Pediatric Otosclerosis Medication

  • Author: Peter S Roland, MD; Chief Editor: Glenn C Isaacson, MD, FACS, FAAP   more...
 
Updated: Dec 6, 2011
 

Medication Summary

Sodium fluoride and calcium are the only drugs used in the treatment of otosclerosis; however, because it is typically not apparent until late adolescence, studies in pediatrics have not been pursued.

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Mineral and vitamin supplements

Class Summary

Sodium fluoride is thought to mature the active focus of otospongiosis and to limit progression of the disease, especially sensorineural hearing loss (SNHL).

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Sodium fluoride (Fluoritab, Luride, Pediaflor)

 

Fluoride is an element essential for the development of healthy teeth and bones.

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Vitamin D

 

Stimulates calcium and phosphate absorption from small intestine and promotes calcium release from bone into blood.

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Calcium carbonate (Oystercal)

 

Used in combination with vitamin D and sodium fluoride.

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Contributor Information and Disclosures
Author

Peter S Roland, MD  Professor, Department of Neurological Surgery, Professor and Chairman, Department of Otolaryngology-Head and Neck Surgery, Director of Clinical Center for Auditory, Vestibular and Facial Nerve Disorders, Chief of Pediatric Otology, University of Texas Southwestern Medical Center; Adjunct Professor of Communicative Disorders, University of Texas School of Human Development

Peter S Roland, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American Auditory Society, American Laryngological Rhinological and Otological Society, American Neurotology Society, American Otological Society, North American Skull Base Society, and Society of University Otolaryngologists-Head and Neck Surgeons

Disclosure: Alcon Labs Honoraria Speaking and teaching; GSK Honoraria Speaking and teaching; Advanced Bionics Honoraria Board membership; Cochlear Corp Honoraria Board membership; Med El Corp travel grants Consulting

Specialty Editor Board

Orval Brown, MD  Director of Otolaryngology Clinic, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center at Dallas

Orval Brown, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Academy of Pediatrics, American Bronchoesophagological Association, American College of Surgeons, American Medical Association, American Society of Pediatric Otolaryngology, Society for Ear, Nose and Throat Advances in Children, and Society of University Otolaryngologists-Head and Neck Surgeons

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

John E McClay, MD  Associate Professor of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Dallas, University of Texas Southwestern Medical School

John E McClay, MD is a member of the following medical societies: American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, and American Medical Association

Disclosure: Nothing to disclose.

Daniel Rauch, MD, FAAP  Director, Pediatric Hospitalist Program, Associate Professor, Department of Pediatrics, New York University School of Medicine

Daniel Rauch, MD, FAAP is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, and Society of Hospital Medicine

Disclosure: Baxter Honoraria Consulting

Chief Editor

Glenn C Isaacson, MD, FACS, FAAP  Professor of Otolaryngology-Head and Neck Surgery and Pediatrics, Temple University School of Medicine

Glenn C Isaacson, MD, FACS, FAAP is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Academy of Pediatrics, American Bronchoesophagological Association, American College of Surgeons, American Laryngological Rhinological and Otological Society, American Society of Pediatric Otolaryngology, and Society of University Otolaryngologists-Head and Neck Surgeons

Disclosure: Covidien Honoraria Consulting

References

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  2. Ealy M, Chen W, Ryu GY, et al. Gene expression analysis of human otosclerotic stapedial footplates. Hear Res. Jun 2008;240(1-2):80-6. [Medline].

  3. Michaels L, Soucek S. Origin and growth of otosclerosis. Acta Otolaryngol. May 2011;131(5):460-8. [Medline].

  4. Shambaugh GE Jr, Causse J. Ten years experience with fluoride in otosclerotic (otospongiotic) patients. Ann Otol Rhinol Laryngol. Sep-Oct 1974;83(5):635-42. [Medline].

  5. Shambaugh GE Jr, Petrovic A. Effects of sodium fluoride on bone. Application to otosclerosis and other decalcifying bone diseases. JAMA. Jun 10 1968;204(11):969-73. [Medline].

  6. Bittermann AJ, Rovers MM, Tange RA, Vincent R, Dreschler WA, Grolman W. Primary stapes surgery in patients with otosclerosis: prediction of postoperative outcome. Arch Otolaryngol Head Neck Surg. Aug 2011;137(8):780-4. [Medline].

  7. Denoyelle F, Daval M, Leboulanger N, Rousseau A, Roger G, Loundon N, et al. Stapedectomy in children: causes and surgical results in 35 cases. Arch Otolaryngol Head Neck Surg. Oct 2010;136(10):1005-8. [Medline].

  8. Causse JR, Causse JB, Bretlau P, et al. Etiology of otospongiotic sensorineural losses. Am J Otol. Mar 1989;10(2):99-107. [Medline].

  9. Dornhoffer JL, Bailey HA Jr, Graham SS. Long-term hearing results following stapedotomy. Am J Otol. Sep 1994;15(5):674-8. [Medline].

  10. Hannley MT. Audiologic characteristics of the patient with otosclerosis. Otolaryngol Clin North Am. Jun 1993;26(3):373-87. [Medline].

  11. Hinojosa R, Marion M. Otosclerosis and sensorineural hearing loss: a histopathologic study. Am J Otolaryngol. Sep-Oct 1987;8(5):296-307. [Medline].

  12. Hough JV, Dyer RK Jr. Stapedectomy. Causes of failure and revision surgery in otosclerosis. Otolaryngol Clin North Am. Jun 1993;26(3):453-70. [Medline].

  13. Iurato S, Ettorre GC, Onofri M, Davidson C. Very far-advanced otosclerosis. Am J Otol. Sep 1992;13(5):482-7. [Medline].

  14. Linthicum FH Jr. Histopathology of otosclerosis. Otolaryngol Clin North Am. Jun 1993;26(3):335-52. [Medline].

  15. Rama-Lopez J, Cervera-Paz FJ, Manrique M. Cochlear implantation of patients with far-advanced otosclerosis. Otol Neurotol. Feb 2006;27(2):153-8. [Medline].

  16. Rizer FM, Lippy WH. Evolution of techniques of stapedectomy from the total stapedectomy to the small fenestra stapedectomy. Otolaryngol Clin North Am. Jun 1993;26(3):443-51. [Medline].

  17. Roland PS, Meyerhof WL. Otosclerosis. In: Head and neck Surgery-Otolaryngology. Vol 2. 1998:2083-97.

  18. Willis R. Stapedectomy--past and present. Ann Acad Med Singapore. Sep 1991;20(5):680-5. [Medline].

  19. Zehnder AF, Kristiansen AG, Adams JC, et al. Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss. Laryngoscope. Feb 2006;116(2):201-6. [Medline].

 
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