeficiency in the patient.
  • Ordinarily, a favorable response in a relatively immunocompetent patient is a good prognostic factor for long-term survival. Lymphoproliferative disorders of low-grade histological features tend to remit with a reduction of immunosuppression, whereas higher-grade lymphoproliferative disorders require a more aggressive therapeutic approach and often require several cycles of CHOP therapy with close follow-up.
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Contributor Information and Disclosures
Author

Stuart S Winter, MD  Associate Professor, Department of Pediatrics, University of New Mexico Health Sciences Center

Stuart S Winter, MD is a member of the following medical societies: American Association for Cancer Research, American Society of Pediatric Hematology/Oncology, Children's Oncology Group, New Mexico Pediatric Society, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Specialty Editor Board

Kathleen M Sakamoto, MD, PhD  Professor and Chief, Division of Hematology-Oncology, Vice-Chair of Research, Mattel Children's Hospital at UCLA; Co-Associate Program Director of the Signal Transduction Program Area, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA and California Nanosystems Institute and Molecular Biology Institute, UCLA

Kathleen M Sakamoto, MD, PhD is a member of the following medical societies: American Society of Hematology, American Society of Pediatric Hematology/Oncology, International Society for Experimental Hematology, Society for Pediatric Research, and Western Society for Pediatric Research

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Pharmacy Editor, eMedicine

Disclosure: Nothing to disclose.

Timothy P Cripe, MD, PhD  Professor of Pediatrics, Division of Hematology/Oncology, University of Cincinnati College of Medicine; Clinical Director, Musculoskeletal Tumor Program, Co-Medical Director, Office for Clinical and Translational Research, Director of Pilot and Collaborative Clinical and Translational Studies Core, Center for Clinical and Translational Science and Training, Cincinnati Children's Hospital Medical Center

Timothy P Cripe, MD, PhD is a member of the following medical societies: American Association for the Advancement of Science, American Pediatric Society, American Society of Hematology, American Society of Pediatric Hematology/Oncology, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Samuel Gross, MD  Professor Emeritus, Department of Pediatrics, University of Florida; Clinical Professor, Department of Pediatrics, University of North Carolina; Adjunct Professor, Department of Pediatrics, Duke University

Samuel Gross, MD is a member of the following medical societies: American Association for Cancer Research, American Society for Blood and Marrow Transplantation, American Society of Clinical Oncology, American Society of Hematology, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Robert J Arceci, MD, PhD  King Fahd Professor of Pediatric Oncology, Professor of Pediatrics, Oncology and the Cellular and Molecular Medicine Graduate Program, Kimmel Comprehensive Cancer Center at Johns Hopkins University School of Medicine

Robert J Arceci, MD, PhD is a member of the following medical societies: American Association for Cancer Research, American Association for the Advancement of Science, American Pediatric Society, American Society of Hematology, and American Society of Pediatric Hematology/Oncology

Disclosure: Nothing to disclose.

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