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Daytrana - ADHD Treatment That Sticks

FOR YOUR PATIENTS

Taking Care of the Skin They're In: Expert Advice About Daytrana and Children's Skin
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Dr. Sharon Jacob

Dr. Sharon Jacob

Director, Contact Dermatitis Clinic of the University of Miami-Miller School of Medicine and Assistant Professor, Clinical Dermatology, Department of Dermatology and Cutaneous Surgery; President, Florida Contact Dermatitis Society and a consultant for Shire US Inc.

Full Prescribing Information

Important Safety Information

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Advanced MPH Delivery Using DOT Matrix™ Patch Technology

Daytrana provides advanced MPH delivery that may be beneficial to your patients. The individualized duration of effect focuses on the changing daily needs of your patients and their families.

Advanced MPH Delivery

Third-generation DOT Matrix patch technology combines MPH and adhesive in a single layer for excellent adhesion and delivery of medication^1,3

Daytrana Is Designed With Patients in Mind

Daytrana offers an individualized approach to treatment of ADHD. The methylphenidate patch is clear, thin and designed to be easy to apply¹⁴ and is a single-layer design to provide day-long adhesion
The patch formulation offers individualized duration of effect. It can be worn up to 9 hours – but can be removed earlier to accommodate the changing daily needs of your patients and their families.¹ In addition, it provides the caregiver visual confirmation of patch use
Upon removal, the patch should be folded in half, with sticky sides together, and discarded immediately in the toilet or lidded container¹

DOT Matrix™ is a trademark of Noven Pharmaceuticals, Inc.

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More About How the Patch Works

Important Safety Information

Daytrana should not be used in patients with allergy to methylphenidate or patch components; marked anxiety, tension and agitation; glaucoma; tics, diagnosis or a family history of Tourette's syndrome; seizures; or during or within 14 days after treatment with monoamine oxidase inhibitors (MAOIs).

Sudden death has been reported in association with CNS stimulant treatment at usual doses in children and adolescents with structural cardiac abnormalities or other serious heart problems. Sudden deaths, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses in ADHD. Physicians should take a careful patient history, including family history, and physical exam to assess the presence of cardiac disease. Patients who report symptoms of cardiac disease such as exertional chest pain and unexplained syncope should be promptly evaluated. Use with caution in patients whose underlying medical condition might be affected by increases in blood pressure or heart rate.

New psychosis, mania, aggression, growth suppression, and visual disturbances have been associated with the use of stimulants. Use with caution in patients with a history of: psychosis; EEG abnormalities; bipolar disorder; depression. Growth and hematologic monitoring is advised during prolonged treatment. Patients should avoid applying external heat to the Daytrana patch. Erythema has been commonly reported. Contact sensitization may occur.

Daytrana should be given cautiously to patients with a history of drug dependence and alcoholism. Chronic abuse can lead to marked tolerance and psychological dependence. Frank psychotic episodes can occur, especially with parenteral abuse. Careful supervision is required during withdrawal from abusive use, since severe depression may occur. Withdrawal following chronic therapeutic use may unmask symptoms of the underlying disorder.

Common adverse events reported by patients who received Daytrana in clinical trials were decreased appetite, insomnia, nausea, vomiting, decreased weight, tics, affect lability, and anorexia, consistent with adverse events commonly associated with the use of methylphenidate.

^†McGough JJ, Wigal SB, Abikoff H, et al. A randomized, double-blind, placebo-controlled laboratory classroom assessment of methylphenidate transdermal system in children with ADHD. J Atten Disord. 2006;9:476-485.

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