Behcet Syndrome Questions & Answers

1. Ozen S, Eroglu FK. Pediatric-onset Behçet disease. Curr Opin Rheumatol. 2013 Sep. 25(5):636-42. [Medline].

2. Talaat RM, Ashour ME, Bassyouni IH, Raouf AA. Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Behcet's disease. Immunobiology. 2014 Mar 20. [Medline].

3. Al-Araji A, Kidd DP. Neuro-Behcet's disease: epidemiology, clinical characteristics, and management. Lancet Neurol. 2009 Feb. 8(2):192-204. [Medline].

4. Leccese P, Yazici Y, Olivieri I. Behcet's syndrome in nonendemic regions. Curr Opin Rheumatol. 2017 Jan. 29 (1):12-16. [Medline].

5. Uluduz D, Kürtüncü M, Yapici Z, Seyahi E, Kasapçopur Ö, Özdogan H, et al. Clinical characteristics of pediatric-onset neuro-Behçet disease. Neurology. 2011 Nov 22. 77(21):1900-5. [Medline].

6. Ebert EC. Gastrointestinal manifestations of Behçet's disease. Dig Dis Sci. 2009 Feb. 54(2):201-7. [Medline].

7. Al-Dhibi H, Abouammoh M, Al-Harthi E, Al-Gaeed A, Larsson J, Abboud E, et al. Macular hole in Behçet's disease. Indian J Ophthalmol. 2011 Sep-Oct. 59(5):359-62. [Medline]. [Full Text].

8. Al-Mujaini A, Wali UK. Frosted branch angiitis, neuroretinitis as initial ocular manifestation in Behçet disease. Indian J Ophthalmol. 2011 May-Jun. 59(3):240-1. [Medline]. [Full Text].

9. Louali FE, Tamdy A, Soufiani A, Oukerraj L, Omari D, Bounjoum F, et al. Cardiac thrombosis as a manifestation of Behçet syndrome. Tex Heart Inst J. 2010. 37(5):568-71. [Medline]. [Full Text].

10. Seyahi E, Yurdakul S. Behçet's Syndrome and Thrombosis. Mediterr J Hematol Infect Dis. 2011. 3(1):e2011026. [Medline]. [Full Text].

11. Ilhan B, Can M, Alibaz-Oner F, Yilmaz-Oner S, Polat-Korkmaz O, Ozen G, et al. Fatigue in patients with Behcet's syndrome: relationship with quality of life, depression, anxiety, disability and disease activity. Int J Rheum Dis. 2016 Feb 23. [Medline].

12. Buyuktas D, Hatemi G, Yuksel-Findikoglu S, Ugurlu S, Yazici H, Yurdakul S. Fatigue is correlated with disease activity but not with the type of organ involvement in Behçet's syndrome: a comparative clinical survey. Clin Exp Rheumatol. 2015 Nov-Dec. 33 (6 Suppl 94):S107-12. [Medline].

13. Ihle J, Kummerle-Deschner J, Orlikowsky T, Albert E, Niethammer D, Dannecker GE. Factor V Leiden and venous thrombosis in a 4-yr-old girl with Behcet's syndrome. Rheumatology (Oxford). 2000 Feb. 39(2):209-10. [Medline].

14. [Guideline] Hatemi G, Silman A, Bang D, Bodaghi B, Chamberlain AM, Gul A. EULAR recommendations for the management of Behçet disease. Ann Rheum Dis. 2008 Dec. 67(12):1656-62. [Medline].

15. Alpsoy E. Behcet's disease: treatment of mucocutaneous lesions. Clin Exp Rheumatol. 2005 Jul-Aug. 23(4):532-9. [Medline].

16. Fresko I, Soy M, Hamuryudan V, et al. Genetic anticipation in Behcet's syndrome. Ann Rheum Dis. 1998 Jan. 57(1):45-8. [Medline].

17. Gerber S, Biondi A, Dormont D, Wechsler B, Marsault C. Long-term MR follow-up of cerebral lesions in neuro-Behcet's disease. Neuroradiology. 1996 Nov. 38(8):761-8. [Medline].

18. Kesen MR, Goldstein DA, Tessler HH. Uveitis associated with pediatric Behcet disease in the american midwest. Am J Ophthalmol. 2008 Dec. 146(6):819-27.e2. [Medline].

19. Kikuchi H, Aramaki K, Hirohata S. Effect of infliximab in progressive neuro-Behcet's syndrome. J Neurol Sci. 2008 Sep 15. 272(1-2):99-105. [Medline].

20. Kone-Paut I, Geisler I, Wechsler B, et al. Familial aggregation in Behcet's disease: high frequency in siblings and parents of pediatric probands. J Pediatr. 1999 Jul. 135(1):89-93. [Medline].

21. Marshall SE. Behcet's disease. Best Pract Res Clin Rheumatol. 2004 Jun. 18(3):291-311. [Medline].

22. Martini A. Behcet's disease and Takayasu's disease in children. Curr Opin Rheumatol. 1995 Sep. 7(5):449-54. [Medline].

23. Melikoglu M, Fresko I, Mat C, et al. Short-term trial of etanercept in Behçet's disease: a double blind, placebo controlled study. J Rheumatol. 2005 Jan. 32(1):98-105. [Medline].

24. Nakamura S, Ohno S. Anti-tumor necrosis factor alpha antibody in the treatment of Behcet's disease. Int Ophthalmol Clin. 2005. 45(2):179-89. [Medline].

25. Oktem-Tanor O, Baykan-Kurt B, Gurvit IH, et al. Neuropsychological follow-up of 12 patients with neuro-Behcet disease. J Neurol. 1999 Feb. 246(2):113-9. [Medline].

26. Rakavor Y, Adar H, Tal I, et al. Behcet Disease: Long-term follow-up of three children and review of the literature. Pediatrics. 1989. 83:986-92. [Medline].

27. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet's disease. N Engl J Med. 1999 Oct 21. 341(17):1284-91. [Medline].

28. Tabbara KF, Al-Hemidan AI. Infliximab effects compared to conventional therapy in the management of retinal vasculitis in Behçet disease. Am J Ophthalmol. 2008 Dec. 146(6):845-50.e1. [Medline].

29. Yazici H, Pazarli H, Barnes CG, et al. A controlled trial of azathioprine in Behcet's syndrome. N Engl J Med. 1990 Feb 1. 322(5):281-5. [Medline].

C Egla Rabinovich, MD, MPH Associate Professor and Co-Division Chief, Department of Pediatrics, Division of Pediatric Rheumatology, Duke University Medical Center

C Egla Rabinovich, MD, MPH is a member of the following medical societies: American College of Rheumatology

Disclosure: Received grant/research funds from Abbott for clincal trial; Received grant/research funds from UCB for clinical trial; Received grant/research funds from Janssen for clinical trial; Received grant/research funds from Hoffmann-La Roche Inc. for clinical trial.

Linda Wagner-Weiner, MD Associate Professor, Department of Pediatrics, University of Chicago, The Pritzker School of Medicine

Linda Wagner-Weiner, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Rheumatology

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Thomas JA Lehman, MD FAAP, FACR, Clinical Professor of Pediatrics, Department of Pediatrics, Division of Pediatric Rheumatology, Weill Cornell Medical College; Chief, Hospital for Special Surgery

Thomas JA Lehman, MD is a member of the following medical societies: PM American Allergy Society

Disclosure: Nothing to disclose.

Lawrence K Jung, MD Chief, Division of Pediatric Rheumatology, Children's National Medical Center

Lawrence K Jung, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Immunologists, American College of Rheumatology, Clinical Immunology Society, New York Academy of Sciences

Disclosure: Nothing to disclose.

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