Hymenolepiasis 

  • Author: Robert W Tolan Jr, MD; Chief Editor: Russell W Steele, MD   more...
 
Updated: Jan 9, 2012
 

Background

Hymenolepis nana is the cestode that most commonly infects humans, especially school-aged children. In contrast, only a few hundred human infections with the rodent tapeworm, Hymenolepis diminuta, a tapeworm for which the human is an incidental host, have been reported.

Hymenolepiasis most frequently occurs in warm, dry regions of the developing world, where exposure to human feces results in hand-to-mouth infection. Direct person-to-person spread of H nana may occur.

Next

Pathophysiology

Humans become infected with H nana when they ingest infective eggs, most commonly by direct fecal-oral exposure. The eggs pass into the ileum and hatch into oncospheres (the larval form), which penetrate the lamina propria of the villus. Within 3-4 days, the larvae mature into the preadult cysticercoid, which then enters the gut lumen to attach to the mucosae of the villus. Mature adults, measuring 35-45 mm in length and comprising 150-200 proglottids, result within about 3 weeks. Self-mating between adjacent proglottids generates hundreds of eggs, some of which penetrate intestinal villa and some of which pass into the feces. Occasionally, rodents may ingest the eggs in feces and serve as incidental hosts and reservoirs for spread of infection. Although infection usually does not produce infection, autoinfection (which is common) or intense exposure may result in a symptomatic infection caused by a heavy parasite burden.

Human infection with H diminuta results from accidental ingestion of insects (immature fleas, flour beetles, meal worms, cockroaches) that carry the parasite in their body cavities. Infective eggs are ingested by insects and hatch in their guts. After hatching, they invade into the body cavity and become cysticercoid larvae, which are infectious for humans. After the insects are consumed and digested, the larvae are released in the small intestine and mature within 25 days into 50-cm adults. When the adult tapeworm begins to pass eggs, insect hosts can become infected again. Most infections produce no symptoms.[1]

Previous
Next

Epidemiology

Frequency

United States

Infection is most common in the Southeast (1% of school children in one study) and among institutionalized children. Among more than 200,000 stool specimens submitted to the state laboratories in 1987 for ova and parasite analysis, 0.4% were positive for H nana. Because most infections do not produce symptoms, the true incidence is likely considerably higher.

International

Infection is most common in children aged 4-10 years, in dry, warm regions of the developing world. H nana infection affects millions of people, primarily children, worldwide. Estimated rates of infection in various regions range from 0.1-58%. Regions with high reported infection rates include Sicily (46%), Argentina (34% of school children), and southern areas of the former Soviet Union (26%). In contrast, only 0.1% of stools examined at a children's hospital in Calgary were positive for H nana. Most cases with associated neurologic symptoms have been reported from the former Soviet Union.

Mortality/Morbidity

Morbidity is uncommon, only occurring when parasite burden is very high. Death has not been reported in association with this infection.

Race

No racial predisposition is known for hymenolepiasis.

Sex

No gender predilection is known for hymenolepiasis.

Age

Infection can occur in persons of any age; however, because of the increased likelihood of exposure to human feces, school-aged children have the highest risk of hymenolepiasis. Infection in adolescents tends to clear spontaneously, and hymenolepiasis is uncommon among adults.

Previous
Proceed to Clinical Presentation
 
 
Contributor Information and Disclosures
Author

Robert W Tolan Jr, MD  Chief, Division of Allergy, Immunology and Infectious Diseases, The Children's Hospital at Saint Peter's University Hospital; Clinical Associate Professor of Pediatrics, Drexel University College of Medicine

Robert W Tolan Jr, MD is a member of the following medical societies: American Academy of Pediatrics, American Medical Association, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Phi Beta Kappa, and Physicians for Social Responsibility

Disclosure: Novartis Honoraria Speaking and teaching

Specialty Editor Board

Glenn Fennelly, MD, MPH  Director, Division of Infectious Diseases, Lewis M Fraad Department of Pediatrics, Jacobi Medical Center; Clinical Associate Professor of Pediatrics, Albert Einstein College of Medicine

Glenn Fennelly, MD, MPH is a member of the following medical societies: Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Martin Weisse, MD  Program Director, Associate Professor, Department of Pediatrics, West Virginia University

Martin Weisse, MD is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Daniel Rauch, MD, FAAP  Director, Pediatric Hospitalist Program, Associate Professor, Department of Pediatrics, New York University School of Medicine

Daniel Rauch, MD, FAAP is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, and Society of Hospital Medicine

Disclosure: Baxter Honoraria Consulting

Chief Editor

Russell W Steele, MD  Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association

Disclosure: Nothing to disclose.

References

  1. Craig P, Ito A. Intestinal cestodes. Curr Opin Infect Dis. Oct 2007;20(5):524-32. [Medline].

  2. Staat MA, Rice M, Donauer S, Mukkada S, Holloway M, Cassedy A, et al. Intestinal Parasite Screening in Internationally Adopted Children: Importance of Multiple Stool Specimens. Pediatrics. Aug 8 2011;[Medline].

  3. Chero JC, Saito M, Bustos JA, Blanco EM, Gonzalvez G, Garcia HH. Hymenolepis nana infection: symptoms and response to nitazoxanide in field conditions. Trans R Soc Trop Med Hyg. Feb 2007;101(2):203-5. [Medline].

  4. Diaz E, Mondragon J, Ramirez E, Bernal R. Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico. Am J Trop Med Hyg. Apr 2003;68(4):384-5. [Medline]. [Full Text].

  5. Fox LM, Saravolatz LD. Nitazoxanide: a new thiazolide antiparasitic agent. Clin Infect Dis. Apr 15 2005;40(8):1173-80. [Medline].

  6. Gilles HM, Hoffman PS. Treatment of intestinal parasitic infections: a review of nitazoxanide. Trends Parasitol. Mar 2002;18(3):95-7. [Medline].

  7. Pearson RD. Nitazoxanide As Treatment of Intestinal Parasites in Children. Curr Infect Dis Rep. Feb 2004;6(1):25-26. [Medline].

  8. AAP. Other tapeworm infections (including hydatid disease). In: Red Book: 2009 Report of the Committee on Infectious Diseases. 28th. Elk Grove Village, IL: American Academy of Pediatrics; 2009:654-5.

  9. Alyousefi NA, Mahdy MA, Mahmud R, Lim YA. Factors associated with high prevalence of intestinal protozoan infections among patients in Sana'a City, Yemen. PLoS One. 2011;6(7):e22044. [Medline]. [Full Text].

  10. Church C, Neill A, Schotthoefer A. Seasonality of Parasitic Gut Infections in Humans in the Rocky Mountain Region, USA. J Parasitol. Oct 6 2009;1. [Medline].

  11. Cook DM, Swanson RC, Eggett DL, Booth GM. A retrospective analysis of prevalence of gastrointestinal parasites among school children in the Palajunoj Valley of Guatemala. J Health Popul Nutr. Feb 2009;27(1):31-40. [Medline].

  12. Gonçalves AL, Belizário TL, Pimentel Jde B, Penatti MP, Pedroso Rdos S. Prevalence of intestinal parasites in preschool children in the region of Uberlândia, State of Minas Gerais, Brazil. Rev Soc Bras Med Trop. Mar-Apr 2011;44(2):191-3. [Medline].

  13. Heukelbach J, Winter B, Wilcke T, et al. Selective mass treatment with ivermectin to control intestinal helminthiases and parasitic skin diseases in a severely affected population. Bull World Health Organ. Aug 2004;82(8):563-71. [Medline].

  14. Juckett G. Common intestinal helminths. Am Fam Physician. Nov 15 1995;52(7):2039-48, 2051-2. [Medline].

  15. Kabani A, Cadrain G, Trevenen C, et al. Practice guidelines for ordering stool ova and parasite testing in a pediatric population. The Alberta Children's Hospital. Am J Clin Pathol. Sep 1995;104(3):272-8. [Medline].

  16. Katz M, Despommier DD, Gwadz RW. Tapeworms of minor medical importance. Parasit Dis. 1989;88-92.

  17. Maggi P, Brandonisio O, Carito V, et al. Hymenolepis nana parasites in adopted children. Clin Infect Dis. Aug 15 2005;41(4):571-2. [Medline].

  18. Marangi M, Zechini B, Fileti A, et al. Hymenolepis diminuta infection in a child living in the urban area of Rome, Italy. J Clin Microbiol. Aug 2003;41(8):3994-5. [Medline].

  19. Marseglia GL, Marseglia A, Licari A, Castellazzi AM, Ciprandi G. Chronic urticaria caused by Hymenolepis nana in an adopted girl. Allergy. Jul 2007;62(7):821-2. [Medline].

  20. Mehraj V, Hatcher J, Akhtar S, Rafique G, Beg MA. Prevalence and factors associated with intestinal parasitic infection among children in an urban slum of Karachi. PLoS ONE. 2008;3(11):e3680. [Medline].

  21. Olson PD, Yoder K, Fajardo L-G LF, et al. Lethal invasive cestodiasis in immunosuppressed patients. J Infect Dis. Jun 15 2003;187(12):1962-6. [Medline].

  22. Patamia I, Cappello E, Castellano-Chiodo D, Greco F, Nigro L, Cacopardo B. A human case of Hymenolepis diminuta in a child from eastern Sicily. Korean J Parasitol. Jun 2010;48(2):167-9. [Medline]. [Full Text].

  23. Quihui L, Valencia ME, Crompton DW, et al. Role of the employment status and education of mothers in the prevalence of intestinal parasitic infections in Mexican rural schoolchildren. BMC Public Health. 2006;6:225. [Medline].

  24. Quihui-Cota L, Valencia ME, Crompton DW, et al. Prevalence and intensity of intestinal parasitic infections in relation to nutritional status in Mexican schoolchildren. Trans R Soc Trop Med Hyg. Nov 2004;98(11):653-9. [Medline].

  25. Rayan P, Verghese S, McDonnell PA. Geographical location and age affects the incidence of parasitic infestations in school children. Indian J Pathol Microbiol. Jul-Sep 2010;53(3):498-502. [Medline].

  26. Richards FO Jr. Diphyllobothrium, Dipylidium, and Hymenolepis species. In: Principles and Practice of Pediatric Infectious Diseases. 2003:1351-4.

  27. Robertson J, Shilkofski N. Drug doses. In: The Harriet Lane Handbook: A Manual for Pediatric House Officers. Philadelphia, Pa: Mosby; 2005:679-1009.

  28. Rokni MB. The present status of human helminthic diseases in Iran. Ann Trop Med Parasitol. Jun 2008;102(4):283-95. [Medline].

  29. Schantz PM. Tapeworms (cestodiasis). Gastroenterol Clin North Am. Sep 1996;25(3):637-53. [Medline].

  30. Tanowitz HB, Wittner M. Hymenolepiasis. In: Hunter's Tropical Medicine. 1991:839-41.

  31. Turner JA. Cestodes. In: Textbook of Pediatric Infectious Diseases. 2004:2797-816.

  32. Utzinger J, Botero-Kleiven S, Castelli F, Chiodini PL, Edwards H, Köhler N, et al. Microscopic diagnosis of sodium acetate-acetic acid-formalin-fixed stool samples for helminths and intestinal protozoa: a comparison among European reference laboratories. Clin Microbiol Infect. May 18 2009;[Medline].

  33. Weisse ME, Raszka WV Jr. Cestode infection in children. Adv Pediatr Infect Dis. 1996;12:109-53. [Medline].

  34. Wittner M, Tanowitz HB. Other cestode infections. In: Tropical Infectious Diseases: Principles, Pathogens, and Practice. 1999:1026-30.

 
Previous
Next
 
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.