Pediatric Systemic Lupus Erythematosus Differential Diagnoses

Updated: Nov 02, 2015
  • Author: Marisa S Klein-Gitelman, MD, MPH; Chief Editor: Lawrence K Jung, MD  more...
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DDx

Diagnostic Considerations

As previously mentioned, the ACR classification criteria require 4 of 11 specific findings, which have 96-99% specificity (see History). Differential diagnoses should include the following:

  • Infection
  • Malignancy
  • Toxic exposures
  • Other multisystem diseases

Specific conditions to consider in the differential diagnosis of systemic lupus erythematosus (SLE) include the following:

  • Acute anemia
  • Acute poststreptococcal glomerulonephritis
  • Chronic anemia
  • Angioedema
  • Anti-GBM antibody disease
  • Antiphospholipid antibody syndrome
  • Obsessive-compulsive disorder
  • Specific phobia
  • Trichotillomania
  • Appendicitis
  • Arthritis, conjunctivitis, urethritis syndrome
  • Septic arthritis
  • Autoimmune and chronic benign neutropenia
  • Autoimmune chronic active hepatitis
  • Dilated cardiomyopathy
  • Chronic granulomatous disease
  • Anorexia
  • Bacterial endocarditis
  • Bacterial pericarditis
  • Complement deficiency
  • Complement receptor deficiency
  • Evans syndrome
  • Fever without a focus
  • Fibromyalgia
  • Fulminant hepatic failure
  • Goodpasture syndrome
  • Graves disease
  • Congestive heart failure
  • Hematuria
  • Hemolytic-uremic syndrome
  • Henoch-Schönlein purpura
  • Mitral valve insufficiency
  • Mitral valve prolapse
  • Mixed connective tissue disease
  • Bipolar disorder
  • Depression
  • Dysthymic disorder
  • Hepatitis B
  • Hodgkin disease
  • Hyperthyroidism
  • Hypothyroidism
  • Kawasaki disease
  • Lymphadenopathy
  • Nephritis
  • Nephrotic syndrome
  • Nonviral myocarditis
  • Oliguria
  • Parvovirus B19 infection
  • Pleural effusion
  • Polyarteritis nodosa
  • Proteinuria
  • Rheumatic fever
  • Rheumatic heart disease
  • Serum sickness
  • Sjögren syndrome
  • Systemic sclerosis
  • Thyroid storm
  • Generalized anxiety
  • Behçet syndrome
  • Thyroiditis
  • Urticaria

Differential Diagnoses