Pediatric Anti-GBM Disease (Goodpasture Syndrome) Differential Diagnoses

Updated: Dec 16, 2020
  • Author: Rudolph P Valentini, MD; Chief Editor: Girish D Sharma, MD, FCCP, FAAP  more...
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Diagnostic Considerations

It is essential to promptly diagnose pulmonary hemorrhage, because this is the principal cause of early death in patients with in anti–glomerular basement membrane (anti-GBM) disease (Goodpasture disease).

When renal disease is present, it can then be isolated or accompanied by pulmonary hemorrhage. When significant renal disease is present, it usually progresses rapidly.

Essential mixed cryoglobulinemia should also be considered when evaluating a patient with suspected anti-GBM disease.

Differential Diagnoses