Rhabdomyolysis Differential Diagnoses

Updated: Nov 10, 2017
  • Author: Eyal Muscal, MD, MS; Chief Editor: Lawrence K Jung, MD  more...
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Diagnostic Considerations

A preliminary diagnosis of rhabdomyolysis requires a high index of suspicion. A definitive diagnosis is achieved by means of laboratory evaluation (see Workup).

In addition to the conditions listed in the differential diagnosis, other problems to be considered include the following:

  • Traumatic injuries (including nonaccidental abuse in children)
  • Viral infections
  • Myalgias from other etiologies
  • Bacterial infections
  • Cold exposure
  • Malignant hyperthermia
  • Muscle phosphorylase deficiency
  • Phosphofructokinase deficiency
  • Carnitine palmityl transferase deficiency
  • Phosphoglycerate mutase deficiency
  • Hyperosmotic conditions
  • Guillain-Barré syndrome
  • Inflammatory myositis