Neonatal and Pediatric Lupus Erythematosus Differential Diagnoses

Updated: May 17, 2021
  • Author: Alisa N Femia, MD; Chief Editor: Lawrence K Jung, MD  more...
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Diagnostic Considerations

At birth, the 4 main considerations in the differential diagnosis of neonatal lupus erythematosus (NLE) are usually congenital rubella, congenital syphilis, Bloom syndrome, and Rothmund-Thomson syndrome. Cockayne syndrome may also manifest with photodistributed erythema on the face and therefore should be considered in the differential diagnosis. Later, slightly atrophic vascular patches may resemble other disorders, including lymphangiomas.

The following conditions should also be considered when evaluating a patient with suspected neonatal lupus erythematosus:

  • Atrioventricular block

  • Drug eruptions

  • Juvenile dermatomyositis

  • Juvenile sarcoidosis

  • Malignancy

  • Milia

  • Primary immunodeficiencies

  • Toxic exposures

  • Viral or bacterial infections

Differential Diagnoses