Transient Synovitis Medication

Updated: Dec 20, 2018
  • Author: Christine C Whitelaw, MD; Chief Editor: Lawrence K Jung, MD  more...
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Medication

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Class Summary

These agents have analgesic, antiinflammatory, and antipyretic activities. They act by inhibiting cyclooxygenase activity, which results in decreased prostaglandin synthesis. Other mechanisms, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell-membrane functions, may also exist.

Naproxen and ibuprofen are the most frequently prescribed NSAIDs in children, with a suspension form and safety and efficacy studies available. The COX-2 inhibitors have not yet been studied adequately in the pediatric population.

Naproxen (Aleve, Naprosyn, Anaprox)

NSAID that inhibits cyclooxygenase, thus inhibiting formation of prostaglandins.

Ibuprofen (Motrin, Advil)

NSAID that inhibits cyclooxygenase, thus inhibiting formation of prostaglandins.